Cellulitis and Bacteraemia due to Chryseobacterium indologenes

Green, B.T.; Nolan, Patrick E.

doi:10.1053/jinf.2001.0822

Cited by 38 publications

(27 citation statements)

References 8 publications

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“…Although their overall clinical impact is lower than that of Enterobacteriaceae, Pseudomonas, or Acinetobacter species, Flavobacteriaceae may cause various clinical syndromes that are not always straightforward to treat, due mainly to their intrinsic resistance to several antimicrobial agents (29). Eight different sublineages of resident enzymes in members of the family Flavobacteriaceae have been identified thus far (4-7, 18, 20, 26), and most of them (BlaB from Elizabethkingia meningoseptica, IND from Chryseobacterium indologenes, JOHN from Flavobacterium johnsoniae, CGB from Chryseobacterium gleum, EBR from Empedobacter brevis, TUS from Myroides odoratus, and MUS from Myroides odoratimimus) belong to subclass B1, although the GOB enzymes (from E. meningoseptica) belong to subclass B3.The most common flavobacterium from clinical specimens is C. indologenes, which is associated with different types of infections, such as intra-abdominal and urinary tract infections, catheter-related bacteremia, cellulitis, sepsis, and pneumonia, likely promoted by the bacterium's ability to form biofilm and to produce proteases (1,3,15,16,21,23,24,33). In some nosocomial settings, C. indologenes infections were also associated with relatively high mortality rates (16).…”

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“…The most common flavobacterium from clinical specimens is C. indologenes, which is associated with different types of infections, such as intra-abdominal and urinary tract infections, catheter-related bacteremia, cellulitis, sepsis, and pneumonia, likely promoted by the bacterium's ability to form biofilm and to produce proteases (1,3,15,16,21,23,24,33). In some nosocomial settings, C. indologenes infections were also associated with relatively high mortality rates (16).…”

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IND-6, a Highly Divergent IND-Type Metallo-β-Lactamase fromChryseobacterium indologenesStrain 597 Isolated in Burkina Faso

Zeba

Luca

Dubus

et al. 2009

Antimicrob Agents Chemother

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The genus Chryseobacterium and other genera belonging to the family Flavobacteriaceae include organisms that can behave as human pathogens and are known to cause different kinds of infections. Several species of Flavobacteriaceae, including Chryseobacterium indologenes, are naturally resistant to ␤-lactam antibiotics (including carbapenems), due to the production of a resident metallo-␤-lactamase. Although C. indologenes presently constitutes a limited clinical threat, the incidence of infections caused by this organism is increasing in some settings, where isolates that exhibit multidrug resistance phenotypes (including resistance to aminoglycosides and quinolones) have been detected. Here, we report the identification and characterization of a new IND-type variant from a C. indologenes isolate from Burkina Faso that is resistant to ␤-lactams and aminoglycosides Metallo-␤-lactamases (MBLs) belong to Ambler's class B, and their activity requires at least one zinc ion in the active site. These enzymes are particularly worrisome resistance determinants due to their ability to hydrolyze most ␤-lactam compounds, including carbapenems, while they are not susceptible to conventional ␤-lactamase inhibitors (e.g., clavulanic acid, sulbactam, and tazobactam) (25). Besides the acquired MBL genes which currently disseminate in major human pathogens (e.g., Pseudomonas aeruginosa) by means of mobile genetic elements (plasmids, integrons, or ISCR elements), most MBL genes identified thus far have been found in the chromosomes of various bacterial species, including nonpathogenic organisms (such as Caulobacter crescentus), plant pathogens (Erwinia carotovora), and occasional human pathogens such as Stenotrophomonas maltophilia, Aeromonas spp., and members of the family Flavobacteriaceae (25, 32). The latter family includes several species in which the production of a resident MBL has been detected. Although their overall clinical impact is lower than that of Enterobacteriaceae, Pseudomonas, or Acinetobacter species, Flavobacteriaceae may cause various clinical syndromes that are not always straightforward to treat, due mainly to their intrinsic resistance to several antimicrobial agents (29). Eight different sublineages of resident enzymes in members of the family Flavobacteriaceae have been identified thus far (4-7, 18, 20, 26), and most of them (BlaB from Elizabethkingia meningoseptica, IND from Chryseobacterium indologenes, JOHN from Flavobacterium johnsoniae, CGB from Chryseobacterium gleum, EBR from Empedobacter brevis, TUS from Myroides odoratus, and MUS from Myroides odoratimimus) belong to subclass B1, although the GOB enzymes (from E. meningoseptica) belong to subclass B3.The most common flavobacterium from clinical specimens is C. indologenes, which is associated with different types of infections, such as intra-abdominal and urinary tract infections, catheter-related bacteremia, cellulitis, sepsis, and pneumonia, likely promoted by the bacterium's ability to form biofilm and to produce proteases (1,3,15,16,21,23,24...

