Cell-Type-Specific Manipulation Reveals New Specificity in the Neocortical Microcircuit

Naka, Alexander

doi:10.1523/jneurosci.1297-15.2015

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…If so, this disynaptic motif would represent an interesting inversion of the asymmetric connectivity from IT cells onto PT cells. Emerging evidence suggests that indirect circuits of this sort underlie stereotyped inhibitory interactions between excitatory cell types in cortex (Adesnik and Scanziani, 2010 ; Olsen et al, 2012 ; Xue et al, 2014 ; Yamawaki and Shepherd, 2015 ); these circuits might be thought of as inhibitory “pathways” in the cortical microcircuit (Naka, 2015 ) and will be an important topic for future study.…”

Section: Recurrent Intralaminar Inhibition Within Layermentioning

confidence: 99%

Inhibitory Circuits in Cortical Layer 5

Naka

Adesnik

2016

Front. Neural Circuits

105

107

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Inhibitory neurons play a fundamental role in cortical computation and behavior. Recent technological advances, such as two photon imaging, targeted in vivo recording, and molecular profiling, have improved our understanding of the function and diversity of cortical interneurons, but for technical reasons most work has been directed towards inhibitory neurons in the superficial cortical layers. Here we review current knowledge specifically on layer 5 (L5) inhibitory microcircuits, which play a critical role in controlling cortical output. We focus on recent work from the well-studied rodent barrel cortex, but also draw on evidence from studies in primary visual cortex and other cortical areas. The diversity of both deep inhibitory neurons and their pyramidal cell targets make this a challenging but essential area of study in cortical computation and sensory processing.

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