Cell Origin of Collagenase in Normal and Wounded Corneas

“…On the other hand. Brown and Weller [1970a] did not find any collagenase in the corneas of normal rabbits. Nevertheless, when a rabbit's cornea is burned with 0.5% caustic soda, collagenase appears in large quantities at the edges of the ulcer, but its concentration decreases as the distance from the ulcer increases.…”

Section: Collagenase In Human Tissuesmentioning

confidence: 72%

Collagenase and the Collagenase Inhibitors in Torpid Ulcers of the Cornea

François¹,

Cambie²

1972

Ophthalmic Res

View full text Add to dashboard Cite

Rabbit corneas were burned with 0.5% caustic soda. Subsequently, they were treated with a solution of cysteine 0.15m or a suspension of cystine 0.15 m, with excellent results. Clinically, we obtained surprisingly good results by treating torpid ulcers of the cornea with a suspension of cystine 0.15 m. In the case of infected ulcers of the cornea which could not be sterilized, this treatment was without effect.

show abstract

“…Fungi and bacteria are capable of promoting enzymatic degradation of the cornea. This process is aggravated by attracted neutrophils, which degranulate in the corneal stroma and release additional lytic enzymes 25–27 . The diagnosis of keratomycosis is made by the finding of fungal elements during cytologic examination of corneal scrapings or mycologic culture or during histopathologic examination of a keratectomy specimen 2,10,28 .…”

Section: Summary and Retrospective Commentsmentioning

confidence: 99%

Keratitis due toHistoplasmaspp. in a horse

Richter

Hauser

Kaps

et al. 2003

Veterinary Ophthalmology

View full text Add to dashboard Cite

A 5-year-old Holsteiner gelding from Germany was presented 2 months after a whitish discoloration of the left cornea was observed. Cytologic examination revealed intra- and extracellular globular structures, up to 4 micro m in size, consisting of a central spherical deeply basophilic body surrounded by an unstained halo. The structures were morphologically consistent with Histoplasma spp. Infection with Histoplasma organisms is not endemic in Europe. Topical use of fluconazole was successful in eliminating Histoplasma organisms within 10 days of initiation of treatment.

show abstract

Cell Origin of Collagenase in Normal and Wounded Corneas

Cited by 52 publications

References 7 publications

Pathogenesis of Ulcers of the Alkali-Burned Cornea

Pathogenesis of Ulcers of the Alkali-Burned Cornea

Collagenase and the Collagenase Inhibitors in Torpid Ulcers of the Cornea

Keratitis due toHistoplasmaspp. in a horse

Contact Info

Product

Resources

About