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confidence: 99%

mentioning

confidence: 99%

IND-6, a Highly Divergent IND-Type Metallo-β-Lactamase fromChryseobacterium indologenesStrain 597 Isolated in Burkina Faso

Zeba

Luca

Dubus

et al. 2009

Antimicrob Agents Chemother

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“…C indologenes has been reported to cause primary bacteraemia,9 13 catheter-related bacteraemia,7 10 11 15 wound sepsis,13 16 cellulitis,17 pyelonephritis,13 peritonitis,13 biliary tract infection,13 urinary tract infection,18 pneumonia13 14 and keratitis of the eye 19. Infections caused by all Chryseobacterium species combined represent only 0.03% of all bacterial isolates collected by the SENTRY Program during the 5-year period evaluated (1997–2001) with about 40% due to C indologenes 20.…”

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confidence: 99%

Chryseobacterium indologenesperitonitis in peritoneal dialysis

Afshar

Nobakht

Lew³

2013

BMJ Case Reports

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Peritoneal dialysis-related peritonitis remains a major complication of peritoneal dialysis in patients with end-stage renal disease. Chryseobacterium indologenes is a rare organism that has been reported to cause infections mostly in hospitalised patients with severe underlying diseases. We report the first case of C indologenes peritonitis in a patient on peritoneal dialysis outside of Asia. Our patient with end-stage renal disease on peritoneal dialysis grew C indologenes from peritoneal fluid when he presented with abdominal pain and cloudy effluent. The patient responded well to intraperitoneal antibiotic therapy. Tenckhoff catheter did not require removal. This case demonstrates the importance of considering rare causes of peritonitis, such as C indologenes, in patients on peritoneal dialysis. Given the resistance of such organisms to commonly used broad-spectrum antibiotics, antimicrobial susceptibility testing must be assessed as early as possible to assure appropriate antibiotic coverage to avoid untreated peritonitis leading to peritoneal dialysis failure.

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“…indologenes, formerly known as Flavobacterium CDC group IIb, is rarely isolated from clinical specimens and may cause primary bacteremia, catheter-related bacteremia, wound sepsis, cellulitis, pyonephrosis, peritonitis, biliary tract infection and ventilator-associated pneumonia [3][4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Recurrent Port Infection Due to Chryseobacterium Indologenes

Mutcali

Yemişen

Soylu

et al. 2013

EAJM

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Infections due to Chryseobacterium indologenes (C. indologenes) are rare and generally associated with immunosupression and indwelling catheters. We report a recurrent port infection caused by C. indologenes. In the first bacteremia episode we did not remove the port and only applied antibiotherapy. However, the patient presented with bacteremia with the same bacteria and successfully treated with antibiotherapy and removal of the port. Key Words: Chryseobacterium indologenes, Port infection ÖzetChryseobacterium indologenes ile enfeksiyon gelişimi nadirdir ve genellikle immün baskılanma ve kalıcı kateterler ile ilişkilidir. Bu yazı-mızda C. indologenes'e bağlı gelişen port enfeksiyonu sunmaktayız. İlk bakteremi atağında port çıkarılmadı ve sadece antibiyotik tedavisi verildi. Ancak, hasta aynı mikroorganizma ile yeni bir bakteremi atağı geçirdi ve portun çıkarılması ve uygun antibiyoterapi ile başarılı bir şekilde tedavi edildi.

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Cellulitis and Bacteraemia due to Chryseobacterium indologenes

Cited by 38 publications

References 8 publications

IND-6, a Highly Divergent IND-Type Metallo-β-Lactamase fromChryseobacterium indologenesStrain 597 Isolated in Burkina Faso

IND-6, a Highly Divergent IND-Type Metallo-β-Lactamase fromChryseobacterium indologenesStrain 597 Isolated in Burkina Faso

Chryseobacterium indologenesperitonitis in peritoneal dialysis

Recurrent Port Infection Due to Chryseobacterium Indologenes

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