1969
DOI: 10.1084/jem.129.1.185
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Cellular Differentiation of the Immune System of Mice

Abstract: Antibody-forming cells produce, as a rule, only one of several possible species of immunoglobulins at any one time. Apparently, imrnunocytes are differentiated so as to synthesize exclusively antibody of one given antigen-specifidty (1-10), biological activity (11, 12), and immunoglobulin class or subclass (4,(12)(13)(14)(15). Specialization of imrnunocytes is so extreme that only one allotypic variant of a particular immunoglobulin subclass is produced by cells possessing the genetic information for two varia… Show more

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Cited by 37 publications
(20 citation statements)
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“…The physical separation of memory cells for two immunoglobulin classes shows that different cells carry memory for different classes. This conclusion is in agreement with that reached by Hamaoka et al (36) and Shearer et al (24). Our data is also in agreement with Hamaoka et al (36) in showing that 3'G1 memory arises prior to 3'G2 memory.…”
Section: Discussionsupporting
confidence: 83%
“…The physical separation of memory cells for two immunoglobulin classes shows that different cells carry memory for different classes. This conclusion is in agreement with that reached by Hamaoka et al (36) and Shearer et al (24). Our data is also in agreement with Hamaoka et al (36) in showing that 3'G1 memory arises prior to 3'G2 memory.…”
Section: Discussionsupporting
confidence: 83%
“…Class restriction of marrow cells and of the units of response to antigens of SRBC (ASU) has been discussed elsewhere (25). A critique of the limiting dilution approach has also been given in publications of this series.…”
Section: Discussionmentioning
confidence: 99%
“…Assays for Immunocytes and for Hemolytic FooL--The procedures for enumerating plaqueforming cells (direct and indirect) and clnster-forming cells have already been described (3,13,14). The assays were performed on spleen cell suspensions of individual mice in duplicate or triplicate.…”
Section: Methodsmentioning
confidence: 99%
“…Splenic ASU of unprimed and primed mice are committed to the exclusive production of one of the following types of immunocytes: direct hemolytic plaque-forming cells (PFC), indirect hemolytic PFC, and hemagglutinating cluster-forming cells (CFC) (3,13). Thus, splenic ASU engaged in anti-SRBC responses are rather specialized or differentiated cells of the immune system.…”
Section: Marrow-thymus Antigen-sensitive Iyn[tsmentioning
confidence: 99%