Central Auditory Dysfunction May Precede the Onset of Clinical Dementia in People with Probable Alzheimer's Disease

Gates, George A.; Beiser, Alexa; Rees, Thomas S.; D’Agostino, Ralph B.; Wolf, Philip A.

doi:10.1046/j.1532-5415.2002.50114.x

Cited by 181 publications

(169 citation statements)

References 32 publications

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“…However, more global measures of cognitive skills, not necessarily measuring working memory capacity, showed no significant improvement after 12 months of hearing aid use (van Hooren et al, 2005), although it is possible that performance may have declined if hearing aids had not been worn. Consistent with this is the finding that auditory speech processing problems were predictive of future manifestation of dementia in longitudinal research conducted over periods of up to 12 years (Gates, Beiser, Rees, D'Agostino, & Wolf, 2002;Gates, Feeney, & Mills, 2008). That hearing rehabilitative interventions could alter the time course of the onset of dementia symptoms is of significant clinical importance.…”

Section: Rehabilitationmentioning

confidence: 55%

Normal Adult Aging and the Contextual Influences Affecting Speech and Meaningful Sound Perception

Aydelott

Leech

Crinion

2010

Trends in Amplification

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It is widely accepted that hearing loss increases markedly with age, beginning in the fourth decade ISO 7029 (2000). Age-related hearing loss is typified by high-frequency threshold elevation and associated reductions in speech perception because speech sounds, especially consonants, become inaudible. Nevertheless, older adults often report additional and progressive difficulties in the perception and comprehension of speech, often highlighted in adverse listening conditions that exceed those reported by younger adults with a similar degree of high-frequency hearing loss (Dubno, Dirks, & Morgan) leading to communication difficulties and social isolation (Weinstein & Ventry). Some of the age-related decline in speech perception can be accounted for by peripheral sensory problems but cognitive aging can also be a contributing factor. In this article, we review findings from the psycholinguistic literature predominantly over the last four years and present a pilot study illustrating how normal agerelated changes in cognition and the linguistic context can influence speech-processing difficulties in older adults. For significant progress in understanding and improving the auditory performance of aging listeners to be made, we discuss how future research will have to be much more specific not only about which interactions between auditory and cognitive abilities are critical but also how they are modulated in the brain.

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Section: Rehabilitationmentioning

confidence: 55%

Normal Adult Aging and the Contextual Influences Affecting Speech and Meaningful Sound Perception

Aydelott

Leech

Crinion

2010

Trends in Amplification

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“…Other authors have previously reported a significant association between MCI and CAPD in smaller numbers of subjects [Idrizbegovic et al, 2011;Rahman et al, 2011]. Gates et al [2008] demonstrated that central auditory tests are frequently abnormal in memory-impaired, nondemented older individuals, as well as in subjects with 'probable Alzheimer's disease' [Gates et al, 2002]. Given that about half of older adults with isolated memory loss progress to dementia [Bowen et al, 1997] and 80% of patients affected by amnestic MCI convert to AD ultimately [Petersen et al, 2001], inclusion of auditory tests to the routine screening cognitive test battery may have value in the early diagnosis of cognitive decline.…”

Section: Discussionmentioning

confidence: 95%

The Prevalence of Peripheral and Central Hearing Impairment and Its Relation to Cognition in Older Adults

Quaranta¹,

Coppola²,

Casulli³

et al. 2014

Audiol Neurotol

111

123

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Age-related hearing loss (ARHL) and dementia are two highly prevalent conditions in the adult population. Recent studies have suggested that hearing loss is independently associated with poorer cognitive functioning. The aim of this study was to evaluate the prevalence of ARHL and cognitive impairment in a large sample of subjects older than 65 years and to correlate hearing function with cognitive function. A total of 488 subjects older than 65 years (mean age 72.8 years) participating in the Great Age Study underwent a complete audiological, neurological and neuropsychological evaluation as part of a multidisciplinary assessment. The prevalence of a hearing loss greater than 25 dB HL was 64.1%, of Central Auditory Processing Disorder (CAPD) was 14.3 and 25.3% of the subjects reported a hearing handicap as reported on the Hearing Handicap Inventory for the Elderly Screening Version questionnaire. Multiple logistic regression analysis corrected for gender, age and education duration showed that mild cognitive impairment (MCI) was significantly associated with hearing impairment (CAPD and hearing threshold; odds ratio 1.6, p = 0.05) and that Alzheimer's disease (AD) was significantly associated with CAPD (odds ratio 4.2, p = 0.05). Given that up to 80% of patients affected by MCI convert to AD, adding auditory tests to a screening cognitive battery might have value in the early diagnosis of cognitive decline.

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“…With further progression of AD, impaired comprehension of speech and writing with relatively preserved verbal repetition and reading aloud is often seen. This suggests a clinical picture similar to that of transcortical sensory aphasia (Gates et al, 2002;Mendez and Cummings, 2003). Progressive deterioration involves semantic aspects, grammatical complexity, and prepositional content but basic syntactic and phonologic aspects of language seem to be less vulnerable in AD (Backman and Small, 1998;Harasty et al, 2001;Kemper et al, 2001).…”

Section: Language Abnormalitiesmentioning

confidence: 77%

Neuropsychological Differences Between Frontotemporal Dementia and Alzheimer's Disease: A Review

Harciarek

Jodzio

2005

Neuropsychol Rev

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This paper surveys the similarities and differences between frontotemporal dementia (FTD) and Alzheimer's disease (AD). The review covers findings primarily from neuropsychological studies on memory, language, attention/executive function, and visuospatial abilities. However, neuropsychiatric and neuroimaging data are also briefly discussed. Distinguishing features of both FTD and AD are described in order to present a comprehensive clinical picture of these dementing diseases, which is essential for the process of differential diagnosis. The cause of specific cognitive deficits is also considered. Our comprehensive review of the empirical literature reveals that AD is characterized by early memory loss and visuospatial problems, while among the main features of FTD are behavioral abnormalities and executive dysfunctions.

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Central Auditory Dysfunction May Precede the Onset of Clinical Dementia in People with Probable Alzheimer's Disease

Abstract: Central auditory speech-processing deficits may be an early manifestation of probable Alzheimer's disease and may precede the onset of dementia diagnosis by many years.

Cited by 181 publications

References 32 publications

Normal Adult Aging and the Contextual Influences Affecting Speech and Meaningful Sound Perception

Normal Adult Aging and the Contextual Influences Affecting Speech and Meaningful Sound Perception

The Prevalence of Peripheral and Central Hearing Impairment and Its Relation to Cognition in Older Adults

Neuropsychological Differences Between Frontotemporal Dementia and Alzheimer's Disease: A Review

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