Cell-type-specific silence in thalamocortical circuits precedes hippocampal sharp-wave ripples

Chambers, Anna R.; Berge, Christoffer Nerland; Vervaeke, Koen

doi:10.1016/j.celrep.2022.111132

Cited by 15 publications

(14 citation statements)

References 76 publications

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“…Notably, in the ~1 s-long interval before the ripple centers, the calcium activity of elevated and suppressed sub-populations was suppressed and elevated, respectively ( Figure 3Bii ). The pre-ripple modulation of the two sub-populations is consistent with the excitatory and inhibitory ramps observed in Chambers et al, 2022 . These results show that, despite the presence of significant reduction in population membrane voltage in aRSC, a substantially large sub-population of neurons increases their calcium activity during awake ripples.…”

Section: Resultssupporting

confidence: 81%

“…This mechanism has been reported in gRSC where peri-ripple hippocampal excitatory input activates, via subiculum, the inhibitory interneurons in gRSC, which leads to suppression of firing of many pyramidal neurons ( Nitzan et al, 2020 ; Opalka et al, 2020 ). Similarly, a recent work found that inhibitory interneurons in superficial layers of aRSC increase their firing during awake ripples which, in turn, could suppress the activity of some excitatory neurons ( Chambers et al, 2022 ).…”

Section: Discussionmentioning

confidence: 78%

“…This observation supports the hypothesis that a local awake down-state could occur in aRSC after occurrence of a portion of hippocampal ripples. However, a recent work ( Chambers et al, 2022 ) reported that, out of 33 aRSC neurons whose membrane potentials were recorded, only 1 showed up-/down-states transitions (bimodal membrane potential distribution). Still, a portion (10 out of 30) of the remaining unimodal neurons showed an abrupt post-ripple hyperpolarization.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is less likely that thalamic projections contribute to the peri-awake-ripple aRSC activity modulation because multiple studies have observed the suppression of the majority of thalamic neurons during awake ripples ( Logothetis et al, 2012 ; Nitzan et al, 2022 ; Yang et al, 2019 ). Moreover, peri-awake-ripple suppression of thalamic axons projecting to the first layer of aRSC is reported ( Chambers et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

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Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

Abadchi

Rezaei

Knöpfel

et al. 2023

eLife

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Coordinated peri-ripple activity in the hippocampal-neocortical network is essential for mnemonic information processing in the brain. Hippocampal ripples likely serve different functions in sleep and awake states. Thus, the corresponding neocortical activity patterns may differ in important ways. We addressed this possibility by conducting voltage and glutamate wide-field imaging of the neocortex with concurrent hippocampal electrophysiology in awake mice. Contrary to our previously published sleep results, deactivation and activation were dominant in post-ripple neocortical voltage and glutamate activity, respectively, especially in the agranular retrosplenial cortex (aRSC). Additionally, the spiking activity of aRSC neurons, estimated by two-photon calcium imaging, revealed the existence of two subpopulations of excitatory neurons with opposite peri-ripple modulation patterns: one increases and the other decreases firing rate. These differences in peri-ripple spatiotemporal patterns of neocortical activity in sleep versus awake states might underlie the reported differences in the function of sleep versus awake ripples.

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Section: Resultssupporting

confidence: 81%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

Abadchi

Rezaei

Knöpfel

et al. 2023

eLife

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show abstract

“…Moreover, the CT-TC system has been widely used to study axon guidance mechanisms, decode the components implicated in the development of cortical circuits, comprehend the development of sensory systems (Blakemore and Molnar, 1990;López-Bendito, 2018), and investigate the mechanisms involved in anatomical and functional circuit plasticity following a sensory loss (Kwan and Dan, 2012;Chambers et al, 2022).…”

Section: Animal Models To Study Cortico-thalamic Developmentmentioning

confidence: 99%

Cortico-thalamic development and disease: From cells, to circuits, to schizophrenia

Salavarria

Dell’Amico²,

D’Agostino³

et al. 2023

Front. Neuroanat.

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The human brain is the most complex structure generated during development. Unveiling the ontogenesis and the intrinsic organization of specific neural networks may represent a key to understanding the physio-pathological aspects of different brain areas. The cortico-thalamic and thalamo-cortical (CT-TC) circuits process and modulate essential tasks such as wakefulness, sleep and memory, and their alterations may result in neurodevelopmental and psychiatric disorders. These pathologies are reported to affect specific neural populations but may also broadly alter physiological connections and thus dysregulate brain network generation, communication, and function. More specifically, the CT-TC system is reported to be severely affected in disorders impacting superior brain functions, such as schizophrenia (SCZ), bipolar disorder, autism spectrum disorders or epilepsy. In this review, the focus will be on CT development, and the models exploited to uncover and comprehend its molecular and cellular mechanisms. In parallel to animal models, still fundamental to unveil human neural network establishment, advanced in vitro platforms, such as brain organoids derived from human pluripotent stem cells, will be discussed. Indeed, organoids and assembloids represent unique tools to study and accelerate fundamental research in CT development and its dysfunctions. We will then discuss recent cutting-edge contributions, including in silico approaches, concerning ontogenesis, specification, and function of the CT-TC circuitry that generates connectivity maps in physiological and pathological conditions.

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Progress on the hippocampal circuits and functions based on sharp wave ripples

Xie

Zhen

Guo

et al. 2023

Brain Research Bulletin

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Cell-type-specific silence in thalamocortical circuits precedes hippocampal sharp-wave ripples

Cited by 15 publications

References 76 publications

Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

Cortico-thalamic development and disease: From cells, to circuits, to schizophrenia

Progress on the hippocampal circuits and functions based on sharp wave ripples

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