Role of Norepinephrine in Modulating Inhibitory Avoidance Memory Storage: Critical Involvement of the Basolateral Amygdala

Ferry, Barbara; Quírarte, Gina L.

doi:10.5772/53246

Cited by 8 publications

(6 citation statements)

References 162 publications

(189 reference statements)

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“…α 1 -AR blockage in the BLA decreased the stimulation of cAMP through a β-AR agonist or the increased effect of a synthetic cAMP analog on memory storage ( Ferry et al., 1999a ; Ferry et al., 1999b ), while activation of α 1 -ARs can potentiate β-AR-mediated increases in cAMP formation in the BLA to enhance memory storage ( Ferry et al., 1999a ; Ferry et al., 1999b ). Phenylephrine alone impaired memory retention in the BLA but when infused with the α 2 -AR antagonist yohimbine increased memory retention ( Ferry and Quirarte, 2012 ) suggesting that the cross talk of activating presynaptic α 2 -ARs led to the memory impairing effects. KO mice that has the gene deletion for the α 1B -AR indicated a decrease in latency in the passive avoidance test suggesting deficits in memory consolidation ( Knauber and Müller, 2000b ).…”

Section: Memory Consolidation Storage and Recallmentioning

confidence: 99%

α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition

Perez

2020

Front. Pharmacol.

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a 1-adrenergic receptors are G-Protein Coupled Receptors that are involved in neurotransmission and regulate the sympathetic nervous system through binding and activating the neurotransmitter, norepinephrine, and the neurohormone, epinephrine. There are three a 1-adrenergic receptor subtypes (a 1A , a 1B , a 1D) that are known to play various roles in neurotransmission and cognition. They are related to two other adrenergic receptor families that also bind norepinephrine and epinephrine, the band a 2-, each with three subtypes (b 1 , b 2 , b 3 , a 2A , a 2B , a 2C). Previous studies assessing the roles of a 1-adrenergic receptors in neurotransmission and cognition have been inconsistent. This was due to the use of poorly-selective ligands and many of these studies were published before the characterization of the cloned receptor subtypes and the subsequent development of animal models. With the availability of more-selective ligands and the development of animal models, a clearer picture of their role in cognition and neurotransmission can be assessed. In this review, we highlight the significant role that the a 1-adrenergic receptor plays in regulating synaptic efficacy, both short and long-term synaptic plasticity, and its regulation of different types of memory. We will also present evidence that the a 1-adrenergic receptors, and particularly the a 1A-adrenergic receptor subtype, are a potentially good target to treat a wide variety of neurological conditions with diminished cognition.

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Section: Memory Consolidation Storage and Recallmentioning

confidence: 99%

α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition

Perez

2020

Front. Pharmacol.

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“…Beta- and α-adrenoceptor subtypes are expressed at high levels in the amygdala (see ref for review). NE release in the BLA has complex effects including direct alteration of pyramidal projection neurons (PN) excitability and presynaptic modulation of GABA release from interneurons. − First, noradrenergic signaling modulates excitatory transmission in the BLA via activation of postsynaptic β- and α 1 -adrenoceptors onto excitatory PN and via α 2 -adrenoceptors, which inhibit PN excitability. , Second, local inhibitory feed-back projecting interneurons make perisomatic synapses on PN .…”

Section: Resultsmentioning

confidence: 99%

Microdialysis Unveils the Role of the α₂-Adrenergic System in the Basolateral Amygdala during Acquisition of Conditioned Odor Aversion in the Rat

Estrade

Cassel

Parrot

et al. 2018

ACS Chem. Neurosci.

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Previous work has shown that β-adrenergic and GABAergic systems in the basolateral amygdala (BLA) are involved in the acquisition of conditioned odor aversion (COA) learning. The involvement of α-adrenoreceptors, however, is poorly documented. In a first experiment, male Long-Evans rats received infusions of 0.1 μg of the selective α-antagonist dexefaroxan (Dex) in the BLA before being exposed to COA learning. In a second experiment, levels of norepinephrine (NE) were analyzed following Dex retrodialysis into the BLA. While microdialysis data showed a significant enhancement of NE release in the BLA with Dex, behavioral results showed that pre-CS infusion of Dex impaired, rather than facilitated, the acquisition of COA. Our results show that the NE system in the BLA is involved in the acquisition of COA, including a strong α-receptor modulation until now unsuspected. Supported by the recent literature, the present data suggest moreover that the processes underlying this learning are probably mediated by the balanced effects of NE excitatory/inhibitory signaling in the BLA, in which interneurons are highly involved.

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“…The basolateral nucleus of the amygdala (BLA) can also be involved in the storage and consolidation of memory ( Ferry and McGaugh, 2000 ). As cAMP signaling is mainly involved in mediating the effects of norepinephrine on memory consolidation, the β-ARs were previously considered the main AR to transduce those effects ( Ikegaya et al, 1997 ; Ferry and McGaugh, 2000 ; Ferry and Quirarte, 2012 ). However, both β- and α 1 -ARs may be needed together to mediate memory storage in the BLA.…”

Section: Cognitionmentioning

confidence: 99%

Current Developments on the Role of α1-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism

Perez

2021

Front. Cell Dev. Biol.

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The α1-adrenergic receptors (ARs) are G-protein coupled receptors that bind the endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the regulation of the sympathetic nervous system along with β and α2-AR family members. While all of the adrenergic receptors bind with similar affinity to the catecholamines, they can regulate different physiologies and pathophysiologies in the body because they couple to different G-proteins and signal transduction pathways, commonly in opposition to one another. While α1-AR subtypes (α1A, α1B, α1C) have long been known to be primary regulators of vascular smooth muscle contraction, blood pressure, and cardiac hypertrophy, their role in neurotransmission, improving cognition, protecting the heart during ischemia and failure, and regulating whole body and organ metabolism are not well known and are more recent developments. These advancements have been made possible through the development of transgenic and knockout mouse models and more selective ligands to advance their research. Here, we will review the recent literature to provide new insights into these physiological functions and possible use as a therapeutic target.

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Role of Norepinephrine in Modulating Inhibitory Avoidance Memory Storage: Critical Involvement of the Basolateral Amygdala

Cited by 8 publications

References 162 publications

α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition

α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition

Microdialysis Unveils the Role of the α₂-Adrenergic System in the Basolateral Amygdala during Acquisition of Conditioned Odor Aversion in the Rat

Current Developments on the Role of α1-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism

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Role of Norepinephrine in Modulating Inhibitory Avoidance Memory Storage: Critical Involvement of the Basolateral Amygdala

Cited by 8 publications

References 162 publications

α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition

α1-Adrenergic Receptors in Neurotransmission, Synaptic Plasticity, and Cognition

Microdialysis Unveils the Role of the α2-Adrenergic System in the Basolateral Amygdala during Acquisition of Conditioned Odor Aversion in the Rat

Current Developments on the Role of α1-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism

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Microdialysis Unveils the Role of the α₂-Adrenergic System in the Basolateral Amygdala during Acquisition of Conditioned Odor Aversion in the Rat