Celsior Versus University of Wisconsin Preserving Solutions for Liver Transplantation: Postreperfusion Syndrome and Outcome of a 5‐Year Prospective Randomized Controlled Study

García-Gil, Francisco A.; Serrano, M.T.; Fuentes-Broto, Lorena; Arenas, Juan; Garcia, J.; Güemes, Antonio; Bernal, Vanesa; Campillo, Ana; Sostres, Carlos; Araiz, Juan J.; Royo, Pablo; Simón, Miguel Ángel

doi:10.1007/s00268-011-1078-7

Cited by 29 publications

(24 citation statements)

References 69 publications

(80 reference statements)

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“…The findings indicate that Celsior has comparable efficacy and safety to University of Wisconsin solution for liver graft preservation within a median ischemia time of 7 h. These results verified an earlier pilot, randomized prospective trial suggesting that University of Wisconsin and Celsior have comparable efficacy [56]. A recent 5-year prospective RCT demonstrated similar safety and effectiveness between University of Wisconsin (n ¼ 51) and Celsior solution (n ¼ 51) [17]. A recent 5-year prospective RCT demonstrated similar safety and effectiveness between University of Wisconsin (n ¼ 51) and Celsior solution (n ¼ 51) [17].…”

Section: Liversupporting

confidence: 70%

“…Also, a prospective, nonrandomized, multicenter, European registry study suggested Celsior and University of Wisconsin solutions provided similar liver allograft survival [57]. Importantly, this study also detected a reduction in postreperfusion syndrome in the livers stored with Celsior versus University of Wisconsin solution [17]. Importantly, this study also detected a reduction in postreperfusion syndrome in the livers stored with Celsior versus University of Wisconsin solution [17].…”

Section: Liversupporting

confidence: 56%

“…Histidine serves as a buffer, tryptophan is a membrane stabilizer, and ketoglutarate is an energy substrate (see Table 2) [9][10][11][12][13][14][15][16][17][18][19]. HTK, which was originally designed as a cardioplegia, is a crystalloid with osmolarity slightly higher than the intracellular space.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preservation solutions for static cold storage of abdominal allografts

Parsons

Guarrera

2014

Current Opinion in Organ Transplantation

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Section: Liversupporting

confidence: 70%

Section: Liversupporting

confidence: 56%

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Preservation solutions for static cold storage of abdominal allografts

Parsons

Guarrera

2014

Current Opinion in Organ Transplantation

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“…The current accepted interpretation of this phenomenon is the 'second strike theory'. A large number of alcohol intake induces the formation of alcoholic fatty liver as a 'first strike', and the alcoholic liver injury requires a second strike, including the change in nutrition, the effect of drug poisons, viral infections and genetic factors (19). The result showed that Quercetin significantly reduced AST, ALT, TBIL and TG content in ALD mice.…”

Section: Discussionmentioning

confidence: 97%

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

2017

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Abstract. Quercetin is a type of flavonoid compound, which has potent antioxidant and anti-inflammatory activities, capable of treating a variety of diseases including neurodegenerative diseases, tumors, diabetes and obesity. The present study selected alcohol-induced liver injury model mice and aimed at studying the protective role of quercetin in preventing alcohol-induced liver injury. In alcohol-induced liver injury mice treated with quercetin, it was demonstrated that levels of aspartate transaminase, alanine transaminase, total bilirubin and triglyceride were reduced. In addition to this, the activities of the antioxidant enzymes superoxide dismutase and glutathione peroxidase were increased, malondialdehyde was inhibited, and interleukin (IL)-1β, IL-6, IL-10 and inducible nitric oxide synthase were suppressed. Quercetin additionally suppressed the protein expression levels of B-cell lymphoma (Bcl)-2, Bcl-2 associated X apoptosis regulator, Caspase-3, poly ADP-ribose polymerase, and signal transducer and activator of transcription (STAT) 3 phosphorylation, nuclear factor (NF)-κB and protein kinase B (Akt) phosphorylation levels in alcohol-induced liver injured mice. These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-κB and STAT3 pathway.

