Cell Senescence in the Aging Kidney

TXNIP regulates AKT‐mediated cellular senescence by direct interaction under glucose‐mediated metabolic stress

“…One of the organs sensitive to oxidative stress, which increases susceptibility to apoptosis and is associated with delayed repair and regeneration, is the kidney (Yang & Fogo, 2010). Kidney damage is associated with many health problems in the elderly, including renal cancer and kidney failure (Melk et al, 2003).…”

Renal Allograft Fibrosis: Biology and Therapeutic Targets

“…To a certain extent TECs can compensate for stress, as in selective albuminuria, however, if the injury gets more pronounced, the adaptive response will lead to fibrosis and progressive kidney disease (126). Processes involved in mediating the profibrotic response include TEC senescence (6,127,128), apoptosis (129,130), autophagy (131,132), and endoplasmic reticulum stress (133,134), however, many of these processes can also have beneficial effects under certain conditions (135,136). Another process leading to profibrotic activation of TECs is cell cycle arrest (137).…”

The Aging Kidney Phenotype and Systemically Derived Stem Cells

“…The end result was the creation of GlomBase and GlomNet. [1][2][3] GlomBase identified over 300 novel transcripts having elevated glomerular expression but with ill-defined function. The need for an efficient, reliable, and relevant method to evaluate these candidate genes in determining their potential for interrogating glomerular disease is crucial.…”

“…1 The source of humoral factors or cells that might be involved in either the repair of renal injury or the normal replacement of parenchymal cells is now a topic of considerable research and debate. [2][3][4][5][6][7][8][9][10][11][12][13] In part, the debates may result from the fact that the models chosen to examine the questions have been quite diverse, namely organ development, responses to acute injury, or those related to the more orderly process of cell turnover as a part of normal postnatal aging.…”