Cell receptor screening for human papillomavirus invasion by using a polyoxometalate-peptide assembly as a probe

Bioorthogonal chemistry of polyoxometalates – challenges and prospects

“…Combining anionic POM cores and peptide chains has helped create photosensors for certain biomolecules. 94 Remarkably, the supramolecular design of POM–peptide nanoassemblies can be extended by adding a third component. Zhang et al reported three-component hierarchical core–shell nanoflowers.…”

Polyoxometalate–peptide hybrid materials: from structure–property relationships to applications

“…The first one relies on the quenching of the fluorescence via competitive recognition caused by the disintegration of the hybrid assembly upon addition of the biomolecule of interest. 99 For this, the interaction between the POM and the peptide in the assembly should not be too tight to permit its dissemblance. The POM with the lowest charge, {EuW 10 } (−9), offered the optimal binding capacity in this case.…”

Rational Design and Self-Assembly of Polyoxometalate-Peptide Hybrid Materials

“…With this idea in mind, in 2018 the authors developed a protocol for the detection of a type of cell receptors, glycosaminoglycans (GAGs), that allow the HPV to enter cells. 67 In a competitive recognition of the peptides and GAGs, they studied the fluorescence emission of the ionic POM-peptide hybrids in the presence of different types of GAGs: heparin, chondroitin sulphate and hyaluronic acid. Whenever the peptides showed a high affinity for a specific GAG, the peptide would "leave" the assembly with POMs to bind the GAG, leading to a decrease of the fluorescence of the Eu-POM.…”