Cellulitis on face in a patient with congenital afibrinogenemia

Chandan, G B; Annaji, AG; Bhatnagar, Shruti; Mohandas, U; Dave, Paresh

doi:10.4103/0970-4388.79933

Cited by 2 publications

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“…The treatment of accessible bleeding points in afibrinogenemia patients is with the local application of pressure, vasoconstrictor drugs and, if necessary, sutures. Drugs that are commonly used include vitamin K, protamine sulfate and calcium gluconate, and anti‐fibrinolytic agents, for example, ɛ amino‐caproic acid and the kallikrein inhibitor, trasylol, heparin, desamino‐8‐d‐arginine vasopressin, androgens and topical hemostats such as thrombin 8–10 …”

Section: Discussionmentioning

confidence: 99%

Diagnosis and non‐surgical periodontal management in congenital afibrinogenemia: report of a rare case

Gadagi

Chava

2012

J of Invest & Clin Dent

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Medical records have an important role in the diagnosis and planning treatment modalities of periodontal diseases. Surgical periodontal procedures can pose severe complications if the underlying systemic condition is not recorded. To substantiate this, we present a rare case of afibrinogenemia that was reported to the Department of Periodontics, Narayana Dental College, Nellore, India. The present case report gives details of fibrinogen disorder and the dental management of such cases.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and non‐surgical periodontal management in congenital afibrinogenemia: report of a rare case

Gadagi

Chava

2012

J of Invest & Clin Dent

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“…CFD is a bleeding disorder with a prevalence rate of ∼8% among the rare bleeding disorders with an estimated prevalence of 1 in a million [1][2][3]. Prevalence data from India are sparse with only a few case reports [6][7][8][9][10][11][12][13][14][15][16]. Sumitha et al [17] described the molecular basis of CFD in 27 patients, and Shetty et al [18] reported fibrinogen deficiencies in 12.1% of the 321 rare clotting factor deficiency cohort.…”

Section: Congenital Fibrinogen Deficiencymentioning

confidence: 99%

Congenital Fibrinogen Deficiency in India and Role of Human Fibrinogen Concentrate

et al. 2021

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Congenital fibrinogen deficiency is an inherited disorder due to genetic mutations with diverse presentations arising from reduced fibrinogen levels (hypofibrinogenemia), absence of fibrinogen in circulation (afibrinogenemia), abnormal functioning (dysfibrinogenemia) or both reduced levels and abnormal functioning (hypodysfibrinogenemia) of fibrinogen. The decreased fibrinogen concentration in congenital fibrinogen deficiency necessitates fibrinogen replacement therapy with fresh frozen plasma, cryoprecipitate, or human fibrinogen concentrate. However, the use of fresh frozen plasma and cryoprecipitate is limited owing to their longer transfusion time, requirement of high doses, volume overload, risk of viral transmission, and other safety concerns. The availability of human fibrinogen concentrate has made it the preferred replacement alternative due to its reduced risk of viral transmission, smaller infusion volume, and accurate dosing. The hemostatic efficacy and safety of human fibrinogen concentrate in congenital fibrinogen deficiency is well established in the literature. We review the prevalence of congenital fibrinogen deficiency in India and the current role of human fibrinogen concentrate in its management.

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Cellulitis on face in a patient with congenital afibrinogenemia

Abstract: Congenital afibrinogenemia is a rare coagulation disorder, with an estimated prevalence of 1 : 1,000,000, characterized by a complete absence to reduced level of circulating fibrinogen. This article presents a case of congenital afibrinogenemia, which presented as cellulitis on the face.

Cited by 2 publications

References 1 publication

Diagnosis and non‐surgical periodontal management in congenital afibrinogenemia: report of a rare case

Diagnosis and non‐surgical periodontal management in congenital afibrinogenemia: report of a rare case

Congenital Fibrinogen Deficiency in India and Role of Human Fibrinogen Concentrate

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