Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy

Lv, Yanchun; Yao, Xiangyun; Li, Xiao; Ouyang, Yuanming; Fan, Cunyi; Qian, Yun

doi:10.4103/1673-5374.380872

Cited by 4 publications

(2 citation statements)

References 109 publications

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“…Regarding the molecular mechanisms of onset, researchers have explored several metabolic pathways in diabetic peripheral neuropathy, including the polyol pathway, hexosamine biosynthesis pathway, protein kinase C pathway and the excessive production of advanced glycation end-products [ 31–33 ]. ROS damage and mitochondrial dysfunction are likely the ultimate pathways [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Biodegradable microspheres via orally deliver celastrol with ameliorated neuropathic pain in diabetes rats

Zhao,

Chen,

Lin

et al. 2024

Regenerative Biomaterials

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The treatment of peripheral neuropathy resulting from diabetes primarily emphasizes neurotrophic medications. However, a growing body of clinical studies indicates that neuroinflammation plays a significant role in the pathogenesis of neuropathic pain. This has spurred active exploration of treatment strategies leveraging nanomedicine for diseases, aiming for superior therapeutic outcomes. In this context, we have developed biodegradable nanoparticles made of polylactic-co-glycolic acid, loaded with triptolide (pCel), designed to alleviate somatic cell neuropathic pain induced by diabetes. Treatment with pCel notably reduced levels of reactive oxygen species (ROS) and apoptosis in vitro. Furthermore, the progression of streptozotocin (STZ)-induced diabetes, characterized by elevated renal function indices (blood urea nitrogen, creatinine), liver function indices (bilirubin, alkaline phosphatase), and decreased levels of albumin and globulin, was mitigated following pCel administration. Importantly, oral treatment with pCel significantly inhibited mechanical allodynia and the activation of the sciatic glial cells in diabetic rats. These findings indicate that this synthetic, biodegradable nanomedicine exhibits excellent stability, biocompatibility, and catalytic activity, making it a promising and innovative approach for the management of chronic pain conditions associated with diabetic neuropathy.

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Section: Resultsmentioning

confidence: 99%

Biodegradable microspheres via orally deliver celastrol with ameliorated neuropathic pain in diabetes rats

Zhao,

Chen,

Lin

et al. 2024

Regenerative Biomaterials

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“…In the present review, degeneration and regeneration processes are focused on events occurring in healthy as well as in "diseased" microenvironments, using diabetes and an underlying diabetic neuropathy as experimental models [28]. In the presence of hyperglycemia, such as in type 1 diabetes in particular, the level of blood glucose may be important for the efficiency of both the degeneration and regeneration processes [29,30], but the lipid pattern (dyslipidemia) and obesity are also relevant mechanisms for the development of neuropathy and other nerve disorders in type 2 diabetes [31,32].…”

Section: Introductionmentioning

confidence: 99%

The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes

Dahlin

2023

IJMS

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Appropriate animal models, mimicking conditions of both health and disease, are needed to understand not only the biology and the physiology of neurons and other cells under normal conditions but also under stress conditions, like nerve injuries and neuropathy. In such conditions, understanding how genes and different factors are activated through the well-orchestrated programs in neurons and other related cells is crucial. Knowledge about key players associated with nerve regeneration intended for axonal outgrowth, migration of Schwann cells with respect to suitable substrates, invasion of macrophages, appropriate conditioning of extracellular matrix, activation of fibroblasts, formation of endothelial cells and blood vessels, and activation of other players in healthy and diabetic conditions is relevant. Appropriate physical and chemical attractions and repulsions are needed for an optimal and directed regeneration and are investigated in various nerve injury and repair/reconstruction models using healthy and diabetic rat models with relevant blood glucose levels. Understanding dynamic processes constantly occurring in neuropathies, like diabetic neuropathy, with concomitant degeneration and regeneration, requires advanced technology and bioinformatics for an integrated view of the behavior of different cell types based on genomics, transcriptomics, proteomics, and imaging at different visualization levels. Single-cell-transcriptional profile analysis of different cells may reveal any heterogeneity among key players in peripheral nerves in health and disease.

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Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy

Ratan,

Rajput,

Pareek

et al. 2024

Biomedicines

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Diabetic neuropathy (DN) is a neurodegenerative disorder that is primarily characterized by distal sensory loss, reduced mobility, and foot ulcers that may potentially lead to amputation. The multifaceted etiology of DN is linked to a range of inflammatory, vascular, metabolic, and other neurodegenerative factors. Chronic inflammation, endothelial dysfunction, and oxidative stress are the three basic biological changes that contribute to the development of DN. Although our understanding of the intricacies of DN has advanced significantly over the past decade, the distinctive mechanisms underlying the condition are still poorly understood, which may be the reason behind the lack of an effective treatment and cure for DN. The present study delivers a comprehensive understanding and highlights the potential role of the several pathways and molecular mechanisms underlying the etiopathogenesis of DN. Moreover, Schwann cells and satellite glial cells, as integral factors in the pathogenesis of DN, have been enlightened. This work will motivate allied research disciplines to gain a better understanding and analysis of the current state of the biomolecular mechanisms behind the pathogenesis of DN, which will be essential to effectively address every facet of DN, from prevention to treatment.

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Cell metabolism pathways involved in the pathophysiological changes of diabetic peripheral neuropathy

Cited by 4 publications

References 109 publications

Biodegradable microspheres via orally deliver celastrol with ameliorated neuropathic pain in diabetes rats

Biodegradable microspheres via orally deliver celastrol with ameliorated neuropathic pain in diabetes rats

The Dynamics of Nerve Degeneration and Regeneration in a Healthy Milieu and in Diabetes

Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy

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