Cellular mechanism of renin release

Schweda, Frank; Kurtz, Armin

doi:10.1111/j.1365-201x.2004.01309.x

Cited by 63 publications

(73 citation statements)

References 59 publications

(75 reference statements)

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“…34,35 T-type CCBs have a dual effect on plasma renin activity and renin messenger RNA expression in vivo, with low concentrations stimulating and high concentrations inhibiting the renin system. 36 However, in this study, plasma renin activity did not change significantly; therefore, the change in aldosterone may not have been due to the effect of renin but rather to a direct inhibition of aldosterone secretion. Furthermore, although serum Na and K levels were not changed after treatment with either CCB, urinary K/Cr and Na/K ratios were decreased in the benidipine group without any decrease in eGFR.…”

Section: Discussioncontrasting

confidence: 59%

Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria

et al. 2010

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Benidipine inhibits both L-and T-type Ca channels, and has been shown to dilate the efferent arterioles as effectively as the afferent arterioles. In this study, we conducted an open-label and randomized trial to compare the effects of benidipine with those of amlodipine on blood pressure (BP), albuminuria and aldosterone concentration in hypertensive patients with mild-tomoderate stage chronic kidney disease (CKD). Patients with BPX130/80 mm Hg, with estimated glomerular filtration rate (eGFR) of 30-90 ml min À1 per 1.73 m 2 , and with albuminuria430 mg per g creatinine (Cr), despite treatment with the maximum recommended dose of angiotensin II receptor blockers (ARBs) were randomly assigned to two groups. Patients received either of the following two treatment regimens: 2 mg per day benidipine, which was increased up to a dose of 8 mg per day (n¼52), or 2.5 mg per day amlodipine, which was increased up to a dose of 10 mg per day (n¼52). After 6 months of treatment, a significant and comparable reduction in the systolic and diastolic BP was observed in both groups. The decrease in the urinary albumin to Cr ratio in the benidipine group was significantly lower than that in the amlodipine group. Although plasma renin activity was not different in the two groups, plasma aldosterone levels were significantly decreased in the benidipine group. Moreover, urinary Na/K ratio was significantly decreased in the benidipine group but remained unchanged in the serum. It may be concluded that benidipine results in a greater reduction of plasma aldosterone and albuminuria than amlodipine, and that these effects are independent of BP reduction.

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Section: Discussioncontrasting

confidence: 59%

Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria

et al. 2010

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“…A recent report suggested that amlodipine increased the plasma renin concentration in patients with essential hypertension (30). However, a T-type calcium channel blocker had a dual effect on plasma renin activity and renin messenger RNA expression in vivo, with the low concentration stimulating and the high concentration inhibiting the renin system (31). Since the inhibitory effect of T-type calcium channel blockers is apparent in conscious rats in vivo but not in vitro, the effect of T-type calcium channel blockers on PARC in comparison with amlodipine remains controversial (28,31).…”

Section: Discussionmentioning

confidence: 99%

“…However, a T-type calcium channel blocker had a dual effect on plasma renin activity and renin messenger RNA expression in vivo, with the low concentration stimulating and the high concentration inhibiting the renin system (31). Since the inhibitory effect of T-type calcium channel blockers is apparent in conscious rats in vivo but not in vitro, the effect of T-type calcium channel blockers on PARC in comparison with amlodipine remains controversial (28,31). In the present study, PARC did not change significantly; therefore, the change in ALD may not have been due to the effect of renin but rather to a direct inhibition of ALD secretion.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effects of Efonidipine and Amlodipine on Aldosterone in Patients with Hypertension

et al. 2007

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To prevent cardiovascular disease, targeting aldosterone synthesis and release may be clinically important.Aldosterone production in the adrenal gland is mediated mainly by the T-type calcium channel in vitro.Efonidipine inhibits both L-and T-type Ca channels. To compare the effects of efonidipine on neurohumoral factors with those of amlodipine, an L-type Ca channel blocker, we studied 40 essential hypertensive outpatients. Forty patients who had been administered amlodipine for more than 1 year were treated with efonidipine for 6 months in place of amlodipine. Substituting efonidipine for amlodipine had no significant effect on clinic systolic blood pressure or the plasma levels of brain natriuretic peptide, norepinephrine or active renin. However, the heart rate was significantly decreased (72.0 ± 1.3 vs. 69.8 ± 1.3 beats/min, p <0.01) and the plasma aldosterone level was also significantly decreased after efonidipine treatment (97.7 ± 7.9 vs. 79.7±5.6 pg/mL, p <0.0001). Changes in the aldosterone

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“…converge to activate adenylyl cyclase and increase cAMP (reviews: Hackenthal et al 1990;Schweda and Kurtz 2004). Interruption of this signalling chain by deletion of the G-protein subunit Gsα (which stimulates adenylyl cyclase) demonstrated that cAMP is the major stimulus for renin synthesis and secretion (Chen et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…These cells are located in the media of the afferent arteriole near the entrance of the vessel into the glomerulus (Hackenthal et al 1990). The regulation of renin synthesis and secretion is complex and several extra-and intrarenal mechanisms contribute to a flexible control according to the needs of the body (Kurtz 1989;Hackenthal et al 1990;Osswald and Quast 1995;Schweda and Kurtz 2004).…”

Section: Introductionmentioning

confidence: 99%

Cyclic AMP increases cytoplasmic free calcium in renin-secreting cells from rat kidney

Laske-Ernst¹,

Chmielnicki²,

Quast³

et al. 2009

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Cellular mechanism of renin release

Cited by 63 publications

References 59 publications

Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria

Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria

Comparison of the Effects of Efonidipine and Amlodipine on Aldosterone in Patients with Hypertension

Cyclic AMP increases cytoplasmic free calcium in renin-secreting cells from rat kidney

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