Cell migration regulated by RGD nanospacing and enhanced under moderate cell adhesion on biomaterials

Liu, Qiong; Zheng, Shuang; Yang, Kai; He, Junhao; Shen, Yang; Cui, Shuquan; Huang, Jiale; Gu, Yexin; Ding, Jiandong

doi:10.1016/j.biomaterials.2020.120327

Cited by 97 publications

(68 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When comparing the motile shapes that our model produces, they bear similarity to the shapes of different motile cells [59]. Similar to experimental observations [60][61][62], we predict a maximum of the migration speed as function of the adhesion strength (Fig. 9b).…”

Section: Motile Vesicles At Low Protein Densitiessupporting

confidence: 81%

Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces

Sadhu

Penič

Iglič

et al. 2021

Preprint

View full text Add to dashboard Cite

Eukaryotic cells adhere to extracellular matrix during the normal development of the organism, forming static adhesion as well as during cell motility. We study this process by considering a simplified coarse-grained model of a vesicle that has uniform adhesion energy with a flat substrate, mobile curved membrane proteins and active forces. We find that a high concentration of curved proteins alone increases the spreading of the vesicle, by the self-organization of the curved proteins at the high curvature vesicle-substrate contact line, thereby reducing the bending energy penalty at the vesicle rim. This is most significant in the regime of low bare vesicle-substrate adhesion. When these curved proteins induce protrusive forces, representing the actin cytoskeleton, we find efficient spreading, in the form of sheet-like lamellipodia. Finally, the same mechanism of spreading is found to include a minimal set of ingredients needed to give rise to motile phenotypes.

show abstract

Section: Motile Vesicles At Low Protein Densitiessupporting

confidence: 81%

Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces

Sadhu

Penič

Iglič

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…ROP is executed typically in the presence of metal carboxylate with a hydroxyl-containing compound, normally alcohols, H 2 O, or macromolecules with hydroxy end group (denoted as ROH). Poly(ethylene glycol) (PEG) is one of the most common hydroxyl-containing chemicals in assisting synthesis of polyesters, and PEG itself is a hydrophilic polymer which has been widely applied as medical excipient and bio-matrix [ 49 , 50 , 51 ].…”

Section: Synthesis Of Plamentioning

confidence: 99%

Poly(lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties—From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications

et al. 2021

View full text Add to dashboard Cite

Environmental problems, such as global warming and plastic pollution have forced researchers to investigate alternatives for conventional plastics. Poly(lactic acid) (PLA), one of the well-known eco-friendly biodegradables and biobased polyesters, has been studied extensively and is considered to be a promising substitute to petroleum-based polymers. This review gives an inclusive overview of the current research of lactic acid and lactide dimer techniques along with the production of PLA from its monomers. Melt polycondensation as well as ring opening polymerization techniques are discussed, and the effect of various catalysts and polymerization conditions is thoroughly presented. Reaction mechanisms are also reviewed. However, due to the competitive decomposition reactions, in the most cases low or medium molecular weight (MW) of PLA, not exceeding 20,000–50,000 g/mol, are prepared. For this reason, additional procedures such as solid state polycondensation (SSP) and chain extension (CE) reaching MW ranging from 80,000 up to 250,000 g/mol are extensively investigated here. Lastly, numerous practical applications of PLA in various fields of industry, technical challenges and limitations of PLA use as well as its future perspectives are also reported in this review.

show abstract

“…[ 29 ] Poly(ethylene glycol) (PEG) is one of the most common hydroxyl‐containing chemicals to assist synthesis of polyesters, and PEG itself is a hydrophilic polymer and has been widely applied as medical excipients and bio‐matrix. [ 30‐38 ] For example, PEG/polyester amphiphilic block copolymers play an important role in the thermogel family as a versatile injectable matrix in many medical fields such as tissue engineering, controlled drug release, prevention of postoperative adhesion, submucosal cushion for endoscopic submucosal dissection. [ 39‐55 ]…”

Section: Background and Originality Contentmentioning

confidence: 99%

Coordination Insertion Mechanism of Ring‐Opening Polymerization of Lactide Catalyzed by Stannous Octoate^†

et al. 2021

Self Cite

View full text Add to dashboard Cite

Main observation and conclusion Ring‐opening polymerization (ROP) of cyclic esters in the presence of stannous octoate (Sn(Oct)2) is the main way to obtain biodegradable aliphatic polyesters, an important family of biodegradable polymers which have been widely used and still rapidly developed in the fields of biomedical polymers and environment‐friendly materials. The underlying mechanism is thought via a coordination‐insertion way, but the pathway is still open owing to the absence of direct experimental evidence. Herein, we inquire this issue through density functional theory (DFT) calculations. According to our DFT calculations and the following Curtin‐Hammett evaluation, the carbonyl oxygen has a significant advantage over the ester oxygen, and thus the ring is opened mainly through pathway A instead of pathway B. The stannous octoate is identified as a catalyst rather than an initiator. We eventually summarize the main stages during the whole polymerization of lactide.

show abstract

Cell migration regulated by RGD nanospacing and enhanced under moderate cell adhesion on biomaterials

Cited by 97 publications

References 68 publications

Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces

Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces

Poly(lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties—From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications

Coordination Insertion Mechanism of Ring‐Opening Polymerization of Lactide Catalyzed by Stannous Octoate^†

Contact Info

Product

Resources

About

Cell migration regulated by RGD nanospacing and enhanced under moderate cell adhesion on biomaterials

Cited by 97 publications

References 68 publications

Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces

Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces

Poly(lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties—From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications

Coordination Insertion Mechanism of Ring‐Opening Polymerization of Lactide Catalyzed by Stannous Octoate†

Contact Info

Product

Resources

About

Coordination Insertion Mechanism of Ring‐Opening Polymerization of Lactide Catalyzed by Stannous Octoate^†