Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

Riccio, Gennaro; Ruocco, Nadia; Mutalipassi, Mirko; Costantini, Maria; Zupo, Valerio; Coppola, Daniela; Pascale, Donatella de; Lauritano, Chiara

doi:10.3390/biom10071007

Cited by 38 publications

(47 citation statements)

References 250 publications

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“…In the search for new antivirals, the natural products, with their diverse and unique structures and mechanisms of action, have always constituted an important source of inspiration. The nucleoside spongouridine produced by the marine sponges Cryptotethya crypta is one of the examples [ 19 ]. A synthetic analogue of the compound, vidarabine, as an approved drug, inhibits the replication of viral DNA, and is effective in the treatment of herpes simplex virus (HSV-1 and HSV-2) and varicella zoster virus (VZV) [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Cyanometabolites—A Review

et al. 2021

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Global processes, such as climate change, frequent and distant travelling and population growth, increase the risk of viral infection spread. Unfortunately, the number of effective and accessible medicines for the prevention and treatment of these infections is limited. Therefore, in recent years, efforts have been intensified to develop new antiviral medicines or vaccines. In this review article, the structure and activity of the most promising antiviral cyanobacterial products are presented. The antiviral cyanometabolites are mainly active against the human immunodeficiency virus (HIV) and other enveloped viruses such as herpes simplex virus (HSV), Ebola or the influenza viruses. The majority of the metabolites are classified as lectins, monomeric or dimeric proteins with unique amino acid sequences. They all show activity at the nanomolar range but differ in carbohydrate specificity and recognize a different epitope on high mannose oligosaccharides. The cyanobacterial lectins include cyanovirin-N (CV-N), scytovirin (SVN), microvirin (MVN), Microcystisviridis lectin (MVL), and Oscillatoria agardhii agglutinin (OAA). Cyanobacterial polysaccharides, peptides, and other metabolites also have potential to be used as antiviral drugs. The sulfated polysaccharide, calcium spirulan (CA-SP), inhibited infection by enveloped viruses, stimulated the immune system’s response, and showed antitumor activity. Microginins, the linear peptides, inhibit angiotensin-converting enzyme (ACE), therefore, their use in the treatment of COVID-19 patients with injury of the ACE2 expressing organs is considered. In addition, many cyanobacterial extracts were revealed to have antiviral activities, but the active agents have not been identified. This fact provides a good basis for further studies on the therapeutic potential of these microorganisms.

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Section: Introductionmentioning

confidence: 99%

Antiviral Cyanometabolites—A Review

et al. 2021

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“…Marine chemical compounds include polyketides, terpenes, nitrogen containing compounds, and polysaccharides (Uzair et al, 2011). It has been well-documented that marine compounds show antibacterial, antifungal, anti-malarial, and antiviral activities (Choudhary et al, 2017;Riccio et al, 2020). Antiviral activity of marine compounds has been tested against human immunodeficiency virus-1 (HIV-1), herpes simplex virus-2 (HSV-2), polio virus, dengue virus, measles virus, influenza virus, and SARS virus (Yasuhara-Bell and Lu, 2010;Uzair et al, 2011;Gogineni et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Computational Simulations Identified Marine-Derived Natural Bioactive Compounds as Replication Inhibitors of SARS-CoV-2

