Cementogenesis reviewed: A comparison between human premolars and rodent molars

Bosshardt, Dieter D.; Schroeder, Hubert E.

doi:10.1002/(sici)1097-0185(199606)245:2<267::aid-ar12>3.0.co;2-n

Cited by 202 publications

(147 citation statements)

References 101 publications

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“…The root formation in rats is 17–20 times faster than in humans [7]. This implies that 9- to 12-month-old rat specimens when compared to 40- to 55-year-old humans could be significantly more mineralized, as suggested from this study.…”

Section: Discussionmentioning

confidence: 51%

“…Additionally the genetic, clinical radiographic and histological aspects of the rat periodontium are similar to the human periodontium [2,3]. The similarities published to date include the cementum structure [4–7], accumulation of significant amounts of cementum at the apical end with age, and localization of proteoglycans within cementum, dentin [5,6,8–12] and the cementum–dentin interface [13]. Although there is some information about cementum structure and its attachment to root dentin [5,6], little is known about the correlation between structure, chemical composition and mechanical properties of cementum and the cementum–dentin interface with root dentin in rat molars.…”

Section: Introductionmentioning

confidence: 99%

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Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin

Yun³

et al. 2009

Acta Biomaterialia

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This work seeks to establish comparisons of the physical properties of rat and human cementum, root dentin and their interface, including the cementum-dentin junction (CDJ), as a basis for future studies of the entire periodontal complex using rats as animal models. In this study the structure, sitespecific chemical composition and mechanical properties of cementum and its interface with root dentin taken from 9-to 12-month-old rats were compared to the physiologically equivalent 40-to 55-year-old human age group using qualitative and quantitative characterization techniques, including histology, atomic force microscopy (AFM), micro-X-ray computed tomography, Raman microspectroscopy and AFM-based nanoindentation. Based on results from this study, cementum taken from the apical third of the respective species can be represented as a woven fabric with radially and circumferentially oriented collagen fibers. In both species the attachment of cementum to root dentin is defined by a stiffness-graded interface (CDJ/cementum-dentin interface). However, it was concluded that cementum and the cementum-dentin interface from a 9-to 12-month-old rat could be more mineralized, resulting in noticeably decreased collagen fiber hydration and significantly higher modulus values under wet conditions for cementum and CDJ (E rat-cementum = 12.7 ± 2.62 GPa; E rat-CDJ = 11.6 ± 3.20 GPa) compared to a 40-to 55-year-old human (E human-cementum = 3.73 ± 1.81 GPa; E human-CDJ = 1.5 ± 0.71 GPa). The resulting data illustrated that the extensions of observations made from animal models to humans should be justified with substantial and equivalent comparison of data across age ranges (life spans) of mammalian species.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin

Yun³

et al. 2009

Acta Biomaterialia

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“…As previously reported, a genetically manipulated mouseis an excellent model tostudy odontogenesisbecause of its fast growth rate. However, with regard to cementogenesis,the rodent molar does not provide a good parallel for the human situation[38]. …”

Section: Discussionmentioning

confidence: 99%

Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse

et al. 2017

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Cathepsin K (CTSK) is a member of cysteine proteinase family, and is predominantly expressed in osteoclastsfor degradationof bone matrix proteins. Given the similarity in physical properties of bone and dental mineralized tissues, including enamel, dentin and cementum, CTSK is likely to take part in mineralization process during odontogenesis. On the other hand, patients with pycnodysostosis caused by mutations of the CTSK gene displayedmultipledental abnormalities, such as hypoplasia of the enamel, obliterated pulp chambers, hypercementosis and periodontal disease. Thereforeitis necessary to study the metabolic role of CTSK in tooth matrix proteins. In this study, BALB/c mice at embryonic day 18 (E18), post-natal day 1 (P1), P5, P10 and P20 were used (5 mice at each time point)for systematic analyses of CTSK expression in the late stage of tooth germ development. We found that CTSK was abundantly expressed in the ameloblasts during secretory and maturation stages (P5 and P10) by immunohistochemistry stainings.During dentinogenesis, the staining was also intense in the mineralization stage (P5 and P10),but not detectable in the early stage of dentin formation (P1) and after tooth eruption (P20).Furthermore, through zymography and digestion test in vitro, CTSK was proved to be capable of hydrolyzing Emdogain and also cleaving Amelogenininto multiple products. Our resultsshed lights on revealing new functions of CTSK and pathogenesis of pycnodysostosis in oral tissues.

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“…In addition to this differentiation of the DF to form the fibroblasts of the PDL, it has been postulated that some DF cells may differentiate into the cementoblasts of the tooth, as well as perhaps some of the osteoblasts of the alveolar bone ( e.g. , see review by Bosshardt and Schroeder, 1996). Although some studies suggest that some of the cementoblasts may arise from Hertwig’s epithelial root sheath, as well as from the DF (Zeichner-David et al , 2003), other studies indicate that all of the cementoblasts arise from the DF (Diekwisch, 2001).…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Stem Cells in the Dental Follicle

et al. 2008

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The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells were identified in the DF of the rat first mandibular molar by Hoechst staining, alkaline phosphatase staining, and expression of side-population stem cell markers. These cells were shown to be able to differentiate into osteoblasts/cementoblasts, adipocytes, and neurons. Treating the DF cell population with doxorubicin, followed by incubation in an adipogenesis medium, suggested that the adipocytes originated from stem cells. Thus, a possibly puripotent stem cell population is present in the rat DF.

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Cementogenesis reviewed: A comparison between human premolars and rodent molars

Cited by 202 publications

References 101 publications

Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin

Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin

Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse

Differentiation of Stem Cells in the Dental Follicle

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