Cellular and molecular basis of the increased splenic hemopoiesis in mice treated with bacterial cell wall components.

Staber, F G; Metcalf, Donald

doi:10.1073/pnas.77.7.4322

Cited by 29 publications

(10 citation statements)

References 25 publications

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“…While they did not determine the stimula tory mechanism, Starber and Metcalf [6] and MacVittie and Weinberg [14] reported that the number of pluripotent hematopoietic stem cells (CFU-s) also increased in the spleens of mice treated with LPS.…”

Section: Discussionmentioning

confidence: 99%

“…Staber and Metcalf [6] showed that CFU-gm and pluripotent hematopoietic stem cells (CFU-s) increased in the spleen of mice treated with LPS. Re cently, Van den Engh and Bol [7] reported that serum post-LPS exposure contained two different activities: stimulating activity which might be identical to colony-stimulat ing factor (CSF), and an activity which aug mented the effect of CSF.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mouse Peritoneal Macrophages Produce CFU-gm and CFU-meg Growth-Promoting Factors

Sugimoto

Wakabayashi²,

Hirose³

et al. 1988

Pathobiology

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The effect of peritoneal macrophage-conditioned medium (macrophage CM) from lipopolysaccharide-injected mice on granulocyte-macrophage colony (CFU-gm) and megakaryocyte colony (CFU-meg) formation was examined using a plasma clot culture system. Macrophage CM stimulated mouse bone marrow cells to form CFU-gm and CFU-meg in the presence of pokeweed mitogen-stimulated spleen cell-conditioned medium, but it had no effect on colony formation in the absence of exogenous colony-stimulating factors (CSF). CFU-gm and CFU-meg colony formation was enhanced by low concentrations of exogenous GM-CSF or Meg-CSF alone. These data demonstrate that macrophage CM contains an activity that sensitized CFU-gm and CFU-meg to exogenous CSF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mouse Peritoneal Macrophages Produce CFU-gm and CFU-meg Growth-Promoting Factors

Sugimoto

Wakabayashi²,

Hirose³

et al. 1988

Pathobiology

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“…LPS also directly affects colony formation by increasing the responsiveness of progenitor cells to GM-CSF (Moore et al, 1980). There are few data on the effects of LTA or PG on the induction of GM-CSF, but PG from Escherichia coli (Staber & Metcalf, 1980) and synthetic muramyldipeptide (Galelli & Chedid, 1983) have been shown to increase production of GM-CSF in vivo.…”

Section: Gm-csf Responsesmentioning

confidence: 99%

Biological activities of lipoteichoic acid and peptidoglycan--teichoic acid of Bacillus subtilis 168 (Marburg)

Himanen

Pyhälä²,

Ölander³

et al. 1993

Journal of General Microbiology

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To evaluate the suitability of Bacillus subtilis as a production host of heterologous proteins for pharmaceutical purposes, we assessed the biological activity of this bacterium and its major cell envelope components, lipoteichoic acid (LTA) and peptidoglycan-teichoic acid complex (PGTA) in several eukaryotic effector assays. LTA and PGTA were found to be non-toxic for mice and guinea-pigs in a short-term toxicity assay. PGTA was weakly pyrogenic and weakly mitogenic. Both LTA and PGTA acted as immunologic adjuvants in mice and when injected in mice, also caused an increase in the number of granulocyte-monocyte colony-forming cells in the bone marrow probably via stimulation of production of granulocytemacrophage colony-stimulating factor.

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“…Approximately 10 to 30% of the spleen of a healthy naive mouse is composed of erythroid cells, but this proportion rises to 80 to 85% at the peak of Salmonella-induced splenomegaly (33). This striking effect of Salmonella on erythroid development has been largely ignored despite the fact that several studies over the last 40 years have noted that bacterial endotoxin can affect erythropoiesis (35)(36)(37)(38).…”

mentioning

confidence: 99%

Salmonella Infection Enhances Erythropoietin Production by the Kidney and Liver, Which Correlates with Elevated Bacterial Burdens

Benoun

Weiskopf

et al. 2016

Infect Immun

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Salmonella infection profoundly affects host erythroid development, but the mechanisms responsible for this effect remain poorly understood. We monitored the impact of Salmonella infection on erythroid development and found that systemic infection induced anemia, splenomegaly, elevated erythropoietin (EPO) levels, and extramedullary erythropoiesis in a process independent of Salmonella pathogenicity island 2 (SPI2) or flagellin. The circulating EPO level was also constitutively higher in mice lacking the expression of signal-regulatory protein ␣ (SIRP␣). The expression level of EPO mRNA was elevated in the kidney and liver but not increased in the spleens of infected mice despite the presence of extramedullary erythropoiesis in this tissue. In contrast to data from a previous report, mice lacking EPO receptor (EPOR) expression on nonerythroid cells (EPOR rescued) had bacterial loads similar to those of wild-type mice following Salmonella infection. Indeed, treatment to reduce splenic erythroblasts and mature red blood cells correlated with elevated bacterial burdens, implying that extramedullary erythropoiesis benefits the host. Together, these findings emphasize the profound effect of Salmonella infection on erythroid development and suggest that the modulation of erythroid development has both positive and negative consequences for host immunity.

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Cellular and molecular basis of the increased splenic hemopoiesis in mice treated with bacterial cell wall components.

Cited by 29 publications

References 25 publications

Mouse Peritoneal Macrophages Produce CFU-gm and CFU-meg Growth-Promoting Factors

Mouse Peritoneal Macrophages Produce CFU-gm and CFU-meg Growth-Promoting Factors

Biological activities of lipoteichoic acid and peptidoglycan--teichoic acid of Bacillus subtilis 168 (Marburg)

Salmonella Infection Enhances Erythropoietin Production by the Kidney and Liver, Which Correlates with Elevated Bacterial Burdens

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