Cellulose-graft-poly(<scp>l</scp>-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs

Dai, Lin; Yang, Tingyuan; He, Jing; Deng, Lihong; Liu, Jing; Wang, Luying; Lei, Jiandu; Wang, Lianyan

doi:10.1039/c4tb00956h

Cited by 71 publications

(61 citation statements)

References 39 publications

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“…Furthermore, the uptake of CE‐g–PMMA–BA NPs enhanced the area under curve (AUC) by 3.1‐fold compared with native BA. In another study, BA‐loaded cellulose‐graft poly( l ‐lactic acid) NPs (CE‐g–PLLA–BA NPs) were developed in order to improve efficacy . In vitro cytotoxicity studies in human lung carcinoma (A549) and LLC cell lines demonstrated superior cytotoxicity of CE‐g–PLLA–BA NPs compared with native BA.…”

Section: Nanoformulations For Betulinic Acid Deliverymentioning

confidence: 99%

Therapeutic applications of betulinic acid nanoformulations

Saneja

Arora

Kumar

et al. 2018

Annals of the New York Academy of Sciences

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Betulinic acid (BA), a naturally occurring plant-derived pentacyclic triterpenoid, has gained attention in recent years owing to its broad-spectrum biological and medicinal properties. Despite the pharmacological activity of BA, it has been associated with some drawbacks, such as poor aqueous solubility and short half-life in vivo, which limit therapeutic application. To solve these problems, much work in recent years has focused on enhancing BA's aqueous solubility, half-life, and efficacy by using nanoscale drug delivery systems. Several different kinds of nanoscale delivery systems-including polymeric nanoparticles, magnetic nanoparticles, liposomes, polymeric conjugates, nanoemulsions, cyclodextrin complexes, and carbon nanotubes-have been developed for the delivery of BA. Here, we focus on the recent developments of novel nanoformulations used to deliver BA in order to improve its efficacy.

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Section: Nanoformulations For Betulinic Acid Deliverymentioning

confidence: 99%

Therapeutic applications of betulinic acid nanoformulations

Saneja

Arora

Kumar

et al. 2018

Annals of the New York Academy of Sciences

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“…21,22 It has been demonstrated that IgE antibody plays an important role in mediating type Ⅰ hypersensitivity reaction. Some natural anti-cancer drugs such as docetaxel, paclitaxel, and teniposide cyclosporine were usually associated with a high incidence of the type Ⅰ hypersensitivity reaction.…”

Section: Side Effortmentioning

confidence: 99%

“…23 The DLE of the drug-loaded nanoparticles were listed in Table. 1. In this study, the amphiphilic conjugate mPEG-DGN self-assembled into nanoparticles in aqueous phase for loading HCPT (Scheme.…”

Section: Characterization Of the Nanoparticlesmentioning

confidence: 99%

A self-assembled nanoparticle platform based on poly(ethylene glycol)–diosgenin conjugates for co-delivery of anticancer drugs

Dai

Liu

et al. 2015

RSC Adv.

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Diosgenin (DGN) is a steroidal saponin from a therapeutic herb. It is reported to be a kind of potential natural antitumor drugs. However, clinical application of diosgenin in cancer therapy is limited due to undesirable pharmaceutical characteristics such as its consequently poor solubility and low bioavailability. Here we developed a nanoparticle platform based on poly(ethylene glycol)-diosgenin (mPEG-DGN) conjugates for co-delivery of anticancer drug. Firstly, to improve solubility and bioavailablity of DGN, the amphiphilic conjugates mPEG-DGN were made by linking DGN with mPEG. Then they self-assembled stable nanoparticles to deliver another anticancer drug hydroxycamptothecin (HCPT) by a simple nanoprecipitation method. The obtained nanoparticles possessed appropriate size, high drug loading efficiency of diosgenin and HCPT, slowly release drugs and high synergistic effects. Hence, the mPEG-DGN nanoparticle is a promising drug delivery system for cancer therapy.Scheme. 1 Synthesis of mPEG-DGN (A). Illustration of mPEG-DGN codelivery of HCPT (B).

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“…However, a large proportion of those electrochemical reactions require the noble-metal based catalysts, which are expensive and rare in the earth, that limited the industry application of those new energy system. [21][22][23][24][25] Therefore, there are still critical challenges in the fabrication of alternative electrocatalysts with high performance based on non-noble metal materials.…”

Section: Introductionmentioning

confidence: 99%

Transition Metal (Fe, Co and Ni)−Carbide−Nitride (M−C−N) Nanocatalysts: Structure and Electrocatalytic Applications

et al. 2019

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Transition metal−carbon−nitrogen (M−C−N) nanocrystals, such as hybrid‐structure, heterostructure, and cluster or single metal atoms anchored on carbon−nitrogen skeleton, have attracted wide attention in various fields for their superior physicochemical properties. However, it remains a great challenge to synthesize those M−C−N nanocrystals on a large nanoscale for their intrinsic characteristics, which further limited their extensive application in different fields. In this minireview, we present an overview of those M−C−N nanostructures in terms of their synthetic methods, applications and relationship between structure and properties. In addition, this review will also provide some perspectives on the challenges and opportunities of those nanomaterials.

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Cellulose-graft-poly(l-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs

Abstract: BA-loaded cellulose-graft-poly(l-lactic acid) nanoparticles were fabricated by employing cellulose and poly(l-lactic acid) as materials and betulinic acid as a model drug. The nanoparticles have appropriate size and excellent antitumor activities.

Cited by 71 publications

References 39 publications

Therapeutic applications of betulinic acid nanoformulations

Therapeutic applications of betulinic acid nanoformulations

A self-assembled nanoparticle platform based on poly(ethylene glycol)–diosgenin conjugates for co-delivery of anticancer drugs

Transition Metal (Fe, Co and Ni)−Carbide−Nitride (M−C−N) Nanocatalysts: Structure and Electrocatalytic Applications

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