Centaurea hypoleuca DC: Phenolic content, antimicrobial, antioxidant and enzyme inhibitory activities

Özcan, Kadriye; Acet, Tuba; Çorbacı, Cengiz

doi:10.1016/j.sajb.2019.10.020

Cited by 25 publications

(17 citation statements)

References 22 publications

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“…In the study of Lahneche et al [99] n-butanol extracts of C. sphaerocephala which were richer in total phenolics and flavonoids exhibited higher antioxidant activity than other extracts. Moreover, several other reports tested the antioxidant activity of Centaurea species through various assays highlighting the potential role of different phytochemicals in such activities and the possible use of these species in human diet as antioxidant agents [86,[100][101][102][103][104].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds

et al. 2020

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Centaurea raphanina subsp. mixta (DC.) Runemark is a wild edible species endemic to Greece. This study evaluated the chemical composition and bioactive properties of wild and cultivated C. raphanina subsp. mixta plants. Wild plants had higher nutritional value than cultivated ones, whereas cultivated plants contained more tocopherols. Glucose and sucrose were higher in cultivated plants and trehalose in wild ones. Oxalic and total organic acids were detected in higher amounts in cultivated samples. The main fatty acids were α-linolenic, linoleic and palmitic acid, while wild plants were richer in polyunsaturated fatty acids. Two pinocembrin derivatives were the main phenolic compounds being detected in higher amounts in wild plants. Regarding the antioxidant activity, wild and cultivated plants were more effective in the oxidative haemolysis (OxHLIA) and thiobarbituric acid reactive substances (TBARS) assays, respectively. Moreover, both extracts showed moderate cytotoxicity in non-tumor cell lines (PLP2), while cultivated plants were more effective against cervical carcinoma (HeLa), breast carcinoma (MCF-7) and non-small lung cancer (NCI-H460) cell lines. Finally, wild plants showed higher antimicrobial activity than cultivated plants against specific pathogens. In conclusion, the cultivation of C. raphanina subsp. mixta showed promising results in terms of tocopherols content and antiproliferative effects, however further research is needed to decrease oxalic acid content.

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Section: Antioxidant Activitymentioning

confidence: 99%

Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds

et al. 2020

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“…So far, there are several reports that refer to the chemical composition and bioactive properties of Centaurea species, most of which study wild plants collected from their natural environments [18,[29][30][31][32]. The most interesting compounds reported in this genus are sesquiterpene lactones [33,34], while it also contains phenolic compounds [30,35], tocopherols [36] and fatty acids [37,38]. Centaurea raphanina subsp.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Plant Growth of Centaurea raphanina subsp. mixta Plants Cultivated under Saline Conditions

et al. 2020

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The aim of this report was to study the effect of salinity (control: 2dS/m, S1: 4 dS/m and S2: 6 dS/m) and harvest time (first harvest on 9 May 2018 and second harvest on 19 April 2018) on the growth and the chemical composition of Centaurea raphanina subsp. mixta plants. The plants of the first harvest were used for the plant growth measurements (fresh weight and moisture content of leaves, rosette diameter, number and thickness of leaves), whereas those of the second harvest were not used for these measurements due to the flowering initiation, which made the leaves unmarketable due to their hard texture. The results of our study showed that C. raphanina subsp. mixta plants can be cultivated under mild salinity (S1 treatment) conditions without severe effects on plant growth and yield, since a more severe loss (27.5%) was observed for the S2 treatment. In addition, harvest time proved to be a cost-effective cultivation practice that allows to regulate the quality of the final product, either in edible form (first harvest) or for nutraceutical and pharmaceutical purposes as well as antimicrobial agents in food products. Therefore, the combination of these two agronomic factors showed interesting results in terms of the quality of the final product. In particular, high salinity (S2 treatment) improved the nutritional value by increasing the fat, proteins and carbohydrates contents in the first harvest, as well as the tocopherols and sugars contents (S1 and S2 treatments, respectively) in the second harvest. In addition, salinity and harvest time affected the oxalic acid content which was the lowest for the S2 treatment at the second harvest. Similarly, the richest fatty acid (α-linolenic acid) increased with increasing salinity at the first harvest. Salinity and harvest time also affected the antimicrobial properties, especially against Staphylococcus aureus, Bacillus cereus and Trichoderma viride, where the extracts from the S1 and S2 treatments showed high effectiveness. In contrast, the highest amounts of flavanones (pinocembrin derivatives) were detected in the control treatment (second harvest), which was also reflected to the highest antioxidant activity (TBARS) for the same treatment. In conclusion, C. raphanina subsp. mixta plants seem to be tolerant to medium salinity stress (S1 treatment) since plant growth was not severely impaired, while salinity and harvesting time affected the nutritional value (fat, proteins, and carbohydrates) and the chemical composition (tocopherols, sugars, oxalic acid, fatty acids), as well as the bioactive properties (cytotoxicity and antimicrobial properties) of the final product.

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“…e phytochemical analysis of C. calcitrapa proved the presence of sterols, sesquiterpene lactones, and their closely related group of triterpenoids, bisabolenes, lignans, and flavonoids as the main secondary metabolites [124][125][126][127][128][129][130]. C. hypoleuca contains higher amounts of catechin and chlorogenic acid than the other phenolic compounds, which are known to be responsible for various biological activities such as antioxidant, neuroprotective, antidiabetic, hepatoprotective, and antiarthritic properties [72,[147][148][149]. High levels of apigenin (2472 μg/g extract), known as a common dietary flavonoid, has absorbed attention in C. saligna.…”

Section: Phenolic Compounds Phenolic Compounds Havementioning

confidence: 99%

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

Fattaheian-Dehkordi

Hojjatifard

Saeedi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Diabetes mellitus (DM) is a long-life metabolic disorder, characterized by high blood glucose levels. The hyperglycemic condition generally leads to irreversible nerve injury and vascular damage. Among different types of diabetes, type 2 is more common and has spread all over the world. Although various therapeutic approaches have been developed to control type 2 DM, regulating blood glucose levels has still remained a controversial challenge for patients. Also, most prescription drugs cause different side effects, such as gastrointestinal disorders. Thus, developing novel and efficient antidiabetic agents possessing fewer adverse effects is in high demand. Method. The literature was comprehensively surveyed via search engines such as Google Scholar, PubMed, and Scopus using appropriate keywords. Results. Medicinal plants, both extracts and isolated active components, have played a significant role in controlling the blood glucose levels. Good-to-excellent results documented in the literature have made them a precious origin for developing and designing drugs and supplements against DM. Centaurea spp. have been traditionally used for controlling high blood glucose levels. Also, the antidiabetic properties of different species of Centaurea have been confirmed in recent studies through in vitro assays as well as in vivo experiments. Conclusion. Potent results encouraged us to review their efficacy to open a new horizon for development of herbal antidiabetic agents.

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Centaurea hypoleuca DC: Phenolic content, antimicrobial, antioxidant and enzyme inhibitory activities

Cited by 25 publications

References 22 publications

Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds

Wild and Cultivated Centaurea raphanina subsp. mixta: A Valuable Source of Bioactive Compounds

Chemical Composition and Plant Growth of Centaurea raphanina subsp. mixta Plants Cultivated under Saline Conditions

A Review on Antidiabetic Activity of Centaurea spp.: A New Approach for Developing Herbal Remedies

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