et al. 2021

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The rapid spread of COVID-19, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a worldwide health emergency. Unfortunately, to date, a very small number of remedies have been to be found effective against SARS-CoV-2 infection. Therefore, further research is required to achieve a lasting solution against this deadly disease. Repurposing available drugs and evaluating natural product inhibitors against target proteins of SARS-CoV-2 could be an effective approach to accelerate drug discovery and development. With this strategy in mind, we derived Marine Natural Products (MNP)-based drug-like small molecules and evaluated them against three major target proteins of the SARS-CoV-2 virus replication cycle. A drug-like database from MNP library was generated using Lipinski’s rule of five and ADMET descriptors. A total of 2,033 compounds were obtained and were subsequently subjected to molecular docking with 3CLpro, PLpro, and RdRp. The docking analyses revealed that a total of 14 compounds displayed better docking scores than the reference compounds and have significant molecular interactions with the active site residues of SARS-CoV-2 virus targeted proteins. Furthermore, the stability of docking-derived complexes was analyzed using molecular dynamics simulations and binding free energy calculations. The analyses revealed two hit compounds against each targeted protein displaying stable behavior, binding affinity, and molecular interactions. Our investigation identified two hit compounds against each targeted proteins displaying stable behavior, higher binding affinity and key residual molecular interactions, with good in silico pharmacokinetic properties, therefore can be considered for further in vitro studies.

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“…Oceans have yielded sixteen approved drugs so far, and dozens of MNPs for clinical trials, the great majority of which are intended for cancer treatment [ 14 ]. However, as far as discovering MNPs are concerned to mitigate antiviral infections, it is mostly an unexplored field as it was highlighted by Riccio et al in a recent review [ 15 ]. Ara A ® is the only marine approved antiviral drug for herpes simplex.…”

Section: Introductionmentioning

confidence: 99%

“…Ara A ® is the only marine approved antiviral drug for herpes simplex. In clinical trials, there is Griffithsin TN , a lectin extracted from a red algae and a macrolide naturally produced by marine bacterial symbionts of the bryozoan Bugula neritina, the previously approved anti-cancer Bryostatin ® , both for human immunodeficiency virus (HIV) [ 15 ]. Recently, PharmaMar publicly announced that the anti-tumor drug Aplidin ® (plitidepsin) revealed higher effect for coronavirus treatment than Ivermictin ® , obtained from soil-derived actinomycete, and synthetic Remdesivir ® , beginning Phase II clinical trials for COVID-19 treatment.…”

Section: Introductionmentioning

confidence: 99%

A Computer-Aided Drug Design Approach to Predict Marine Drug-Like Leads for SARS-CoV-2 Main Protease Inhibition

Gaudêncio

Pereira

2020

Marine Drugs

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The investigation of marine natural products (MNPs) as key resources for the discovery of drugs to mitigate the COVID-19 pandemic is a developing field. In this work, computer-aided drug design (CADD) approaches comprising ligand- and structure-based methods were explored for predicting SARS-CoV-2 main protease (Mpro) inhibitors. The CADD ligand-based method used a quantitative structure–activity relationship (QSAR) classification model that was built using 5276 organic molecules extracted from the ChEMBL database with SARS-CoV-2 screening data. The best model achieved an overall predictive accuracy of up to 67% for an external and internal validation using test and training sets. Moreover, based on the best QSAR model, a virtual screening campaign was carried out using 11,162 MNPs retrieved from the Reaxys® database, 7 in-house MNPs obtained from marine-derived actinomycetes by the team, and 14 MNPs that are currently in the clinical pipeline. All the MNPs from the virtual screening libraries that were predicted as belonging to class A were selected for the CADD structure-based method. In the CADD structure-based approach, the 494 MNPs selected by the QSAR approach were screened by molecular docking against Mpro enzyme. A list of virtual screening hits comprising fifteen MNPs was assented by establishing several limits in this CADD approach, and five MNPs were proposed as the most promising marine drug-like leads as SARS-CoV-2 Mpro inhibitors, a benzo[f]pyrano[4,3-b]chromene, notoamide I, emindole SB beta-mannoside, and two bromoindole derivatives.

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Ten-Year Research Update Review: Antiviral Activities from Marine Organisms

Cited by 38 publications

References 250 publications

Antiviral Cyanometabolites—A Review

Antiviral Cyanometabolites—A Review

Computational Simulations Identified Marine-Derived Natural Bioactive Compounds as Replication Inhibitors of SARS-CoV-2

A Computer-Aided Drug Design Approach to Predict Marine Drug-Like Leads for SARS-CoV-2 Main Protease Inhibition

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