Cell Surface Molecules in Basal Cell Carcinomas

Pentel, Mary T.; Helm, Klaus F.; Maloney, Mary E.

doi:10.1111/j.1524-4725.1995.tb00712.x

Cited by 9 publications

(12 citation statements)

References 23 publications

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“…Many human tumours such as lung, breast, gastric, colon, pancreas, renal and prostate carcinomas have been shown to express different integrin heterodimers [4,14,21,39,64,65,82,84,85,105,107,160,161]. Upon fixation of an integrin to its extracellular ligand the ensuing signalling cascade can affect cell migration [24,30,31,73,78,104,128].…”

Section: Stroma and Tumour Cell Migrationmentioning

confidence: 99%

The multiple roles of tumour stroma

1997

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Since the work of Judah Folkman in the 1970s demonstrating the importance of vascularization on tumour growth the many roles played by tumour stroma have been demonstrated. Vascular endothelial growth factor/vascular permeability factor appears to be the main in vivo inducer of both stromal blood vessels and other components of the tumour stroma. Its action is probably mediated through its strong and long-lasting effect on microvascular permeability leading to fibrin extravasation and organisation ("tumours are wounds that do not heal"). During tumour invasion, stromal fibroblasts participate in the degradation of the extracellular matrix (ECM) by secreting matrix degrading proteases as well as their downstream-activators. Stroma derived factors such as scatter factor/hepatocyte growth factor as well as interactions between neoplastic cells and the ECM can play a role in both tumour cell migration and proliferation. The ECM may also act as a reservoir for growth factors. A novel transcription factor encoded by the c-ets 1 proto-oncogene is likely to be involved in the transcriptional regulation of both tumour vascularization and invasion. This contribution summarizes recent developments in the tumour stroma field.

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Section: Stroma and Tumour Cell Migrationmentioning

confidence: 99%

The multiple roles of tumour stroma

1997

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“…BCCs manifest a keratin profile similar to that of the lower part of the hair follicle 60 and that is therefore distinct from that of the adjacent epidermal basal layer epithelia. 60 In particular, and held to reflect their derivation from basaloid epithelia, BCCs express keratins type 5, 6 61 and 14 62 and also alpha 2 and beta 1 integrins 63 in a fashion that does not correlate well to tumor subtype. The expression of CD10 supports deriva- Figure 16 Recurrent BCC: histomorphology.…”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinoma: biology, morphology and clinical implications

2006

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Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

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“…A clue to this poor immunodetection (surveillance) and deficient cell mediated immune response may reside in the observation that BCC epithelial cells are deficient in cell surface receptors (ICAM‐1 and LAF‐3) that bind to appropriately activated lymphocytes. This binding step is required for lymphocyte‐associated immune reactions and tumor cell destruction to occur 8,9 . Furthermore, it has been noted that BCC cells produce cytokines interleukin (IL)‐10 and IL‐4 that down regulate the immune response 10…”

Section: Biology and Immunologymentioning

confidence: 99%

“…This binding step is required for lymphocyte-associated immune reactions and tumor cell destruction to occur. 8,9 Furthermore, it has been noted that BCC cells produce cytokines interleukin (IL)-10 and IL-4 that down regulate the immune response. 10 However, the situation is dramatically altered if one examines the microscopic state of a spontaneously regressing BCC.…”

Section: Biology and Immunologymentioning

confidence: 99%