Cellular entry of white spot syndrome virus and antiviral immunity mediated by cellular receptors in crustaceans

Zheng, Suiping; Xu, Jiaoyang; Liu, Haipeng

doi:10.1016/j.fsi.2019.08.011

Cited by 40 publications

(28 citation statements)

References 56 publications

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“…A model of the WSSV life cycle and morphogenesis primarily includes three phases: (1) entry into the host cell, (2) uncoating of the genome followed by replication, and (3) particle assembly and release [9]. The first stage of viral entry into the host cell has been thoroughly studied and involves a wide range of molecular interactions between the WSSV envelope proteins and the host [11]. For example, the major envelope protein VP28 of WSSV plays a vital role in viral entry into the host cells by interacting with several host factors, such as the C-type lectin isolated from the stomach of Marsupenaeus japonicus (MjsvCL) shrimp [12] and the Rab7 GTPase from Penaeus monodon (PmRab7) shrimp [13].…”

Section: Introductionmentioning

confidence: 99%

Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry

Xiao

Niu

et al. 2020

Emerging Microbes & Infections

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Emerging studies have indicated that some penaeidins restrict virus infection; however, the mechanism(s) involved are poorly understood. In the present study, we uncovered that penaeidins are a novel family of antiviral effectors against white spot syndrome virus (WSSV), which antagonize the envelope proteins to block viral entry. We found that the expression levels of four identified penaeidins from Litopenaeus vannamei, including BigPEN, PEN2, PEN3, and PEN4, were significantly induced in hemocytes during the early stage of WSSV infection. Knockdown of each penaeidin in vivo via RNA interference resulted in elevated viral loads and rendered shrimp more susceptible to WSSV, while the survival rate was rescued via the injection of recombinant penaeidins. All penaeidins, except PEN4, were shown to interact with several envelope proteins of WSSV, and all four penaeidins were observed to be located on the outer surface of the WSSV virion. Co-incubation of each recombinant penaeidin with WSSV inhibited virion internalization into hemocytes. More importantly, we found that PEN2 competitively bound to the envelope protein VP24 to release it from polymeric immunoglobulin receptor (pIgR), the cellular receptor required for WSSV infection. Moreover, we also demonstrated that BigPEN was able to bind to VP28 of WSSV, which disrupted the interaction between VP28 and Rab7the Rab GTPase that contributes to viral entry by binding with VP28. Taken together, our results demonstrated that penaeidins interact with the envelope proteins of WSSV to block multiple viral infection processes, thereby protecting the host against WSSV.

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Section: Introductionmentioning

confidence: 99%

Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry

Xiao

Niu

et al. 2020

Emerging Microbes & Infections

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“…In addition White Spot Syndrome virus (WSSV), a pathogen causing a severe epidemic disease in shrimp [98], has emerged as problem in aquaculture. Declarador et al [88] supplemented shrimp (Penaeus monodon) diet with the sulfated polysaccharide (SP) ulvan from Ulva sp and Eteromorpha sp.…”

Section: Seaweedsmentioning

confidence: 99%

“…Among crustaceans, several studies focused on potential antiviral agents against the White spot syndrome virus (WSSV), which is a viral pathogen causing a severe epidemic disease in farmed animals [98]. Several molecules, especially antimicrobial peptides (AMPs), involved in crustacean immune response, were considered as anti-WSSV agents.…”

Section: Crustaceansmentioning

confidence: 99%

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

et al. 2020

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Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea.

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“…Vascular endothelial growth factor receptor (found in the coronas of aged PVP Ag and aged TiO 2 PVP NMs in HH combo) in crustaceans plays a pivotal role in growth, development, cell division and the differentiation of endothelial cells. 67 In mammalian cells, inhibition of the vascular endothelial growth factor receptors have been linked to hypotension and cardiovascular disease and such inhibitors have uses in anticancer and antitumor activity therapies. 68,69 Fig.…”

Section: Functions Of the Most Commonly Identified Proteins In The Nmmentioning

confidence: 99%

Mechanistic insights into toxicity pathways induced by nanomaterials in Daphnia magna from analysis of the composition of the acquired protein corona

Ellis

Lynch

2020

Environ. Sci.: Nano

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Cellular entry of white spot syndrome virus and antiviral immunity mediated by cellular receptors in crustaceans

Cited by 40 publications

References 56 publications

Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry

Penaeidins restrict white spot syndrome virus infection by antagonizing the envelope proteins to block viral entry

Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

Mechanistic insights into toxicity pathways induced by nanomaterials in Daphnia magna from analysis of the composition of the acquired protein corona

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