Central Auditory Processing in Alzheimerʼs Disease

Strouse, Anne; Hall, James W.; Burger, Marlette

doi:10.1097/00003446-199504000-00010

Cited by 89 publications

(88 citation statements)

References 29 publications

(47 reference statements)

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“…This contrasts with previous work characterising a generic impairment of auditory scene analysis in AD [33,35,36,[72][73][74][75] and may in part reflect the relatively wide variation in healthy control performance on our tune streaming test (Figure 3). However, it is possible that the analysis of musical scenes benefits to a greater degree than other kinds of auditory scenes from the availability of stored templates, here familiar tunes.…”

Section: Europe Pmc Funders Author Manuscriptscontrasting

confidence: 99%

“…Available evidence suggests that the decoding of musical patterns may be affected by common dementias and may help to stratify dementia syndromes and pathologies without relying on more specialised (and potentially confounding) verbal mechanisms. Elementary pitch discrimination may be retained in AD and impaired in PNFA, consistent with relatively greater involvement of early auditory areas in neurodegenerative processes that target periSylvian cortex [18,[32][33][34][35][36]. However, the effects of these diseases on more complex pitch pattern processing have not been resolved.…”

Section: Introductionmentioning

confidence: 99%

“…In the healthy brain perceptual analysis of rhythm and metre engages cortico-subcortical circuitry jointly involved in preparing motor output [58][59][60][61]. While evidence in AD is not conclusive [19,36,62,63], impairments of temporal pattern processing have been described in PNFA associated with involvement of peri-Sylvian cortex [64]: this may be attributable both to loss of dynamic precision mediated by the dominant hemisphere and the high temporal resolution required for accurate processing of speech signals [65,66].…”

Section: Introductionmentioning

confidence: 99%

“…Musical scene analysis has not been widely studied neuropsychologically in clinical populations but is likely to engage posterior superior temporal and parietal lobe regions and their dorsal projections [68][69][70][71][72]. AD has been shown to produce a generic impairment of auditory scene analysis under diverse listening tasks and conditions, including the streaming of sound sequences that bear some similarities to musical melodies; this has been linked to dysfunction of posterior temporoparietal areas overlapping those involved in music perception [33,35,36,[73][74][75]. On both neuroanatomical and neuropsychological grounds, patients with AD might therefore be anticipated to have difficulties with musical scene analysis; however, this has not been addressed directly in previous work.…”

Section: Introductionmentioning

confidence: 99%

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Music Perception in Dementia

Golden

Clark

Nicholas

et al. 2016

JAD

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# These authors contributed equally to this work. AbstractDespite much recent interest in music and dementia, music perception has not been widely studied across dementia syndromes using an information processing approach. Here we addressed this issue in a cohort of 30 patients representing major dementia syndromes of typical Alzheimer's disease (AD, n=16), logopenic aphasia (LPA, an Alzheimer variant syndrome; n=5) and progressive nonfluent aphasia (PNFA; n=9) in relation to 19 healthy age-matched individuals. We designed a novel neuropsychological battery to assess perception of musical patterns in the dimensions of pitch and temporal information (requiring detection of notes that deviated from the established pattern based on local or global sequence features) and musical scene analysis (requiring detection of a familiar tune within polyphonic harmony). Performance on these tests was referenced to generic auditory (timbral) deviance detection and recognition of familiar tunes and adjusted for general auditory working memory performance. Relative to healthy controls, patients with AD and LPA had group-level deficits of global pitch (melody contour) processing while patients with PNFA as a group had deficits of local (interval) as well as global pitch processing. There was substantial individual variation within syndromic groups. No specific deficits of musical temporal processing, timbre processing, musical scene analysis or tune recognition were identified. The findings suggest that particular aspects of music perception such as pitch pattern analysis may open a window on the processing of information streams in major dementia syndromes. The potential selectivity of musical deficits for particular dementia syndromes and particular dimensions of processing warrants further systematic investigation.

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Section: Europe Pmc Funders Author Manuscriptscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Music Perception in Dementia

Golden

Clark

Nicholas

et al. 2016

JAD

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“…A disfunção auditiva central já foi caracterizada, por meio de respostas de tronco cerebral, em pacientes diagnosticados com demência, que inclusive não apresentavam maiores taxas de déficit auditivo periférico se comparados com controles (Sinha et al, 1993 (Strouse et al, 1995).…”

Section: Perfil Audiológico No Idosounclassified

Treinamento auditivo em idosos com comprometimento cognitivo leve

Souza¹

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Central Auditory Dysfunction as a Harbinger of Alzheimer Dementia

Gates

Anderson²,

McCurry³

et al. 2011

Arch Otolaryngol Head Neck Surg

214

221

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Objective Confirm that central auditory dysfunction may be a precursor to the onset of Alzheimer’s Disease (AD) Design Cohort study Setting Research study center Participants 274 volunteers from a dementia surveillance cohort were followed for up to 4 years after having complete audiometric assessment. 21 of the participants received a consensus diagnosis of AD after hearing testing. Intervention Three central auditory tests were performed: the Dichotic Sentence Identification, the Dichotic Digits, and the Synthetic Sentence Identification with Ipsilateral Competing Message. Main Outcome Measures A new diagnosis of Alzheimer’s disease using the National Institute of Neurological and Communicative Diseases and Stroke–Alzheimer’s Disease and Related Disorders Association criteria at a consensus conference Results The mean scores on each CAD test were significantly poorer in the incident dementia group. Cox proportional hazards models with age as the time-scale were used to estimate the hazard ratio for incident dementia based on CAD test results. After adjusting for educational level, the hazard ratio for incident dementia in people with severe CAD based on a Dichotic Sentence Identification in free report mode of <50% was 9.9 (95% C.I. 3.6, 26.7). Conclusions In these cases, CAD was a precursor to Alzheimer’s dementia. We recommend evaluating older adults complaining of hearing difficulty with CAD tests. Those with severe CAD should receive a modified rehabilitation program and be considered for referral for neurologic evaluation.

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Central Auditory Processing in Alzheimerʼs Disease

Cited by 89 publications

References 29 publications

Music Perception in Dementia

Music Perception in Dementia

Treinamento auditivo em idosos com comprometimento cognitivo leve

Central Auditory Dysfunction as a Harbinger of Alzheimer Dementia

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