Cell‐Penetrable Lysine Dendrimers for Anti‐Cancer Drug Delivery: Synthesis and Preliminary Biological Evaluation

Zhao, Jing; Fu, Xiaoyu; Ren, Wen Xiu; Ma, Lei; Li, Ran; Zhao, Yi; Guo, Li

doi:10.1002/ardp.201300415

Cited by 16 publications

(10 citation statements)

References 36 publications

(37 reference statements)

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“…Moreover, it is widely accepted that nanoparticles can be easily absorbed by cells (Thurn et al 2011;Sokolova et al 2013). For this reason, a variety of nanoparticle systems are currently being explored for cancer therapeutics (Haley and Frenkel 2008), which include dendrimers (Zhao et al 2014), liposome (Allison 2007;Bovis et al 2012), micelles (Lee et al 2003), carbon nanotubes (Huang et al 2010), and polymeric nanoparticles (Kumari et al 2010;Li and Liu 2014). Several nanoparticles based on organic and inorganic chromophores, which show strong absorption in the near-infrared (NIR) tissuetransparency window, such as gold and carbon nanomaterials, have displayed encouraging photothermal therapeutic efficacy in preclinical animal experiments (Yuan et al 2012;Chu et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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Polyaniline nanoparticles (PANI-Nps) have been used in several applications; however, there are few publications related to the use in the photothermal therapy. PANI-Nps have high optical absorbance in the near-infrared region and in this wavelength range, biological systems are relatively transparent. For this reason, these materials can be used to absorb energy and to generate heat that destroys cancer cells selectively. PANI-Nps with average size of ca. 200 nm and neutral zeta potential were synthesized and characterized by DLS, SEM, and zeta potential. The kinetics of incorporation of PANINps into LM2 cell line was monitored using UV-Vis spectrophotometry. The analysis of cell viability after PANI-Nps exposure shows that these nanoparticles are not cytotoxic even at high concentration and show no change in cell morphology and metabolic activity. Furthermore, we found that nanoparticle cell uptake reaches the maximum value c.a. 3 h after incubation. Cells were targeted by Pani-Nps and irradiated, resulting in significant elevation of intracellular ROS and heat production. One of the mechanisms of PANINps-mediated photothermal killing of cancer cells apparently involved oxidative stress resulting in apoptotic cell death.

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Section: Introductionmentioning

confidence: 99%

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

et al. 2015

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“…Moreover, it decreases toxic effects to normal tissues and the pHsensitive bond is fast cleaved in acidic conditions. 43 Based on the use of CPP-dendrimer derived (CPPD) for increasing the internalization of drugs, 44,45 Zhao et al 44 (2014) investigated the cell penetrable lysine dendrimers conjugate with 5-fluororacil (G1-G3). The authors observed some advantages such as stability, low toxicity to normal cells, although moderate activity in tumors was demonstrated.…”

Section: R a F Tmentioning

confidence: 99%

Peptide dendrimers: drug/gene delivery and other approaches

et al. 2017

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Dendrimers are versatile hyperbranched molecules, which have deserved attention especially for their potential in many applications, including biological. Peptide dendrimers comprise interesting classes of dendrimers, and their use has been emphasized as a drug/bioactive compound delivery system, mostly in the antineoplastic area. The bioactive molecules can be covalently linked or entrapped inside the peptide derivative. Self-assembled nanocarriers are a recent trend in the design of potential delivery systems, and pH-sensitive carriers, one of their methods, have been designed to control their systems. In addition, the use of targeting peptides or other specific groups that direct the drug/bioactive compounds to specific organs is an important trend in the search for better drug delivery systems. Recent examples have been given in the literature, showing that gene delivery as another important peptide dendrimer application. It is worth emphasizing that some peptide dendrimers show activity per se, without bioactive compounds. Immune compounds and vaccines are presented herein, as well as uses of other peptide dendrimers are briefly discussed in this review, which encompasses around 10 years of work.

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“…Similarly, Mcguigan et al have disclosed NUC-1031, a gemcitabine phosphoramidate prodrug that has shown significant reduction in viability of tumor cells [187]. Zhao et al demonstrated the efficacy of cell penetrable dendrimer as a potential antitumor drug carrier by 5-FU and lysine dendrimer conjugates [188]. Several nanocarriers like PEGylated lipids for squalenoyl amphiphilic prodrugs of gemcitabine and dideoxycytidine [189] and polymeric micelles for stearoyl-gemcitabine [190] are being developed to improve the efficacy and sustainability of the anticancer properties.…”

Section: Prodrug Approach: Analog / Chemical Conjugation For Cancementioning

confidence: 99%

Novel delivery approaches for cancer therapeutics

Mitra

Agrahari

Mandal

et al. 2015

Journal of Controlled Release

130

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Currently, a majority of cancer treatment strategies are based on the removal of tumor mass mainly by surgery. Chemical and physical treatments such as chemo- and radiotherapies have also made a major contribution in inhibiting rapid growth of malignant cells. Furthermore, these approaches are often combined to enhance therapeutic indices. It is widely known that surgery, chemo- and radiotherapy also inhibit normal cells growth. In addition, these treatment modalities are associated with severe side effects and high toxicity which in turn lead to low quality of life. This review encompasses novel strategies for more effective chemotherapeutic delivery aiming to generate better prognosis. Currently, cancer treatment is a highly dynamic field and significant advances are being made in the development of novel cancer treatment strategies. In contrast to conventional cancer therapeutics, novel approaches such as ligand or receptor based targeting, triggered release, intracellular drug targeting, gene delivery, cancer stem cell therapy, magnetic drug targeting and ultrasound-mediated drug delivery, have added new modalities for cancer treatment. These approaches have led to selective detection of malignant cells leading to their eradication with minimal side effects. Lowering, multi-drug resistance and involving influx transportation in targeted drug delivery to cancer cells can also contribute significantly in the therapeutic interventions in cancer.

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Cell‐Penetrable Lysine Dendrimers for Anti‐Cancer Drug Delivery: Synthesis and Preliminary Biological Evaluation

Cited by 16 publications

References 36 publications

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Polyaniline nanoparticles for near-infrared photothermal destruction of cancer cells

Peptide dendrimers: drug/gene delivery and other approaches

Novel delivery approaches for cancer therapeutics

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