Cellular and Molecular Targets of Resveratrol on Lymphoma and Leukemia Cells

Frazzi, Raffaele; Guardi, Manuela

doi:10.3390/molecules22060885

Cited by 25 publications

(13 citation statements)

References 81 publications

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“…RSV has been shown to inhibit in vitro growth of several cancer cells, including human acute lymphocytic and non-lymphocytic leukemia cell lines such as HL-60 (promyelocytic leukemia) [2], K562 (chronic myelogenous leukemia) [3], and CEM-C7H2 (T-acute lymphocytic leukemia) [4]. Several mechanisms have been proposed for the growth inhibitory effect of RSV, including induction of leukemia cell differentiation, apoptosis, and cell cycle arrest at the S phase and inhibition of DNA synthesis by inhibiting ribonucleotide reductase or DNA polymerase [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of methoxy stilbenes—analogs of resveratrol—on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells

et al. 2020

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The present study aimed to evaluate the cytotoxicity and its mechanism of five synthetic methoxy stilbenes, namely 3,4,4ʹ-trimethoxy, 3,4,2ʹ-trimethoxy, 3,4,2ʹ,4ʹ-tetramethoxy, 3,4,2ʹ,6ʹ-tetramethoxy, and 3,4,2ʹ,4ʹ,6ʹ-pentamethoxy-trans-stilbenes (MS), in comparison with resveratrol (RSV). Human promyelocytic (HL-60) and monocytic leukemia (THP-1) cells were treated with the tested compounds for 24 h, and cytotoxicity, cell cycle distribution, and apoptosis were evaluated. Significant differences were found in the susceptibility of these cell lines to all stilbenes, including RSV. The THP-1 cells were more resistant to cytotoxic activity of these compounds than HL-60 cells. Among the tested stilbenes, 3,4,4ʹ-tri-MS and 3,4,2ʹ,4ʹ-tetra-MS exhibited higher cytotoxicity toward both cell lines than RSV and the other methoxy stilbenes. This activity might be related to cell cycle arrest at the G2/M phase and induction of apoptosis. In this regard, 3,4,4ʹ-tri-MS and 3,4,2ʹ,4ʹ-tetra-MS at highest concentrations increased the p53 protein level particularly in HL-60 cells. Moreover, treatment with these derivatives increased the ratio of the proapoptotic Bax protein to the antiapoptotic Bcl-xl protein, suggesting the induction of apoptosis through the intrinsic mitochondrial pathway in both cell lines. Further studies are required to fully elucidate the mechanism of these activities.

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Section: Introductionmentioning

confidence: 99%

Effect of methoxy stilbenes—analogs of resveratrol—on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells

et al. 2020

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“…New and old cellular and tissue targets are characterized for resveratrol and derivatives. Ferraz da Costa et al [ 11 ], and Frazzi & Guardi review cellular and molecular targets of resveratrol on lymphoma and leukemia cells [ 12 ], and León et al review the implications of resveratrol on glucose uptake and metabolism [ 13 ]. Finally, Wahab et al [ 14 ] put forward the significance of resveratrol in clinical management of chronic diseases.…”

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confidence: 99%

Special Issue: Improvements for Resveratrol Efficacy

2017

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“…These benefits have resulted in extensive research into finding new natural compounds and revealing their potential mechanisms of actions [ 15 , 16 , 17 ]. Resveratrol (Res) is a dietary phytochemical that has been reported to be efficacious treatment for various ailments by targeting diverse molecular pathways [ 18 , 19 , 20 , 21 ]. The role of Res in the treatment of chronic diseases was established in early 1990s when it was found that this phytochemical possesses significant cardioprotective benefits [ 22 ].…”

Section: Resveratrolmentioning

confidence: 99%

Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities

et al. 2020

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Resveratrol (Res) is a well-known natural product that can exhibit important pharmacological activities such as antioxidant, anti-diabetes, anti-tumor, and anti-inflammatory. An evaluation of its therapeutic effects demonstrates that this naturally occurring bioactive compound can target different molecular pathways to exert its pharmacological actions. Transforming growth factor-beta (TGF-β) is an important molecular pathway that is capable of regulating different cellular mechanisms such as proliferation, migration, and angiogenesis. TGF-β has been reported to be involved in the development of disorders such as diabetes, cancer, inflammatory disorders, fibrosis, cardiovascular disorders, etc. In the present review, the relationship between Res and TGF-β has been investigated. It was noticed that Res can inhibit TGF-β to suppress the proliferation and migration of cancer cells. In addition, Res can improve fibrosis by reducing inflammation via promoting TGF-β down-regulation. Res has been reported to be also beneficial in the amelioration of diabetic complications via targeting the TGF-β signaling pathway. These topics are discussed in detail in this review to shed light on the protective effects of Res mediated via the modulation of TGF-β signaling.

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Cellular and Molecular Targets of Resveratrol on Lymphoma and Leukemia Cells

Cited by 25 publications

References 81 publications

Effect of methoxy stilbenes—analogs of resveratrol—on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells

Effect of methoxy stilbenes—analogs of resveratrol—on the viability and induction of cell cycle arrest and apoptosis in human myeloid leukemia cells

Special Issue: Improvements for Resveratrol Efficacy

Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities

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