Cell Therapy in Practice

Figueiredo, Gustavo S.; Havilland, Julian R. De; Lako, Majlinda; Figueiredo, Francisco C

doi:10.1002/9781118743362.ch8

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…It must also be pointed out that since aluminum was chosen as the electrode material in our design, the system developed should be able to sustain high temperature and pressure, commonly used for sterilization and depyrogenation purposes [30,31] (see supplementary materials D). In addition, the software platform here also allows us to easily adjust different parameters.…”

Section: Discussionmentioning

confidence: 99%

An electroporation platform for Erlotinib resistance screening in living non-small cell lung cancer (NSCLC) cells

Yan

Hui

Fong

et al. 2018

Biomed. Phys. Eng. Express

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An electroporation device was developed to introduce transient membrane pores and, consequently, enhance membrane permeability in living cells in a controllable manner. The validity of this platform was assessed on six non-small cell lung cancer (NSCLC) cell lines using different fluorescent dyes. Interestingly, it was found that the electroporation efficiency of these cells, i.e. the percentage of cells with membrane pores created, decreases significantly (from ∼60% to 30%) as their resistivity against Erlotinib increases, demonstrating the potential of such approach as a screening tool for assessing drug resistance in tumours in the future. Furthermore, we showed that the inverse relationship between the electroporation efficiency and Erlotinib resistance is likely due to the fact that NSCLC cell lines with higher drug resistivity appear to have lower cortical tensions and hence make it harder for membrane pores to be created, consistent with existing electroporation theories.

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Section: Discussionmentioning

confidence: 99%

An electroporation platform for Erlotinib resistance screening in living non-small cell lung cancer (NSCLC) cells

Yan

Hui

Fong

et al. 2018

Biomed. Phys. Eng. Express

View full text Add to dashboard Cite

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Novels of modern domestic legislation in the field of genomic therapy and the prospects for its implementation in everyday life

Васильев

2022

TSU Herald. Soc Econ Law Res

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Recent events in Russia and in the world have shown the high importance of medicine for modern society. It became obvious that a large number of threats are concentrated from the point of view of the consistency of the healthcare system, which can be ensured by coordinated actions of state structures based on a high-quality regulatory legal framework. On the other hand, new means and methods of treating various diseases seem to be important. One of these areas of high-tech medicine is the diagnosis and editing of the human genome. There is practically no normative legal regulation of this activity, despite the fact that modern legal science is replete with proposals in this regard and notes an acute shortage of this regulation. Nevertheless, these medical technologies had some influence on minor changes in the legal regulation of this area, including the special powers of the federal territory “Sirius”, revision of the system of state control and supervision over the production and distribution of biomedical cell products and some progress in causing and compensating harm from conducting genomic research. The scientific novelty of this work is the conclusion about the impact of genomic medicine on legal regulation in Russia, as well as proposals for further improvement of such work. The purpose of the study is to analyze the latest legislative innovations to assess the impact of modern medical technologies on them, as well as to determine the main directions for further improving the legal system in this area. Methodology. To carry out this study, we analyzed the domestic legal regulation on the issue of genomic therapy in its dynamics over the past few years, used the method of expert assessments, the comparative legal method. The main suggestions were made by the modeling method. Key conclusions are made based on general philosophical methods of scientific knowledge — analysis and synthesis, deduction and induction.

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Cell Therapy in Practice

Cited by 2 publications

References 2 publications

An electroporation platform for Erlotinib resistance screening in living non-small cell lung cancer (NSCLC) cells

An electroporation platform for Erlotinib resistance screening in living non-small cell lung cancer (NSCLC) cells

Novels of modern domestic legislation in the field of genomic therapy and the prospects for its implementation in everyday life

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