Cell proliferation: Enhancement by extracts from cell surfaces of polyoma-virus-transformed cells

Beierle, John W.

doi:10.1097/00007890-196902000-00010

Cited by 3 publications

(3 citation statements)

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“…l4 There is evidence that mucopolysaccharides of the cell periphery influence the behavior of cells.15 Acid mucopolysaccharides derived from polyomavirus transformed fibroblasts promote cell proliferation in culture, but do not when derived from normal cells. 16 Beierle and associates found marked enhancement of cell proliferation by the mucinous serum component isolated from a patient with Wilms' tumor." Finally, mucopolysaccharides may also blockade tumor antigens and thus promote tumor growth.…”

Section: Discussionmentioning

confidence: 99%

Poor prognosis for mucin-producing Wilms' tumor

Ater

Gooch

Bybee

et al. 1984

Cancer

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This report describes two cousins with Wilms' tumor and mucin detected in the sera with rapidly fatal courses. A review of the literature reveals five additional reported cases of Wilms' tumor where mucin was observed in the sera. The patients in this report are similar to those previously reported in that all had metastatic disease at diagnosis, and four of five died within one year of diagnosis. Both the extent of disease at diagnosis at the poor response to therapy in these two cases, and those from the literature suggest that evidence of mucin production may indicate poor prognosis in Wilms' tumor. In addition, evidence is reviewed that mucin itself may contribute to a rapid tumor growth and metastases. The genetics of Wilms' tumor and familial nature of these cases is also discussed.

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Section: Discussionmentioning

confidence: 99%

Poor prognosis for mucin-producing Wilms' tumor

Ater

Gooch

Bybee

et al. 1984

Cancer

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“…Introduction of foreign proteins into cell membrane has been proposed as a common feature of cancer cells (16,20,192). The hypothesis of changed properties of bacteria as a result of introduction of FV protein into bacterial membrane would parallel this hypothesis.…”

Section: Model Of the Molecularmentioning

confidence: 99%