Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum

Zhao, Min; Cheng, Shimiao; Yuan, Weiping; Xi, Yiyuan; Li, Xiubao; Jie, Dong; Huang, Kuang‐Hua; Gustafson, Kirk R.; Yan, Pengcheng

doi:10.3390/md14060111

Cited by 20 publications

(36 citation statements)

References 44 publications

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“…615 The latter study also led to a revision of relative conguration of the previously reported cembranoid sinularectin 1084. Further examples of cembranoids or related metabolites included sinularcasbanes M-O 1085-1087 (Sinularia polydactyla), 616 where the absolute conguration of 1086 was secured by X-ray crystallography, anti-inammatory uprolides N-P 1088-1090 (Eunicea succinea), 617 cubitanoids (a scaffold previously speculated as being photochemically-derived from cembranoids) nanoculones A 1091 and B 1092 and cembranoids nanolobols A-C 1093-1095 (Sinularia nanolobata), 618 locrassumins A-G 1095-1102, (À)-laevigatol B 1103, (À)-isosarcophine 1104 and sarcophytoxide analogue 1105 (Lobophytum crassum), 619 casbane-type diterpenoid 1106 and diepoxycembranes 1107 and 1108 (Lobophytum sp. ), 620 and pambanolides A-C 1109-1112 and a seco-sinulochmodin analogue 1113 (Sinularia inelegans).…”

Section: Cnidariansmentioning

confidence: 99%

Marine natural products

et al. 2018

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Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.

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Section: Cnidariansmentioning

confidence: 99%

Marine natural products

et al. 2018

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“…The presence of the COSY but not NOESY correlations between H-1 and H-2 indicated a trans -fused lactone with α -oriented H-2, which was also supported by the proton vicinal coupling constant of H-1/H-2 ( J = 4.5 Hz) [88]. In this type of cembranoid, the E -form C=C double bond systems are usually found at C-3/C-4 and C-7/C-8 and sometimes at C-11/C-12 [23]. The missing NOESY correlations between H-20/H-11, H-19/H-7, and H-18/H-3 implied an E -configuration for these three C=C double bonds [84].…”

Section: Resultsmentioning

confidence: 92%

“…Further investigation of this genus revealed more than 250 compounds categorized into cembrane-type diterpenoids [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58], other types of diterpenoids [59,60,61,62,63,64,65], lipids […”

Section: Introductionmentioning

confidence: 99%

“…Their effect was evaluated on iNOS (inducible nitric oxide synthase) [10,13], COX-2 (cyclooxygenase-2) [10,19], NF- κ B (nuclear factor kappa-light-chain-enhancer of activated B cells) [19,20], and neutrophil elastase release [15,18], as well as superoxide anion [15] and NO reduction [12,23]. Additionally, these compounds showed potent antiviral [31,49] and anti-bacterial activities [40,43], as well as brine shrimp [45] and fish toxicity [45].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum

et al. 2017

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Cembrane-type diterpenoids are among the most frequently encountered natural products from the soft corals of the genus Lobophytum. In the course of our investigation to identify anti-inflammatory constituents from a wild-type soft coral Lobophytum crassum, two new cembranoids, lobophyolide A (1) and B (2), along with five known compounds (3–7), were isolated. The structures of these natural products were identified using NMR and MS spectroscopic analyses. Compound 1 was found to possess the first identified α-epoxylactone group among all cembrane-type diterpenoids. The in vitro anti-inflammatory effect of compounds 1–5 was evaluated. The results showed that compounds 1–5 not only reduced IL-12 release, but also attenuated NO production in LPS-activated dendritic cells. Our data indicated that the isolated series of cembrane-type diterpenoids demonstrated interesting structural features and anti-inflammatory activity which could be further developed into therapeutic entities.

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“…Cembrane-type diterpenoids can be found in terrestrial and marine organisms, e.g. soft corals [73,74] and plants [75,76].…”

Section: Cembranolidesmentioning

confidence: 99%

Natural Cytotoxic Diterpenoids, a Potential Source of Drug Leads for Melanoma Therapy

Prieto

Silveira

2019

CPD

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Diterpenes present complex structure and due to their unique carbon skeleton and interesting biological activities, have been the focus of continuous studies for the development of new anticancer agents. Phorbol esters have been known for their activity against skin malignancies since ancient times. Taxol was first studied in melanoma cells, and recently ingenol mebutate has been approved for the chemoprevention of melanoma in actinic keratosis patients. Therefore, there is scope for research on this class of compounds. We here aim to review the relevant original research reporting on isolated diterpenes with cytotoxic and/or antitumoral activities upon melanoma cells. By collating and discussing the implications of past and current developments on diterpenes, we hope to steer further interest on this field and facilitate the drug discovery activities of the scientific community towards finding potential alternatives to current melanoma chemotherapy.

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Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum

Cited by 20 publications

References 44 publications

Marine natural products

Marine natural products

Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum

Natural Cytotoxic Diterpenoids, a Potential Source of Drug Leads for Melanoma Therapy

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