Cellular Inflammation in Nonarteritic Anterior Ischemic Optic Neuropathy and Its Primate Model

Salgado, Cristian

doi:10.1001/archophthalmol.2011.351

Cited by 83 publications

(90 citation statements)

References 29 publications

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“…80,81 Even more importantly, a similar inflammatory reaction was found in an acute case of NAION studied histologically and immunohistochemically (Figures 8 and 9). 81 Although the mechanism of production of ischaemic injury in these models differs from typical human NAION, the models nevertheless provide insight into the cellular mechanisms involved with ischaemic damage to ganglion cells and may be instrumental in testing future hypotheses for neuroprotective therapy in NAION.…”

Section: Cellular Mechanismssupporting

confidence: 69%

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Miller

Arnold

2014

Eye

184

139

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Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over the age of 50 and is the second most common cause of permanent optic nerve-related visual loss in adults after glaucoma. Patients typically present with acute, painless, unilateral loss of vision associated with a variable visual field defect, a relative afferent pupillary defect, a swollen, hyperaemic optic disc, and one or more flame-shaped peripapillary retinal haemorrhages. The pathogenesis of this condition is unknown, but it occurs primarily in patients with structurally small optic discs that have little or no cup and a variety of underlying vascular disorders that may or may not be known at the time of visual loss. There is no consistently beneficial medical or surgical treatment for the condition, but there are now animal models that allow testing of various potential therapies. About 40% of patients experience spontaneous improvement in visual acuity. Patients in whom NAION occurs in one eye have a 15-19% risk of developing a similar event in the opposite eye over the subsequent 5 years.

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Section: Cellular Mechanismssupporting

confidence: 69%

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Miller

Arnold

2014

Eye

184

139

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“…Bernstein et al (16) evaluated optic nerve changes in primate NAION models where capillary vascular thrombosis was induced by laser light and showed that early post-infarct events revealed inflammatory response and suggested that modulation of inflammation might be useful in the treatment of NAION. Early cellular inflammation plays an important role in NAION (17). Histopathological examination of the optic nerve from a 70 year-old man diagnosed with NAION 20 days before death because of renal failure, pancreatitis and hypercalcemia at 12 hours postmortem revealed infarct with surrounding inflammation (29).…”

Section: Discussionmentioning

confidence: 98%

“…Neutrophil-mediated cellular inflammation has been shown to play a role in the early period of NAION (16,17).…”

mentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy

Polat¹,

Yavaş²,

İnan³

et al. 2015

Balkan Med J

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Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over the age of 50 and is the second most common cause of permanent optic nerverelated visual loss in adults after glaucoma. Although the precise cause of NAION remains elusive, the etiology of NAION is believed to be multifactorial. Aims: To evaluate the utility of neutrophil-to-lymphocyte ratio (NLR) as a simple and readily available prognostic factor for clinical disease activity in patients with NAION. Study Design: Case-control study. Methods: Forty-five patients with the diagnosis of NAION and 50 age-and sex-matched controls with/ without any systemic or ocular diseases except cataract were retrospectively enrolled in the study. Demographic characteristics and laboratory findings including complete blood count of all patients and control subjects were obtained from the electronic medical record.The neutrophil and lymphocyte counts were recorded and the NLR was calculated. Results: White blood cell, neutrophil, NLR and platelet values of the NAION patients were significantly higher than those of the controls (p<0.001, p<0.001, p=0.004, p=0.037, respectively). Initial NLR values were negatively correlated with initial and the third month best corrected visual acuity levels in the study group. The optimum NLR cut-off point for NAION was 1.94. Conclusion: NLR could be considered as a new inflammatory marker for assessment of the severity of inflammation in NAION patients with its quick, cheap, easily measurable property with routine complete blood count analysis.

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“…[4][5][6][7][8] From the histological viewpoint, the modulation of inflammation at an early stage of rAION may be a useful approach in the treatment of NA-AION. [9][10][11][12] After the induction of ON ischemia, the breakdown of the blood-optic nerve barrier (BOB) occurs within hours, 8,13 and the recruitment of extrinsic macrophages and the activation of resident microglia at the ischemic core are identified as early as 3 days after the insult. [14][15][16][17] Functional changes such as in the amplitude of visual-evoked potentials (VEPs) were also mitigated early before the permanent degradation following rAION induction.…”

Section: N Onarteritic Anterior Ischemic Optic Neuropathy (Na-aion)mentioning

confidence: 99%

Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION)

Huang

Wen

Chang

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Cellular Inflammation in Nonarteritic Anterior Ischemic Optic Neuropathy and Its Primate Model

Cited by 83 publications

References 29 publications

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Neutrophil-to-Lymphocyte Ratio as a Marker in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy

Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION)

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