2012
DOI: 10.1111/rda.12060
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Cellular Characteristics of Cultured Canine Trophoblasts

Abstract: Contents Shallow trophoblast invasion is detrimental in human pregnancies, but represents normal endotheliochorial placentation in dogs. Factors regulating shallow trophoblast invasion into the canine decidua are not well described, but it is known that matrix metalloproteinases (MMPs) play a crucial role in trophoblast invasion in many species. Following the methods previously described for isolating human trophoblasts, canine trophoblasts were isolated using collagenase and trypsin digestions with Percoll de… Show more

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Cited by 6 publications
(7 citation statements)
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“…Data show that the shallow trophoblast invasion in the endotheliochorial placentation of dogs is mainly regulated by matrix metalloproteinases, similar to what is known from humans [165]. Thus, the dog may be worth to consider as a model for disorders of shallow trophoblast invasion in humans [165].…”
Section: Laurasiatheriasupporting
confidence: 53%
See 2 more Smart Citations
“…Data show that the shallow trophoblast invasion in the endotheliochorial placentation of dogs is mainly regulated by matrix metalloproteinases, similar to what is known from humans [165]. Thus, the dog may be worth to consider as a model for disorders of shallow trophoblast invasion in humans [165].…”
Section: Laurasiatheriasupporting
confidence: 53%
“…Since the dog has shallow trophoblast invasion throughout gestation, it may improve the understanding of the underlying reasons and exact mechanisms for pre-eclampsia [164]. Data show that the shallow trophoblast invasion in the endotheliochorial placentation of dogs is mainly regulated by matrix metalloproteinases, similar to what is known from humans [165]. Thus, the dog may be worth to consider as a model for disorders of shallow trophoblast invasion in humans [165].…”
Section: Laurasiatheriamentioning
confidence: 90%
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“…Reportedly (Staun-Ram and Shalev, 2005), the MMP-TIMP interaction controls trophoblast invasion by restricting over or underinvasion into the uterus. In support of this concept, immunohistochemical expression of MMP-2, MMP-9 and TIMP-2 have been detected in isolated canine trophoblast of term placenta (Sahlfeld et al, 2012). Temporally, from pre-parturition to parturition, there appears to be an increase in TIMP-2 mRNA expression as pregnancy advances.…”
Section: Expression Of Molecular Regulatorsmentioning
confidence: 76%
“…Bone morphogenetic protein 4 is believed to regulate the terminal differentiation of chorionic girdle acting paracrinally from chorion, allantochorion and yolk sac through the Sma-and Mad-related protein, a mechanism of signaling by TGFβ superfamily proteins (CabreraSharp et al, 2014). Similarly in dogs, many factors have been shown or suspected to be involved in the regulation of trophoblast migration, invasion, and proliferation in carnivores including endopeptidases and their inhibitors, cytokines, growth factors, hormones, and other factors (Kovacs and Ojeda, 2012 (Sahlfeld et al, 2012) and endometrium (Beceriklisoy et al, 2007). The expression of MMP-2 and MMP-9 peaked at the time of implantation with more MMP-2 than MMP-9 (Beceriklisoy et al, 2007).…”
Section: Expression Of Molecular Regulatorsmentioning
confidence: 99%