Cellular compartments challenged by membrane photo-oxidation

Tsubone, Tayana Mazin; Martins, Waleska K.; Franco, Márcia Silvana Freire; Silva, Maryana N.; Itri, Rosângela; Baptista, Maurı́cio S.

doi:10.1016/j.abb.2020.108665

Cited by 8 publications

(9 citation statements)

References 248 publications

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“…The generation of lipid-truncated aldehydes occurs through β-scission reactions from lipid-derived alkoxyl radicals, which are formed by contact-dependent type I reactions from either the lipid double bond or the lipid hydroperoxide (325) (Scheme 15). Type II reaction exclusively yields lipid hydroperoxides that accumulate in the membranes without affecting permeability that facilitate several oxidation steps (100,101,325,327). However, membrane leakage correlates with an electron transfer reaction that usually causes photobleaching of the photosensitizer (70).…”

Section: Photosensitized Oxidation Of Lipids and Consequences To Biological Membranesmentioning

confidence: 99%

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

Baptista

Cadet

Greer

et al. 2021

Photochem & Photobiology

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137

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Photosensitization reactions have been demonstrated to be largely responsible for the deleterious biological effects of UV and visible radiation, as well as for the curative actions of photomedicine. A large number of endogenous and exogenous photosensitizers, biological targets and mechanisms have been reported in the past few decades. Evolving from the original definitions of the type I and type II photosensitized oxidations, we now provide physicochemical frameworks, classifications and key examples of these mechanisms in order to organize, interpret and understand the vast information available in the literature and the new reports, which are in vigorous growth. This review surveys in an extended manner all identified photosensitization mechanisms of the major biomolecule groups such as nucleic acids, proteins, lipids bridging the gap with the subsequent biological processes. Also described are the effects of photosensitization in cells in which UVA and UVB irradiation triggers enzyme activation with the subsequent delayed generation of superoxide anion radical and nitric oxide. Definitions of photosensitized reactions are identified in biomolecules with key insights into cells and tissues.

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Section: Photosensitized Oxidation Of Lipids and Consequences To Biological Membranesmentioning

confidence: 99%

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

Baptista

Cadet

Greer

et al. 2021

Photochem & Photobiology

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137

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“…Several reports revealed that the photooxidative stress may activate the inducible NO synthase isoform (i.e., iNOS), which catalyzes the L-arginine conversion to citrulline and NO in a Ca +2 -independent manner and the expense of NADPH and O 2 (111). The PDT-induced iNOS activation may virtually increase NO at the micromolar concentration, which reacts with superoxide ion (O −• 2 ) to give peroxynitrite (ONOO − ), a strong oxidant that damages both DNA and unsaturated membrane phospholipids, as reviewed by Tsubone et al (112). Such NO has been shown to modulate tumor PDT-resistance, which was first demonstrated for Photofrin ™ through an in vivo preclinical test to treat cancer (113).…”

Section: Molecular Mechanisms For Tumor Resistance To Pdtmentioning

confidence: 99%

“…Therefore, any process that alleviates proteotoxicity and ERstress might lead to functional consequences, including anticancer immunity (125)(126)(127), as well as chemosensitivity (128). For more detailed information see our recent review (112).…”

Section: Molecular Mechanisms For Tumor Resistance To Pdtmentioning

confidence: 99%

“…To improve clinical outcomes, the combination of Foscan ® -PDT with late inhibitors of autophagy flux might be considered in future studies, which beyond increases to AACD may improve antitumor immunological activity. This combined approach may increase the proteotoxicity and calreticulin surface exposure, instigating a series of immune responses including DC maturation, CD 8+ T cell proliferation, and cytotoxic cytokine secretion (112,125,155,200).…”

Section: The Improvement In the Clinical Outcome Of Cancer Patients Mediated By Pdtmentioning

confidence: 99%

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Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment

et al. 2021

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Cancer is considered an age-related disease that, over the next 10 years, will become the most prevalent health problem worldwide. Although cancer therapy has remarkably improved in the last few decades, novel treatment concepts are needed to defeat this disease. Photodynamic Therapy (PDT) signalize a pathway to treat and manage several types of cancer. Over the past three decades, new light sources and photosensitizers (PS) have been developed to be applied in PDT. Nevertheless, there is a lack of knowledge to explain the main biochemical routes needed to trigger regulated cell death mechanisms, affecting, considerably, the scope of the PDT. Although autophagy modulation is being raised as an interesting strategy to be used in cancer therapy, the main aspects referring to the autophagy role over cell succumbing PDT-photoinduced damage remain elusive. Several reports emphasize cytoprotective autophagy, as an ultimate attempt of cells to cope with the photo-induced stress and to survive. Moreover, other underlying molecular mechanisms that evoke PDT-resistance of tumor cells were considered. We reviewed the paradigm about the PDT-regulated cell death mechanisms that involve autophagic impairment or boosted activation. To comprise the autophagy-targeted PDT-protocols to treat cancer, it was underlined those that alleviate or intensify PDT-resistance of tumor cells. Thereby, this review provides insights into the mechanisms by which PDT can be used to modulate autophagy and emphasizes how this field represents a promising therapeutic strategy for cancer treatment.

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“…Type I reactions can also lead to nonfragmented lipids, like ketones and alcohols, that will not promote membrane disruption (20). A direct consequence of the redox reactions involved in Type I photosensitized oxidations is the chance for photobleaching effects of the PS (21). The drawbacks and benefits of having at least part of the PS suffering from photobleaching to attain more effectiveness in terms of cell killing have not been well acquainted by the scientific literature.…”

Section: Introductionmentioning

confidence: 99%

Assessing Photosensitized Membrane Damage: Available Tools and Comprehensive Mechanisms^†

Rezende

Tasso

Candido

et al. 2021

Photochem & Photobiology

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Lipids are important targets of the photosensitized oxidation reactions, forming important signaling molecules, disorganizing and permeabilizing membranes, and consequently inducing a variety of biological responses. Although the initial steps of the photosensitized oxidative damage in lipids are known to occur by both Type I and Type II mechanisms, the progression of the peroxidation reaction, which leads to important end-point biological responses, is poorly known. There are many experimental tools used to study the products of lipid oxidation, but neither the methods nor their resulting observations were critically compared. In this article, we will review the tools most frequently used and the key concepts raised by them in order to rationalize a comprehensive model for the initiation and the progression steps of the photoinduced lipid oxidation.

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Cellular compartments challenged by membrane photo-oxidation

Cited by 8 publications

References 248 publications

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment

Assessing Photosensitized Membrane Damage: Available Tools and Comprehensive Mechanisms^†

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Cellular compartments challenged by membrane photo-oxidation

Cited by 8 publications

References 248 publications

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms

Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment

Assessing Photosensitized Membrane Damage: Available Tools and Comprehensive Mechanisms†

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Product

Resources

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Assessing Photosensitized Membrane Damage: Available Tools and Comprehensive Mechanisms^†