Central 5-HT3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss

Voronova, Irina P.; Науменко, В. С.; Khramova, G. M.; Козырева, Т. В.; Попова, Н. К.

doi:10.1016/j.neulet.2011.09.024

Cited by 10 publications

(11 citation statements)

References 31 publications

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“… 39 During spinal anaesthesia, vasodilatation and redistribution of the core temperature are restricted to the lower body below the level of the block, while vasoconstriction and shivering are restricted to the upper body. 40 Voronova et al 41 suggested that the activation of central 5-HT3 receptors is more effective in hypothermia induction due to a marked decrease in thermogenesis and increased heat loss, indicating that 5-HT3-associated pathways may play an important role in controlling shivering. The mechanism of 5-HT3 receptor antagonists to prevent chills might be related to the inhibition of neurotransmission required for hypothalamic temperature regulation.…”

Section: Discussionmentioning

confidence: 99%

5-HT₃receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

Shen

Li²,

Zhou

et al. 2020

BMJ Open

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ObjectivePerioperative shivering (POS) is a common complication in patients undergoing spinal anaesthesia. The present study investigated the efficacy of 5-HT3 receptor antagonists in preventing POS following spinal anaesthesia.DesignSystematic review and meta-analysis.Data sourcesPubmed, Embase, the Web of Science and Cochrane Library were searched from database establishment on 31 July 2019.Eligibility criteriaRandomised controlled trials that reported the effects of 5-HT3 receptor antagonists in the prevention of POS in patients after spinal anaesthesia.Data extraction and synthesisTwo reviewers independently extracted data. The primary outcome of the present study was the incidence of POS. The risk of bias for the included studies was assessed according to the Cochrane Handbook. The quality of primary outcome was evaluated by Grading of Recommendations Assessment, Development and Evaluation. Trial sequential analysis for the primary outcome was performed to reduce the type 1 error caused by repeated meta-analysis and the required information size was calculated.ResultsA total of 13 randomised controlled trials consisting of 1139 patients were included. The overall incidence of POS was significantly lower in the 5-HT3 receptor antagonists group (risk ratio 0.31; 95% CI 0.26 to 0.38; p<0.01; I2=0%). Subgroup analysis for different types of 5-HT3 receptor antagonists and timing of administration produced similar results. Also, patients had a lower incidence of postoperative nausea and vomiting after administrating 5-HT3 receptor antagonists. No statistically significant differences in drug-related adverse effects were observed. Grading of Recommendations Assessment, Development and Evaluation revealed a high level of evidence. The cumulative z-curve crossed the trial sequential monitoring boundary.ConclusionsThe present study revealed that prophylactic 5-HT3 receptor antagonists were an effective measure for reducing the incidence of POS in patients after spinal anaesthesia. However, further studies investigating the different types of surgeries are required.PROSPERO registration numberCRD42019148191.

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Section: Discussionmentioning

confidence: 99%

5-HT₃receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

Shen

Li²,

Zhou

et al. 2020

BMJ Open

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“…Direct injection of serotonin into the anterior preoptic area of the hypothalamus or electrical stimulation of the dorsal raphe to release serotonin from the nerve terminals elicits hypothermia, whereas direct injection of serotonergic antagonists (e.g., methysergide, cyproheptadine) into this region produces hyperthermia; these changes in body temperature result from alterations in metabolism and vasodilation/constriction of the blood vessels in the skin (Lin et al, 1983). Activation of 5-HT 1A and 5-HT 3 receptors in the brain also elicits hypothermia (Voronova et al, 2011). Since the aforementioned antagonists (methysergide, cyproheptadine) attenuate 5-HT 2 receptor signaling, it appears that multiple serotonin receptor subtypes participate in central thermoregulatory processes.…”

Section: Pharmacological and Molecular Biological Studies Of Meth mentioning

confidence: 99%

Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

Matsumoto

Seminerio

Turner

et al. 2014

Pharmacology & Therapeutics

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Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine.

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“…Although Ootsuka and Blessing 35) reported an effect of the 5-HT1A receptor agonist 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) on thermoregulation, Naumenko et al 38) reported that the 5-HT7 receptor agonist LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) induced a greater Tb decrease than 8-OH-DPAT. Voronova et al 39) also reported that the 5-HT3 receptor agonist m-CPBG (1-(3-chlorophenyl)biguanide hydrochloride) administered intracerebroventricularly resulted in a decrease in Tb. These results further demonstrated the involvement of central rather than peripheral 5-HT receptors in thermoregulation, and that both an increase in heat loss and decrease of heat production underlie the lower Tb.…”

Section: Recent Research On 5-ht and Thermoregulation In Resting Condmentioning

confidence: 99%

“…Many studies have focused on the role of 5-HT1A receptors in influencing Tb. Selective agonists of 5HT1A receptors produce a considerable hypothermic response [33][34][35][36][37][38][39] . It was further shown that 5-HT1A receptor activation has effects on both heat loss 40,41) and heat production 34,35) .…”

Section: Recent Research On 5-ht and Thermoregulation In Resting Condmentioning

confidence: 99%

Role of serotonergic system in thermoregulation in rats

Ishiwata

2014

JPFSM

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The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) is involved in the regulation of several basic physiological functions such as hormone secretion, sleep-wake cycle, motor control, immune system functioning, nociception, food intake, energy balance and thermoregulation. In addition, 5-HT participates in higher brain functions, such as cognition and emotional states, by modulating synaptic plasticity and neurogenesis. Furthermore, 5-HT has recently captured the spotlight in connection with depression, synthetic narcotic drugs, hot flash, central fatigue, etc. Regarding thermoregulation, many studies have examined the relationship between 5-HT and body temperature (Tb) regulation since the 1960s. Feldberg and Myers, in pioneering experiments, first reported that microinjection of 5-HT into the cerebral ventricles or hypothalamus induced a rise in Tb. Subsequently, research on 5-HT and regulation of Tb continued and topics in recent years include resolving of 5-HT receptor subtypes, such as 5-HT 1A , 5-HT 3 , 5-HT 7 , and pinpointing a local area or network for thermoregulation. In this short review, I first outline the serotonergic system in the brain, summarize the history of research on 5-HT and thermoregulation, and finally focus on recent research in the 21 st century.

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Central 5-HT3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss

Cited by 10 publications

References 31 publications

5-HT₃receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

5-HT₃receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

Role of serotonergic system in thermoregulation in rats

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Central 5-HT3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss

Cited by 10 publications

References 31 publications

5-HT3receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

5-HT3receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

Methamphetamine-induced toxicity: An updated review on issues related to hyperthermia

Role of serotonergic system in thermoregulation in rats

Contact Info

Product

Resources

About

5-HT₃receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

5-HT₃receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials