Role of serotonergic system in thermoregulation in rats

Ishiwata, Takayuki

doi:10.7600/jpfsm.3.445

Cited by 11 publications

(5 citation statements)

References 55 publications

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“…The change in body temperature of warm-blooded organisms is also one of its physiological effects. 5-HT receptors that definitely influence the body temperature of a warm-blooded organism are the following: the 5-HT receptor of the 1A type (5-HT 1A ), the 5-HT receptor of the 2 type (5-HT 2 ), the 5-HT receptor of the 3 type (5-HT 3 ), and the 5-HT receptor of the 7 type (5-HT 7 ) [ 18 , 19 , 27 , 30 , 31 ]. The present article focuses solely on these receptors and their role in body temperature maintenance of warm-blooded organisms.…”

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confidence: 99%

5-HT Receptors and Temperature Homeostasis

Voronova

2021

Biomolecules

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The present review summarizes the data concerning the influence of serotonin (5-HT) receptors on body temperature in warm-blooded animals and on processes associated with its maintenance. This review includes the most important part of investigations from the first studies to the latest ones. The established results on the pharmacological activation of 5-HT1A, 5-HT3, 5-HT7 and 5-HT2 receptor types are discussed. Such activation of the first 3 type of receptors causes a decrease in body temperature, whereas the 5-HT2 activation causes its increase. Physiological mechanisms leading to changes in body temperature as a result of 5-HT receptors’ activation are discussed. In case of 5-HT1A receptor, they include an inhibition of shivering and non-shivering thermogenesis, as well simultaneous increase of peripheral blood flow, i.e., the processes of heat production and heat loss. The physiological processes mediated by 5-HT2 receptor are opposite to those of the 5-HT1A receptor. Mechanisms of 5-HT3 and 5-HT7 receptor participation in these processes are yet to be studied in more detail. Some facts indicating that in natural conditions, without pharmacological impact, these 5-HT receptors are important links in the system of temperature homeostasis, are also discussed.

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confidence: 99%

5-HT Receptors and Temperature Homeostasis

Voronova

2021

Biomolecules

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“…Du ( 54 ) reported that the blood IL-6 have decreased in the heat-stress healing group. Additionally, 5-HT plays a key role in the central thermoregulatory system ( 55 ). There were no differences in plasma HSP-70, HSP-90, GLU, IL-6, PRL, and 5-HT between HTDC and HSDC in this study.…”

Section: Discussionmentioning

confidence: 99%

Effects of heat stress on endocrine, thermoregulatory, and lactation capacity in heat-tolerant and -sensitive dry cows

Chen,

Li,

Fang

et al. 2024

Front. Vet. Sci.

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IntroductionIncreasing global temperatures present a significant challenge to livestock production. The dry period is an important stage in the production cycle of cow, and environmental heat stress (HS) during this period can have adverse effects on the subsequent lactation performance. In this study, we aimed to investigate the effects of HS on endocrine, thermoregulatory, and lactation parameters in heat-tolerant dry cows (HTDC) and heat-sensitive dry cows (HSDC).MethodsWe measured the respiratory rate (RR), body temperature (BT), and temperature-humidity index (THI) in 66 dry cows during HS. The slopes of RR and BT to THI were determined through analysis of measurements and dry cows background information using a mixed-effects model. Subsequently, the heat tolerance or sensitivity of dry cows was assessed using clustering method (HTDC = 19 and HSDC = 47).ResultsCompared with that of HSDC, the RR of HTDC significantly increased after exposure to HS (p < 0.05). The average reduction in milk yield from new lactation to the previous lactation was significantly lower in HTDC compared to HSDC (p < 0.05). Plasma cortisol and non-esterified fatty acid levels were significantly lower in HTDC compared to HSDC (p < 0.05), while plasma triiodothyronine (p = 0.07) and growth hormone (p = 0.08) levels tended to be higher in HTDC relative to HSDC.DiscussionHTDC can more effectively alleviate the impacts of HS through their superior thermoregulation and metabolism, thereby ensuring optimal postpartum lactation performance.

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“…In our experiment, the heat-tolerant cows had the same result. The central nervous system regulates the reactions of thermoregulatory effectors, such as cutaneous circulation, brown adipose tissue, and sweat glands, to external temperature challenges; 5-HT is thought to play a key function in this core thermoregulatory system [ 43 ]. In the rat hypothalamus, short-term HS accelerates 5-HT metabolism and increases the expression of 5-HT receptor genes [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Heat Stress on Blood, Production, and Physiological Indicators in Heat-Tolerant and Heat-Sensitive Dairy Cows

Chen

Shu

Sun

et al. 2023

Animals

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Heat stress affects production and health in cows severely. Since it is difficult to define heat-tolerant animals, studies of response to heat stress are important for understanding dairy cows’ health and production. However, information on the impact of heat stress on various indicators in heat-tolerant and heat-sensitive cows is sparse. This study aimed to investigate the effects of heat stress (HS) on blood, production, and physiological indicators in heat-tolerant and heat-sensitive cows. A total of 43 dairy cows were used from 9 May to 7 August 2021, under Temperature–Humidity Index (THI) measurements that ranged from 65.9 to 86.7. We identified cows that were tolerant or sensitive to HS based on the slope of the response of physiological and production traits against THI during the HS period by using a clustering method. After HS, serum glucose (Glu), cortisol (COR), 5-hydroxytryptamine (5-HT), and interleukin-6 (IL-6) levels of cows in the heat-tolerant group were lower than in the heat-sensitive group (p < 0.05). With THI as the predictor, the R2 for predicting respiration rate (RR) and body surface temperature (BT) in heat-tolerant cows was 0.15 and 0.16, respectively, whereas the R2 for predicting RR and BT in heat-sensitive cows was 0.19 and 0.18, respectively. There were low to moderate, positive correlations between RR, BT, and MY with THI, with Pearson correlation coefficients ranging from r = 0.11 to 0.4 in the heat-tolerant group, and from r = 0.24 to 0.43 in the heat-sensitive group. There was a low positive correlation between VT and THI, with a Spearman correlation coefficient of r = 0.07 in the heat-sensitive group. The heat-tolerant dairy cows had lower MY losses and had lower MY (p = 0.0007) in mixed models. Heat-tolerant cows with low-stress levels, through upregulating RR rapidly, increased their adaptability to thermal environments. They have better thermoregulation capability; the hypothalamic–pituitary–adrenal (HPA) axis regulated the thermoregulatory in animals by releasing a variety of neurotransmitters and hormones.

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Role of serotonergic system in thermoregulation in rats

Cited by 11 publications

References 55 publications

5-HT Receptors and Temperature Homeostasis

5-HT Receptors and Temperature Homeostasis

Effects of heat stress on endocrine, thermoregulatory, and lactation capacity in heat-tolerant and -sensitive dry cows

Impact of Heat Stress on Blood, Production, and Physiological Indicators in Heat-Tolerant and Heat-Sensitive Dairy Cows

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