Cell Proliferation Response to Sulfhydryl in Mammals

Hammett, Frederick S.; Reimann, Stanley P.

doi:10.1084/jem.50.4.445

Cited by 41 publications

(4 citation statements)

References 2 publications

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“…Several papers assessed the capacity of various SH compounds to enhance wound healing in rats and rabbits. These studies used thiocresol, merthiolate, and thioglycerol . All were modest studies with Hammett and Reimann displaying accelerated healing in 20 of 25 wounds.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

“…These studies used thiocresol, merthiolate, and thioglycerol . All were modest studies with Hammett and Reimann displaying accelerated healing in 20 of 25 wounds. Similar findings were reported with rats and rabbits with Powell et al .…”

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

“…In neither case was a quantitative measure of healing provided. A representative picture was demonstrated by Hammett and Reimann from which an estimation of healing could be made. From the picture, one can discern greater wound healing in the treated rats.…”

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

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Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Calabrese

2013

Wound Repair Regeneration

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This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing and its attempted acceleration from its start in the beginning of the 20th century to approximately 1960. Emphasis is placed on the development of cell culture in the assessment of wound healing and in attempts to validate experimental findings via clinical research. Of particular interest were the observations that wound healing could be accelerated in the 30-50% range with the dose response displaying biphasic characteristics consistent with the hormesis dose-response model. Such findings set the stage for the hormetic dose-response revolution that is occurring within the biological and biomedical sciences, including wound healing, whereby considerable research now supports the capacity for endogenous and exogenous agents to accelerate the process of wound healing and its functional performance.

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Section: Early Product Testing and Applicationsmentioning

confidence: 99%

Section: Early Product Testing and Applicationsmentioning

confidence: 99%

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Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Calabrese

2013

Wound Repair Regeneration

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“…For example, in a case of embryonal carcinoma with lymphoid stroma, without métastases, the excretion of prolan A may be only 2 Observations on the effect of treatment on the excre¬ tion of prolan A in teratoma testis are practically con¬ fined to the effect of irradiation. The 117 patients in this series were treated by means of high voltage roentgen therapy or radium element pack.…”

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confidence: 99%

Pathologic Physiology of Teratoma Testis

Ferguson¹

1933

JAMA

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ment, the bladder is pushed forward and to the right, I feel that the left ureter is put on a stretch, while the right ureter angulates at the point where it traverses the parametrium. Why is it that pyelitis does not occur in every case of ureteral dilatation, in the presence of bacteria? The third determining factor is the lowering of the resistance of the organism. My studies have shown that in pregnant women there occurs a lowering of resistance to B. coli in about nine out of a hundred cases. The same phenomenon occurs in women following labor when there is excessive loss of blood. With the idea of pos¬ sibly preventing the occurrence of pyelitis by stimulating the peristaltic activity of the ureter, I now give pregnant women from the fifth month of pregnancy on calcium and potassium citrate in large doses and twice a week ephedrine orally and have reduced the occurrence of pyelitis to about Y per cent.Dr. E. G. Crabtree, Boston : There was no doubt that the cases to which Dr. Folsom referred were cases of cystitis without involvement of the upper urinary tract. Absence of upper urinary tract infection, while not proved in every case, was demonstrated in some. Residual urine during the course of pregnancy has been mentioned. After several years of following our cases in this regard we do not find residual urine except in rather unusual conditions and when there is a cystocele. Dr. Hofbauer has brought up many interesting questions. I assign a double cause for the dilatation of the ureter and pelvis in pregnancy. This is atony of the ureter and pelvis as a result of endocrine changes due to pregnancy and pressure applied by the uterus at the brim of the pelvis. New Orleans : The trail blazers in the field of postpartum urinary sepsis have been Hofbauer, Crabtree and Prather, and I wish to pay them respectful tribute. It has been the stimulating tenor of their work that has encouraged us to carry on with our study. We shall con¬ tinue our work with pyridium in order to report later whether we feel the same as some do or whether we shall retain our present high regard for this dye antiseptic. Certainly no con¬ vincing evidence has yet been advanced to show that pyridium, when administered in proper dosage and over a sufficient period of time, is not therapeutically effective. Davis attempted to solve this problem by showing that bacteria would grow in the voided urine of normal medical students who had taken various dyes by mouth. Helmholz substitutes rabbits for test tubes. Neither of these studies proves anything of clinical value. Physicians are not called on to treat test tubes or rabbits. Admitting the intricacy of investigations in dye therapy, we do not feel that the final evaluation of pyridium will be settled in the laboratory. Observational Ability.-Diagnostic success at the bedside may be held to depend firstly upon the historical analysis, and secondly upon our personal powers of observation, both of which are subject to the continual leaven of experience. Nothing is so variable as observational abi...

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Sulphur Content of Hair and of Nails in Abnormal States

Brown¹

1933

Arch Derm Syphilol

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Cell Proliferation Response to Sulfhydryl in Mammals

Cited by 41 publications

References 2 publications

Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Historical foundations of wound healing and its potential for acceleration: dose‐response considerations

Pathologic Physiology of Teratoma Testis

Sulphur Content of Hair and of Nails in Abnormal States

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