Cellular and molecular insights into the roles of visfatin in breast cancer cells plasticity programs

Rajput, Pradeep Kumar; Sharma, Jiten R.; Yadav, Umesh C. S.

doi:10.1016/j.lfs.2022.120706

Cited by 6 publications

(5 citation statements)

References 139 publications

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“…Chondrosarcoma, a heterogeneous malignant bone tumor with a high incidence of lymphangiogenesis and a feature to spread, consists of a vital component. Visfatin is closely associated with oncogenesis, and elevated levels of visfatin expression have been related to poorer prognoses in different cancer types 40–42 . In our previous studies, we discovered that visfatin promotes PDGF‐C‐dependent angiogenesis and metastasis in human chondrosarcoma 21,22 .…”

Section: Discussionmentioning

confidence: 96%

“…Visfatin is closely associated with oncogenesis, and elevated levels of visfatin expression have been related to poorer prognoses in different cancer types. [40][41][42] In our previous studies, we discovered that visfatin promotes PDGF-C-dependent angiogenesis and metastasis in human chondrosarcoma. 21,22 We previously used the orthotopic in vivo model to provide evidence that overexpression of visfatin augments chondrosarcoma metastasis to the lungs.…”

Section: Discussionmentioning

confidence: 99%

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The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma

Song,

Wu,

Lin

et al. 2024

Environmental Toxicology

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Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous tissue and is associated with lung metastases. Extracellular vesicles called exosomes are primarily used as mediators of intercellular signal transmission to control tumor metastasis. Visfatin is an adipokine reported to enhance tumor metastasis, but its relationship with exosome generation in chondrosarcoma motility remains undetermined. Our results found that overexpressing visfatin augments the production of exosomes from chondrosarcoma cells. Visfatin‐treated chondrosarcoma exosomes educate macrophage polarization towards the M2 but not M1 phenotype. Interestingly, M2 macrophages polarized by exosomes return to chondrosarcoma cells to facilitate cell motility. According to these findings, chondrosarcoma cells emit more exosomes when treated with visfatin. The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma

Song,

Wu,

Lin

et al. 2024

Environmental Toxicology

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“…Visfatin, also known as NAMPT, is synthesized and secreted by tumor myeloid cells, promoting angiogenesis by targeting endothelial cells [ 39 ]. In breast cancer, NAMPT has been shown to facilitate EndMT [ 40 ]. TGFb signaling, a critical inducer of tumor EndMT [ 41 ], has been proven to trigger EndMT in various cancers, including melanoma, esophageal, colon, and lung cancers [ [42] , [43] , [44] , [45] ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis of MMP14+ myeloid cells affecting endothelial-mesenchymal transformation and immune microenvironment in glioma

Luo,

Quan,

et al. 2024

Heliyon

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“…Chondrosarcoma, a heterogeneous malignant bone tumor with a high incidence of lymphangiogenesis and a propensity to spread, consists of a vital component [25]. Visfatin is closely associated with oncogenesis, and elevated levels of visfatin expression have been related to poorer prognoses in various cancer types [26][27][28][29]. In our previous studies, we discovered that visfatin promotes PDGF-C-dependent angiogenesis and metastasis in human chondrosarcoma [19,20].…”

Section: Discussionmentioning

confidence: 99%

Visfatin Facilitates VEGF-D-Induced Lymphangiogenesis through Activating HIF-1α and Suppressing miR-2277-3p in Human Chondrosarcoma

Song,

Hsieh,

Yang

et al. 2024

IJMS

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Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous tissue and is associated with lung metastases. Lymphangiogenesis plays an essential role in cancer metastasis. Visfatin is an adipokine reported to enhance tumor metastasis, but its relationship with VEGF-D generation and lymphangiogenesis in chondrosarcoma remains undetermined. Our results from clinical samples reveal that VEGF-D levels are markedly higher in chondrosarcoma patients than in normal individuals. Visfatin stimulation promotes VEGF-D-dependent lymphatic endothelial cell lymphangiogenesis. We also found that visfatin induces VEGF-D production by activating HIF-1α and reducing miR-2277-3p generation through the Raf/MEK/ERK signaling cascade. Importantly, visfatin controls chondrosarcoma-related lymphangiogenesis in vivo. Therefore, visfatin is a promising target in the treatment of chondrosarcoma lymphangiogenesis.

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Cellular and molecular insights into the roles of visfatin in breast cancer cells plasticity programs

Cited by 6 publications

References 139 publications

The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma

The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma

Bioinformatics analysis of MMP14+ myeloid cells affecting endothelial-mesenchymal transformation and immune microenvironment in glioma

Visfatin Facilitates VEGF-D-Induced Lymphangiogenesis through Activating HIF-1α and Suppressing miR-2277-3p in Human Chondrosarcoma

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