Cement particles inhibit bone growth into titanium chambers implanted in the rabbit

Goodman, Stuart B.; Aspenberg, Per; Wang, Jiansheng; Song, Yong; Doshi, Akash; Regula, Donald; Emmanual, Janson; Lidgren, Lars

doi:10.3109/17453679308994585

Cited by 24 publications

(16 citation statements)

References 24 publications

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“…Furthermore, there are no significant differences in bone formation between the carrier alone and particles with or without ZrO 2 in the chamber. This result is not in agreement with a previous study that shows bone cement particles decrease the formation of new bone in a bone harvest chamber (Goodman et al 1993). However, in that study, Simplex P containing BaSO 4 was used.…”

Section: Discussioncontrasting

confidence: 96%

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In vitro and in vivo biological responses to a novel radiopacifying agent for bone cement

Wang

Diaz

Sabokbar

et al. 2005

J. R. Soc. Interface.

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Iodixanol (IDX) and iohexol (IHX) have been investigated as possible radiopacification agents for polymethylmethacrylate (PMMA) bone cement, to replace the currently used barium sulphate and zirconia. IDX and IHX are both water-soluble iodine-based contrast media and for the last 20 years have been used extensively in clinical diagnostic procedures such as contrast media enhanced computed tomography, angiography and urography. One of the major reasons to remove the current radiopacifying agents is their well-documented cytotoxicity and their potential to increase bone resorption.Using in vitro bone resorption assays, the effect of PMMA particles plus IDX or IHX to induce osteoclast formation and lacunar resorption on dentine slices has been investigated. These responses have been compared with the in vitro response to PMMA particles containing the conventional radiopacifying agents, that is, barium sulphate and zirconia. In parallel, the in vivo reaction, in terms of new bone formation, to particles of these materials has been tested using a bone harvest chamber in rabbit tibiae.In vitro cell culture showed that PMMA containing IHX resulted in significantly less bone resorption than PMMA containing the conventional opacifiers. In vivo testing, however, showed no significant differences between the amounts of new bone formed around cement samples containing the two iodine-based opacifying agents in particulate form, although both led to fewer inflammatory cells than particles of PMMA containing zirconia. Our results suggest that a non-ionic radiopacifier could be considered as an alternative to the conventional radiopacifying agents used in biomaterials in orthopaedic surgery.

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Section: Discussioncontrasting

confidence: 96%

“…This model has been used to assess the effects of biomaterials as solids and particles, including bone cement, polyethylene, titanium alloy, cobalt-chrome and hydroxyapatite particles on bone formation (Goodman et al 1993(Goodman et al , 1996(Goodman et al , 1999Goodman 1994;Wang et al 1994).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo biological responses to a novel radiopacifying agent for bone cement

Wang

Diaz

Sabokbar

et al. 2005

J. R. Soc. Interface.

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“…However, this foreign-body cell reaction was not associated with granuloma formation and did not prevent new bone formation as nonbioactive particles do. 17,18 The intensity of the inflammatory reaction was rated higher with COMP than with BCP, which could be expected from the dissociation of the ceramic particles into smaller grains, observed in the composite paste. 19 The degradation process of the composite and of BCP did not follow the same pattern.…”

Section: Discussionmentioning

confidence: 94%

Long-term bone response to particulate injectable ceramic

Dupraz¹,

Delécrin²,

Moreau³

et al. 1998

J. Biomed. Mater. Res.

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Biphasic calcium phosphate particles (BCP), alone or combined with a cellulosic ether vehicle in an injectable composite material (COMP), were implanted in femurs of rabbits. The long-term follow-up (up to 78 weeks) indicated: (1) BCP and COMP induced a foreign-body inflammatory reaction but without fibrous encapsulation. Phagocytosis was mediated by mononucleated macrophages (MC) and giant multinucleated cells (GMNC). Phagocytosis was stronger with COMP and required the recruitment of GMNC while it primarily involved MC in the case of BCP. (2) There appeared to be no significant difference between the bone ingrowth in the defects packed with BCP (dBCP) and in those filled with COMP (dCOMP). Bone reconstruction mostly was achieved after 4 weeks in dBCP but took more time to reach the center of dCOMP. High bone remodeling was observed at the last evaluation times, especially in the case of COMP. (3) Degradation of the materials occurred mainly during the first 4 weeks and was more severe for COMP, which probably was related to the smaller granulometry of its mineral phase. Cell-mediated degradation went on for the 78 weeks and followed two processes: phagocytosis and/or extracellular dissolution of the calcium phosphate particles.

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“…Small phagocytosable particles of bone cement have been shown to depress the ingrowth of bone into the chamber. 30 In this study, we investigate the effects of small, phagocytosable particles of titanium 6-aluminum 4-vanadium (Ti6A14V) alloy and high-density polyethylene (HDPE) on tissue ingrowth into the BHC implanted in the rabbit tibia.…”

Section: Introductionmentioning

confidence: 99%

Effects of particulate high‐density polyethylene and titanium alloy on tissue ingrowth into bone harvest chamber in rabbits

Goodman

Aspenberg

Song

et al. 1995

J of Applied Biomaterials

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The purpose of this study was to determine whether small, phagocytosable particles of titanium alloy (Ti) and high-density polyethylene (HDPE) have an adverse effect on bone ingrowth. The bone harvest chamber (BHC) was implanted bilaterally in the proximal tibial metaphysis of six mature rabbits. The BHC has a transverse 1-mm wide pore providing a continuous canal through the chamber for tissue ingrowth. After an initial 6-week period for osseointegration of the BHC, the contents of the canal were harvested repeatedly at 3 weekly intervals. This could be done with the chamber in place, without disturbing its exterior surface or the surrounding bone. The carrier solution, 1% sodium hyaluronate (Healon) was implanted first. In subsequent implantations, Healon was mixed with particles of HDPE or Ti averaging 4.7 +/- 2.1 and 3.0 +/- 2.6 microns, respectively. The contralateral chamber was left empty and served as a control. The chambers were harvested repeatedly, alternating experimental and control sides. The sections from the control side, and those containing Healon alone demonstrated extensive trabecular bone in a fibrovascular stroma. The sections containing Ti alloy particles were qualitatively and quantitatively similar to the control sections and those containing Healon, except for the presence of small black granules of Ti alloy, dispersed in the fibrovascular stroma or phagocytosed by scattered macrophages. The sections containing HDPE particles were infiltrated and engulfed by mononuclear and multinuclear histiocytic cells in a highly fibrous stroma. The majority of the multinucleated cells present were interpreted as being foreign body giant cells.(ABSTRACT TRUNCATED AT 250 WORDS)

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Cement particles inhibit bone growth into titanium chambers implanted in the rabbit

Cited by 24 publications

References 24 publications

In vitro and in vivo biological responses to a novel radiopacifying agent for bone cement

In vitro and in vivo biological responses to a novel radiopacifying agent for bone cement

Long-term bone response to particulate injectable ceramic

Effects of particulate high‐density polyethylene and titanium alloy on tissue ingrowth into bone harvest chamber in rabbits

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