Cellular and systemic energy metabolic dysregulation in asthma development—a hypothesis-generating approach

Berdnikovs, Sergejs; Newcomb, Dawn C.; Gebretsadik, Tebeb; Snyder, Brittney M.; Wiggins, Derek; Poleon, Kadijah S.; Hartert, Tina

doi:10.1016/j.jaci.2021.10.024

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…According to a small study, C-peptide may increase with a combination of obesity and atopy in women [ 35 ]. In addition, there is evidence that the concentrations of insulin, C-peptide, leptin and the glucose/insulin ratio are associated with recurrent wheezing in preschool children [ 36 ]. A number of studies indicate an increase in the level of C-peptide in patients with COPD [ 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity

et al. 2022

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The pathogenesis of the development of chronic lung diseases assumes the participation of systemic inflammation factors, as well as hormone-like substances produced by adipose tissue. The aim of this study was to evaluate the associations of certain adipokines/cytokines and chronic bronchitis against the background of abdominal obesity in young people. The study included 1415 people aged 25−44. In total, 115 people were selected by the random numbers method, who were divided into two subgroups: those with chronic bronchitis and abdominal obesity and those with chronic bronchitis without abdominal obesity. A control group of patients with comparable gender and age was also selected. In the group of patients with chronic bronchitis, adiponectin, TNFa and GIP levels were 1.4 times higher. The levels of C-peptide, MCP-1 and PP in the group of chronic bronchitis were 1.3 times higher compared to the control. Adipsin, lipocalin-2, IL-6 and resistin were significantly higher in the group with chronic bronchitis. Glucagon, amylin and ghrelin were 2.2, 2.3 and 3.2 times lower, respectively, in the group of patients with chronic bronchitis. Against the background of abdominal obesity, the probability of having chronic bronchitis increased with an increase in the level of lipocalin-2 and GIP and TNFa.

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Section: Discussionmentioning

confidence: 99%

Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity

et al. 2022

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“…Согласно данным небольшого исследования, Спептид может повышаться при сочетании ожирения и атопии у жен щин [48]. Кроме того, существуют данные о том, что концентрации инсулина, Спептида, лептина и от ношение глюкозы к инсулину связаны с рецидивиру ющими хрипами у детей дошкольного возраста [49]. По данным ряда исследований показано повышение уровня Cпептида у пациентов с ХОБЛ [50][51][52], при этом оценка уровня Спептида и инсулина у лиц с со четаннием АО и бронхолегочных заболеваний не про водилась.…”

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Influence of adipocytokines on the bronchopulmonary system in abdominal obesity

Khudiakova,

Ragino

2023

Pulʹmonologiâ (Mosk.)

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Pathogenesis of chronic lung diseases is assumed to involve systemic inflammation factors, as well as hormone-like substances adipokines produced by adipose tissue, which is an independent endocrine organ. Adipokines cause systemic inflammation under the influence of hypoxemia due to obesity and associated respiratory disorders such as obstructive sleep apnea syndrome, chronic obstructive pulmonary disease, hypoventilation syndrome, etc. However, the influence of specific adipocytes on the development and course of bronchopulmonary diseases remains unclear.Purpose of this review was to evaluate the contribution of some adipocytokines to the development of bronchopulmonary conditions against abdominal obesity. We collected data on adiponectin, adipsin, lipocalin-2, interleukin 6, insulin, glucagon, leptin, monocyte-chemoattractant protein type 1, tumor necrosis factor-α, amylin, glucose-dependent insulinotropic polypeptide, ghrelin, and pancreatic polypeptide in patients with abdominal obesity and bronchopulmonary disorders.Conclusion. The presented data confirm that hormone-like substances produced by adipose tissue make a significant contribution to the severity of respiratory disorders.

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Obesity and Asthma: Metabolic Dysregulation

Holguin

2024

Respiratory Medicine

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Cellular and systemic energy metabolic dysregulation in asthma development—a hypothesis-generating approach

Cited by 4 publications

References 22 publications

Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity

Blood Adipokines/Cytokines in Young People with Chronic Bronchitis and Abdominal Obesity

Influence of adipocytokines on the bronchopulmonary system in abdominal obesity

Obesity and Asthma: Metabolic Dysregulation

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