Cell sex determines anoikis resistance in vascular smooth muscle cells

Straface, Elisabetta; Vona, Rosa; Gambardella, Lucrezia; Ascione, Barbara; Marino, Maria; Bulzomi, Paola; Canu, Silvia; Coinu, R; Rosano, Giuseppe; Malorni, Walter; Franconi, Flavia

doi:10.1016/j.febslet.2009.09.052

Cited by 52 publications

(40 citation statements)

References 28 publications

(43 reference statements)

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“…However, slight variations in the intracellular redox environment and in the detoxification machinery can have profound effects on a number of intracellular signaling molecules, thereby modifying cell functions and cell fate. In this context, it was recently suggested that ROS production and detoxification machinery are sex-gender dependent and that XX and XY cells have a determining role in the response to oxidative insults Straface et al, 2009). In particular, the basal differences in the redox state of freshly isolated cells from males and females indicate that XX cells have higher GSH content and that this can provide these cells with greater protection from oxidants (see below) .…”

Section: Cytology and Cytopathology In Male And Female Cells 721 Omentioning

confidence: 96%

Nutrition and human health from a sex–gender perspective

Marino

Masella

Bulzomi

et al. 2011

Molecular Aspects of Medicine

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108

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Section: Cytology and Cytopathology In Male And Female Cells 721 Omentioning

confidence: 96%

Nutrition and human health from a sex–gender perspective

Marino

Masella

Bulzomi

et al. 2011

Molecular Aspects of Medicine

Self Cite

123

108

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“…Not only are males more at risk due to androgens, it now appears that SMCs from female donors are more resistant to apoptosis [16]. The observations were made in the context of resistance to radiation injury, but the mechanism involves cell damage by reactive oxygen species, which has been implicated in AAA progression [17].…”

Section: Sex Differences In Susceptibility To Aortic Aneurysmsmentioning

confidence: 98%

Novel Genetic Mechanisms for Aortic Aneurysms

Tromp

Kuivaniemi

Hinterseher

et al. 2010

Curr Atheroscler Rep

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Aortic aneurysms occur in the thoracic and abdominal sections of the aorta and are a deadly late-age-at-onset disease with complex pathobiology. Currently, the number of published genome-wide analyses including microarray-based expression profiling, DNA linkage studies, and genetic association studies is still limited and it is difficult to make generalizations about the disease pathogenesis or genetic risk factors contributing to aortic aneurysms, but it appears that thoracic aortic aneurysms differ in many ways from abdominal aortic aneurysms. Characterization of diseases at the molecular level is likely to lead to more accurate diagnoses and the use of "genomic nosology" of disease. The biggest future challenge will be to translate the genomic information to the clinic and improve our understanding of the disease processes, help us to develop better diagnostic tools, and lead to the design of new ways to manage aortic aneurysms in the era of personalized medicine.

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“…Their results confirmed that number of detached cells in female were lower both prior to UV radiation and after radiation. 101 A series of studies have shown sex-dependent interactions between SMCs and nitric oxide (NO), a molecule known to inhibit the development of neointimal hyperplasia. 42,43 Hogg et al evaluated the efficacy of NO at inhibiting the vascular SMC proliferation, migration and cell cycle progression in vitro, as well as neointimal hyperplasia in vivo.…”

Section: Atherosclerosismentioning

confidence: 99%

Understanding the Role of Sex in Heart Valve and Major Vascular Diseases

Masjedi

Ferdous

2015

Cardiovasc Eng Tech

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Cardiovascular disease (CVD) is the major cause of mortality in the elderly population. The cost of CVD treatment and surgeries was over $300 billion in the United States alone in 2010, making this disorder a critical healthcare issue. Many studies have suggested sex as a risk factor for heart valve and major vascular diseases, such as aortic valve stenosis, mitral prolapse and regurgitation, atherosclerosis, coronary artery disease, and abdominal aortic aneurysm. Unfortunately, only a handful of studies have illustrated the role of sex in the etiology and progression of these disorders. Moreover, knowledge of biomolecular factors that affect these diseases in men and women is very limited. Numerous clinical studies have revealed obvious differences in the prevalence of these diseases between the sexes. These reports were supported by a few molecular and cellular physiology studies that associated this difference to sex and sex hormones. In particular, male sex has commonly been identified as a risk factor for majority of heart valve and vascular diseases, whereas females have been identified as higher risk for certain disorders as well. In addition, menopause is a critical issue that turns the tables against women and enhances complications in their cardiovascular structure due to hormonal change. In this review, major vascular and heart valve diseases for which sex is associated as a risk factor have been reviewed to highlight the importance of this risk factor in CVDs.

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Cell sex determines anoikis resistance in vascular smooth muscle cells

Cited by 52 publications

References 28 publications

Nutrition and human health from a sex–gender perspective

Nutrition and human health from a sex–gender perspective

Novel Genetic Mechanisms for Aortic Aneurysms

Understanding the Role of Sex in Heart Valve and Major Vascular Diseases

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