Cellulose Acetate Impressions of the Ocular Surface

Nelson, J. Daniel; Havener, Virginia R.; Cameron, J. Douglas

doi:10.1001/archopht.1983.01040020871007

Cited by 288 publications

(192 citation statements)

References 14 publications

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“…Various grading schemes were used, most of them being derived from the schemes proposed by Nelson et al, 3 Nelson, 4 or Tseng. 5 Grading schemes provide a quick means of gross assessment of the morphological appearance of the ocular surface, especially the bulbar conjunctiva and are therefore useful for diagnosis and follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…As performed by Aragona et al, 15 but different to the protocols of Nelson et al, 3 Nelson, 4 and Tseng, 5 these parameters were judged individually resulting in the so-called IC subscores and summarized to the IC score. This provides the possibility to evaluate each morphological parameter separately, and to inter-relate each result, IC score or IC subscores, with diagnostic or clinical parameters as well.…”

Section: Discussionmentioning

confidence: 99%

“…Pathological changes, such as squamous metaplasia of the epithelial cells, keratinization, and reduction of goblet cell density up to total goblet cell loss, occur in numerous disorders such as dry eye, Sjö gren's syndrome, blepharokonjunctivitis, inflammatory keratokonjunctivitis, and vitamin A deficiency. [3][4][5][6][7][8][9][10][11][12] For staging of the morphological changes of the conjunctiva, several grading systems have been developed. The first grading system published by Nelson et al 3 was based on the morphological appearance of the conjunctival epithelial and goblet cells, which was completed in 1988 4 by the so-called mean individual epithelial cell area, according to the degree of squamous metaplasia, and the number of goblet cells.…”

Section: Introductionmentioning

confidence: 99%

“…Heiligenhaus et al 14 added one morphological parameter to the staging of Tseng, the condensation of the nuclear chromatin. In the abovementioned grading schemes, [3][4][5]13,14 the alteration of the epithelial cells and nuclei, goblet cell density, and morphological changes of goblet cells, as well as other morphological qualities were judged conjointly.…”

Section: Introductionmentioning

confidence: 99%

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Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome

Schwantzer

Berghold

et al. 2005

Eye

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Purpose To evaluate the IC score, a newly developed grading system for the morphological alterations of the ocular surface as a diagnostic tool in relation to type and severity of dry eye disease. Methods Impression cytological specimens of 309 patients with simple dry eye (S-DE), 50 patients with Sjö gren's syndrome and dry eye (SS-DE), and 39 patients with connective tissue disease and dry eye (CTD-DE) were examined. In all, 10 different morphological parameters were judged with points (IC subscores) and summarized to the IC score. IC score and subscores were correlated to tear function test results and with each other. Results SS-DE patients had the highest IC scores and IC subscores. IC scores and IC subscores correlated significantly with the fluorescein staining of the cornea in all three patient groups. They were correlated to the rose bengal score in SS-DE and S-DE patients. The analysis of the IC subscores showed that there are significant correlations between most of the morphological alterations investigated. This underlines the importance of each parameter for the summarized IC score. Conclusion The IC score provides detailed information about the morphological alterations of the bulbar conjunctiva. It has proven to be useful for the differentiation of dry eye diseases and might help in the investigation of the pathogenesis of these diseases as well as for follow-up and therapy control.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome

Schwantzer

Berghold

et al. 2005

Eye

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“…Transparent filters were examined using light microscopy at a magnification of ¿250 and ¿100. The degree of infection, inflammation and keratinization, the presence of the snake-like phenomenon (Marner 1980) and the status of the goblet cells (Nelson et al 1983) were graded on a scale from 0-3 (for snake-like phenomenon on a scale of 0-2).…”

Section: Tear Secretion and Ocular Surfacementioning

confidence: 99%

Short‐term effect of latanoprost and timolol eye drops on tear fluid and the ocular surface in patients with primary open‐angle glaucoma and ocular hypertension

Thygesen

Aaen

Theodorsen

et al. 2000

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To investigate and compare the short term effects of topical latanoprost and timolol on the tear fluid and ocular surface condition in patients with bilateral primary open angle glaucoma or ocular hypertension. Methods: Thirty-seven patients were included in this randomized, doublemasked, parallel group study. Patients received either latanoprost 0.005% (nΩ 18) or timolol 0.5% (nΩ19) instilled once daily in the morning for a treatment period of 27 days. Routine ophthalmic examinations, including intraocular pressure measurement, as well as tests to evaluate tear fluid and the ocular surface were performed. Results: After one drop of medication, tear secretion was significantly reduced by timolol, but not by latanoprost. At the end of the study the break-up time (BUT) was significantly decreased in the timolol group but not in the latanoprost group. The BUT still remained in the normal range in both groups, although it is important to note that timolol was administered at half the clinical dose. Both latanoprost and timolol tended to increase Rose-Bengal staining of the cornea and conjunctiva after one month of treatment but no statistically significant difference was found between the groups. Corneal sensitivity was within the normal range for all patients during the study. Conclusion: Regarding ocular surface effects, no clinically important differences between latanoprost and timolol were observed as all the effects remained in the normal range.

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