Bioorthogonal chemistry of polyoxometalates – challenges and prospects

Abstract

Advances in bioorthogonal polyoxometalate (POM) chemistry will open exciting opportunities for the controlled use of stimuli-responsive POM-based organic–inorganic nanoassemblies in biomedical applications as well as catalysis and electronics.

The effect of ionic versus covalent functionalization of polyoxometalate hybrid materials with coordinating subunits on their stability and interaction with DNA

“…34 Both derivatization with organic moieties via covalent bonds and their encapsulation inside non-toxic organic macromolecules could lead to systems with enhanced biocompatibility, higher stability at physiological pH and lower toxicity. 36–39 However, these results are still scarcely understood, and the need to construct such systems and studies is therefore justified.…”

Using Coordination Chemistry to Control “Click” Reactions: The Selective Formation of Asymmetrically Ligated Polyoxometalates

“…Organic functionalization and postfunctionalization of polyoxometalates (POMs) provides a set of powerful tools for stabilizing them and tailoring their functional characteristics, − greatly enriching the field of inorganic POM science . Bis-trialkoxo (bis- tris ) ligated (in a transoid fashion), fully oxidized Lindqvist-type organic–inorganic hexavanadate (abbreviated as V 6 ) hybrids are readily synthetically available, − chemically stable, and provide a robust platform for combining the stimuli-responsive electronic structure properties of V 6 with almost unlimited possibilities and advances of organic, , organometallic, − supramolecular, − and even biochemical , approaches.…”