2013
DOI: 10.1371/journal.pone.0054494
|View full text |Cite
|
Sign up to set email alerts
|

Cellular Mechanism Underlying Formaldehyde-Stimulated Cl− Secretion in Rat Airway Epithelium

Abstract: BackgroundRecent studies suggest that formaldehyde (FA) could be synthesized endogeneously and transient receptor potential (TRP) channel might be the sensor of FA. However, the physiological significance is still unclear.Methodology/Principal FindingsThe present study investigated the FA induced epithelial Cl- secretion by activation of TRPV-1 channel located in the nerve ending fiber. Exogenously applied FA induced an increase of I SC in intact rat trachea tissue but not in the primary cultured epithelial ce… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
2
0

Year Published

2015
2015
2021
2021

Publication Types

Select...
2
1

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(3 citation statements)
references
References 37 publications
1
2
0
Order By: Relevance
“…The time course of decrease is same as that at the declining phase of Cl − secretion following a transient increase, although shows no instantaneous change just after a change in G A (see Figures 3B,C ). A similar phenomenon is observed in Cl − secretion in cells treated with formaldehyde, bile acids, or Pasteurella multocida toxin (Hennig et al, 2008 ; Ao et al, 2013 ; Luo et al, 2013 ), suggesting that formaldehyde, bile acids, or Pasteurella multocida toxin would activate the apical and basolateral Cl − channels in the same level .…”
Section: Resultssupporting
confidence: 52%
See 1 more Smart Citation
“…The time course of decrease is same as that at the declining phase of Cl − secretion following a transient increase, although shows no instantaneous change just after a change in G A (see Figures 3B,C ). A similar phenomenon is observed in Cl − secretion in cells treated with formaldehyde, bile acids, or Pasteurella multocida toxin (Hennig et al, 2008 ; Ao et al, 2013 ; Luo et al, 2013 ), suggesting that formaldehyde, bile acids, or Pasteurella multocida toxin would activate the apical and basolateral Cl − channels in the same level .…”
Section: Resultssupporting
confidence: 52%
“…Many compounds show various time-dependent patterns in stimulation of transcellular Cl − secretion in epithelial cells (Niisato et al, 1999 ; Hennig et al, 2008 ; Ao et al, 2013 ; Luo et al, 2013 ). Transcellular Cl − secretion in epithelial cells is mediated by uptake and release of Cl − into and from the intracellular space.…”
Section: Resultsmentioning
confidence: 99%
“…Rat tracheal epithelial cells were cultured with a modified procedure, as previously described (22). In brief, the tracheas were isolated and bathed in Hank's balanced salt solution.…”
Section: Primary Culture Of Rat Tracheal Epithelial Cellsmentioning
confidence: 99%