TRPs in Respiratory Disorders

Zholos, Alexander; McGarvey, Lorcan; Ennis, Madeleine

doi:10.1016/b978-0-12-420024-1.00026-6

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Trpa1 In Inflammatory Pain1

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2019

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“…Several inflammatory compounds such as nitric oxide, protons, and ozone activated human TRPA1 heterologously through an oxidative mechanism [121,122], highlighting the importance of oxidative stress and TRPA1 in inflammatory conditions. Consistently, exposition to cigarette smoke may increment extracellular ROS, which activate TRPA1 inducing an increase of intracellular ROS and activation of pro-inflammatory signalling [123].…”

Section: Trpa1 In Inflammatory Painmentioning

confidence: 99%

Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?

Giorgi

Nikolaeva-Koleva

Alarcón-Alarcón

et al. 2019

IJMS

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Over the last decades, a great array of molecular mediators have been identified as potential targets for the treatment of chronic pain. Among these mediators, transient receptor potential (TRP) channel superfamily members have been thoroughly studied. Namely, the nonselective cationic channel, transient receptor potential ankyrin subtype 1 (TRPA1), has been described as a chemical nocisensor involved in noxious cold and mechanical sensation and as rivalling TRPV1, which traditionally has been considered as the most important TRP channel involved in nociceptive transduction. However, few TRPA1-related drugs have succeeded in clinical trials. In the present review, we attempt to discuss the latest data on the topic and future directions for pharmacological intervention.

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Section: Trpa1 In Inflammatory Painmentioning

confidence: 99%