Central and peripheral actions of amphetamine on memory storage

Martinez, Joe L.; Jensen, Robert A.; Messing, Rita B.; Vasquez, Beatriz J.; Soumireu-Mourat, Bernard; Geddes, D. M.; Liang, Keng Chen; McGaugh, James L.

doi:10.1016/0006-8993(80)90838-0

Cited by 126 publications

(44 citation statements)

References 17 publications

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“…Post-training injections of d-amphetamine at 1.0 mg/kg (i.p. ), but not 0.25 or 4.0 mg/kg, have been shown to enhance inhibitory avoidance learning (Martinez et al 1980). It is unclear if pre-versus post-training injections would share the same doseresponse curve, so it is difficult to directly compare the results of the Martinez study with the current results.…”

Section: Discussionmentioning

confidence: 80%

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

Wood

Anagnostaras

2008

Psychopharmacology

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Rationale and Objectives-With prescriptions of stimulants on the rise, it is important to examine the cognitive effects of low and moderate doses of stimulants, rather than only those typical of addicts.Methods-The present study examined the effects a range of doses (0.005 -8 mg/kg) of damphetamine sulfate on cued and contextual Pavlovian fear conditioning in mice.Results-In agreement with previous research, subjects administered a moderately high dose of amphetamine (8 mg/kg) pre-training, typical of what addicts might take, displayed impaired memory when tested, off-drug. Alternately, subjects injected with a very low dose of amphetamine (0.005, 0.025, or 0.05 mg/kg), pre-training, similar to the therapeutic doses for attention deficit hyperactivity disorder, displayed enhanced memory when tested, off-drug. A control study showed these effects were not due to state-dependent learning.Conclusions-Thus, dose is a critical determinant of the cognitive effects of psychostimulants.

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Section: Discussionmentioning

confidence: 80%

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

Wood

Anagnostaras

2008

Psychopharmacology

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“…Psychostimulants have been shown to enhance learning and memory (Carmack et al, 2010;Martinez et al, 1980;Soetens et al, 1995;Wood and Anagnostaras, 2009). An understanding of how these drugs initiate enhanced learning and memory is valuable from two perspectives: first, such drugs could be useful as cognitive enhancers in humans with memory impairments, and second, amphetamines as drugs of abuse are believed to produce persistent memory by inducing a type of pathological memory (Berke and Hyman, 2000;Hamilton and Kolb, 2005;Huang et al, 2009;Liu et al, 2005;O'Brien et al, 1992;Robinson and Kolb, 2004;Thomas et al, 2008;Wise, 2000;Wolf et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Methamphetamine enhances memory of operantly conditioned respiratory behavior in the snail Lymnaea stagnalis

Kennedy

Houmes

Wyrick

et al. 2010

Journal of Experimental Biology

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SUMMARYAmphetamines have been used as cognitive enhancers to promote learning and memory. Amphetamines are also drugs of abuse that may promote the initiation of strong memories that ultimately lead to addiction. To understand how methamphetamine (Meth) may be augmenting learning and memory, we chose a relatively simple system, the pond snail, Lymnaea stagnalis. We studied the effects of Meth exposure on the long-term memory (LTM), extinction and reinstatement of operantly conditioned aerial respiratory behavior in Lymnaea. We first determined doses of Meth that would acutely alter respiratory behavior. Next, we measured the impact of training snails in Meth solution or water (control group) using a training procedure that produces LTM (>6h) in control conditions. Meth exposure impaired the expression of LTM 21h after two training sessions, but this appeared to be a context-dependent effect only. However, snails exposed to 3.3mmoll -1 Meth during training had a decreased rate of extinction of the operantly conditioned memory. We then tested whether this decreased ability of snails to extinguish memory was due to enhanced LTM or impaired extinction of that memory. Snails were operantly conditioned in water and exposed to Meth 16h after their last trial but 4-5h prior to extinction. Meth produced an increase rather than a decrease in extinction rate. Thus, Meth impaired extinction only when snails were exposed to Meth during training. Last, we tested the effect of Meth on the ability to form LTM using a single training procedure that is suboptimal for LTM formation. Control snails did not demonstrate LTM, as expected, but pre-exposure of snails to 3.3mmoll -1 Meth 24h prior to the single training session produced LTM 24h later, indicating that Meth pre-exposure primed snails for LTM formation. Taken together, our studies suggest that LTM is strengthened by Meth such that extinction training is less effective. Lymnaea provides a simple and useful model system to dissect the cellular and/or molecular mechanisms of how Meth may initiate the formation of stronger memories.

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“…Numerous studies [e.g. [32][33][34] have shown that amphetamine enhances memory when administered systemically either shortly before, or shortly after training. Enhancing effects of amphetamine have been observed in a variety of tasks, such as IA, active avoidance, discriminated avoidance, and appetitive discrimination [34][35][36].…”

Section: Adrenergic Catecholamines and Memory Storagementioning

confidence: 99%

Role of Norepinephrine in Modulating Inhibitory Avoidance Memory Storage: Critical Involvement of the Basolateral Amygdala

Ferry¹,

Quírarte²

2012

The Amygdala - A Discrete Multitasking Manager

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Central and peripheral actions of amphetamine on memory storage

Cited by 126 publications

References 17 publications

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

Memory and psychostimulants: modulation of Pavlovian fear conditioning by amphetamine in C57BL/6 mice

Methamphetamine enhances memory of operantly conditioned respiratory behavior in the snail Lymnaea stagnalis

Role of Norepinephrine in Modulating Inhibitory Avoidance Memory Storage: Critical Involvement of the Basolateral Amygdala

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