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“…Compared with Celsior preservation solution, UW is associated with less ischemic necrosis in early cardiac allograft biopsies [89] and improved short-term outcomes [90]. UW was superior to histidine-tryptophan-ketoglutarate (HTK) solution after prolonged cold preservation of renal grafts [91] but inferior to Celsior in liver transplantation associated with more post-reperfusion syndrome [92]. Adenosinelidocaine preservation solution supplemented with melatonin and insulin improved cardiac output, heart rate, and blood pressure following cold storage of rat hearts for 8 h. Adenosine-lidocaine alone was more efficacious than Custodial HTK and Celsior preservation solutions [93].…”

Section: Clinical Applicationmentioning

confidence: 99%

The CD39-adenosinergic axis in the pathogenesis of renal ischemia–reperfusion injury

Roberts

Lü

Rajakumar

et al. 2012

Purinergic Signalling

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Hypoxic injury occurs when the blood supply to an organ is interrupted; subsequent reperfusion halts ongoing ischemic damage but paradoxically leads to further inflammation. Together this is termed ischemia-reperfusion injury (IRI). IRI is inherent to organ transplantation and impacts both the short-and long-term outcomes of the transplanted organ. Activation of the purinergic signalling pathway is intrinsic to the pathogenesis of, and endogenous response to IRI. Therapies targeting the purinergic pathway in IRI are an attractive avenue for the improvement of transplant outcomes and the basis of ongoing research. This review aims to examine the role of adenosine receptor signalling and the ecto-nucleotidases, CD39 and CD73, in IRI, with a particular focus on renal IRI. Ischemia-reperfusion injury (IRI) is an obligatory insult in transplantation occurring at the time of organ procurement and engraftment. Ischemia is induced when blood flow to an organ is interrupted. Re-establishment of blood flow is essential to prevent ongoing hypoxic injury but paradoxically imparts further injury, termed IRI. Warm ischemia is relatively short in brain dead donors (<30 min); however, this can be prolonged in donors following cardiac arrest (up to 90 min). Furthermore, unique to transplantation is the period of cold preservation, which slows the cellular metabolic rate in order to minimize ongoing ischemic damage but which may be prolonged (extending to hours). The clinical ramifications of IRI include systemic inflammatory effects and organ dysfunction, increasing graft immunogenicity, the risk of delayed graft function, acute rejection, and chronic allograft dysfunction. There is substantial evidence implicating purinergic signalling in both the pathogenesis of and the endogenous response to IRI, and strategies targeting various aspects of the pathway may therefore be of therapeutic potential. ATP, present in relatively high concentrations intracellularly, is extruded from injured and necrotic cells into the extracellular space or released in a more controlled manner from apoptotic cells through pannexin hemi-channels and from inflammatory cells via connexin hemi-channels [1]. Upon release, extracellular ATP acts in an autocrine or paracrine manner on specific cell-surface P2 receptors belonging to two subclasses, the G protein-coupled P2Y receptors and the ATP-gated P2X nonselective cation channels [2]. ATP Keywords

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Celsior Versus University of Wisconsin Preserving Solutions for Liver Transplantation: Postreperfusion Syndrome and Outcome of a 5‐Year Prospective Randomized Controlled Study

Abstract: While retaining the same degree of safety and effectiveness as UW for LT, CS may yield postliver graft reperfusion benefits, as shown in this study by a significant reduction in the incidence of PRS and greater metabolic control.

Cited by 29 publications

References 69 publications

Preservation solutions for static cold storage of abdominal allografts

Preservation solutions for static cold storage of abdominal allografts

Quercetin prevents alcohol‑induced liver injury through targeting of PI3K/Akt/nuclear factor‑κB and STAT3 signaling pathway

The CD39-adenosinergic axis in the pathogenesis of renal ischemia–reperfusion injury

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