“…[7][8][9][10] Some of these metabolites have been confirmed to play important ecological roles in the life cycle of the corals, such as antifeeding, antifouling, and allelopathy properties, [9][10][11][12] while many of them are also described for biological activities of pharmacological significance, such as antitumor, antiviral, antimicrobial, and antiinflammatory activities. [1][2][3][4][5][6][7][8] All these findings indicate that natural cembranoids of marine origin still merit continuous attention for biomedical research. As part of an ongoing project to search for bioactive natural products from Lobophytum corals inhabited in South China Sea, [13][14][15][16][17] a Hainan soft coral, Lobophytum sp., has been chemically investigated based on the EtOAc extract containing high amounts of terpenoids as detected by 1 resulted in the isolation and characterization of four new 7,8-epoxycembranoids, namely (2S*,7S*,8S*,12R*,1Z,3E,10E)-7,8:2,16-diepoxycembra-1(15),3,10-trien-12-ol (1), (2S*,7S*, 8S*,11R*,1Z,3E)-7,8:2,16-diepoxycembra-1(15), 3,12(20)-trien-11-ol (2), (4S*,7S*,8S*,1Z,2E,11E)-16-acetoxy-7,8-epoxycembra-1(15),2,11-trien-4-ol (3), and (7S*,8S*,15S*,1E,3E,1 1E)-7,8-epoxycembra-1,3,11-trien-15,16-diol (4), along with eleven known analogues 5-15.…”