Cell Therapy for Wound Healing

Abstract

In covering wounds, efforts should include utilization of the safest and least invasive methods with goals of achieving optimal functional and cosmetic outcome. The recent development of advanced wound healing technology has triggered the use of cells to improve wound healing conditions. The purpose of this review is to provide information on clinically available cell-based treatment options for healing of acute and chronic wounds. Compared with a variety of conventional methods, such as skin grafts and local flaps, the cell therapy technique is simple, less time-consuming, and reduces the surgical burden for patients in the repair of acute wounds. Cell therapy has also been developed for chronic wound healing. By transplanting cells with an excellent wound healing capacity profile to chronic wounds, in which wound healing cannot be achieved successfully, attempts are made to convert the wound bed into the environment where maximum wound healing can be achieved. Fibroblasts, keratinocytes, adipose-derived stromal vascular fraction cells, bone marrow stem cells, and platelets have been used for wound healing in clinical practice. Some formulations are commercially available. To establish the cell therapy as a standard treatment, however, further research is needed. http://dx.doi. org/10.3346/jkms.2014.29.3.311 • J Korean Med Sci 2014 29: 311-319 We all experience our fair share of wounds during the course of our lives. The art and science of wound healing are complex and intriguing. During the past few decades, various wound healing technologies for promoting cell activity or minimizing scar formation have been developed and some of them are being actively used at present. The aim of this paper is to provide information on cell-based treatment options in clinical setting for healing of acute and chronic wounds. Keywords

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

“…To date, keratinocytes, fibroblasts and adipose-derived stromal vascular fraction (SVF) cells are being applied in a clinical setting of human skin wounds. They are mainly combined with artificial dermis to optimize wound healing [166]. Tissue engineered skin has been developed due to restrictions correlated with autografts.…”

Adipose tissue stromal vascular fraction in the treatment of full thickness burns in rats

“…The development of interventions to reduce hypertrophic scarring, promote morphological reconstruction and functional recovery are necessary in order to achieve better results 7 .…”

Preformed gelatin microcryogels as injectable cell carriers for enhanced skin wound healing

“…In chronic wounds of clinical patients, mitotic activities of local cells in the lesion have notably decreased compared with normal controls [1]. Besides, insufficient blood supply and synthesis of growth factors and ECM are the reasons for refractory wound healing.…”