Cell membrane-coated nanomaterials for cancer therapy

Zeng, Shiying; Tang, Qinglai; Xiao, Minna; Tong, Xinying; Yang, Tao; Yin, Dandan; Lei, Lanjie; Li, Shi-Sheng

doi:10.1016/j.mtbio.2023.100633

Cited by 23 publications

(18 citation statements)

References 262 publications

(313 reference statements)

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“…All things considered, these results show the potential of CMNPs in tumor gene therapy, providing a promising strategy for effective and targeted cancer treatment, especially in metastatic settings. 218…”

Section: Applications Of Cmnpsmentioning

confidence: 99%

Cell membrane-coated biomimetic nanomedicines: productive cancer theranostic tools

Ijaz,

Aslam,

Hasan

et al. 2024

Biomater. Sci.

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Section: Applications Of Cmnpsmentioning

confidence: 99%

Cell membrane-coated biomimetic nanomedicines: productive cancer theranostic tools

Ijaz,

Aslam,

Hasan

et al. 2024

Biomater. Sci.

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“…The bilayer phospholipid membrane structure of cell membranes (CM) can wrap and camouflage the nanozymes and enhance their biocompatibility, whereas the different cell membranes on which they are based can provide them with specific targeting. , Previous studies have shown the presence of certain molecules on the surface of apoptosis cell membranes (ACM) that can attract macrophages and promote their phagocytosis . Ji et al designed an ACM-coated antioxidant nanozyme (AOzyme).…”

Section: Functionalization Modification Of Nanozymesmentioning

confidence: 99%

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Liu

et al. 2023

ACS Appl. Nano Mater.

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Nanomaterials that can mimic the activity of various enzymes have been studied extensively in the biomedical field in recent years. Nanozymes offer better stability and economic value in comparison to natural enzymes. Additionally, nanozymes have characteristics of nanomaterials, such as photothermal properties and designability, and therefore have considerable potential. The cellular microenvironment provides the basis for maintaining normal cell growth and function. Increasing evidence shows that imbalances in the homeostasis of the cellular microenvironment constitute a major factor in the development of many diseases. Nanozymes have received considerable attention in recent years as regulators of the cellular microenvironment. In this Review, research on the use of nanozymes to remodel the disease microenvironment is discussed. First, the definition, classification, and enzyme-like activities of nanozymes are introduced; several major disease microenvironments are summarized including tumor, inflammatory, and trauma microenvironments. The role of nanozymes in disease microenvironments and the main strategies for constructing intelligent and responsive nanozyme systems are discussed. The specific applications of nanozymes in remodeling the diseased microenvironment are highlighted. Finally, the therapeutic strategies of nanozymes to remodel the disease microenvironment are summarized and prospected. Nanozyme disease microenvironment remodeling is expected to become a major therapeutic strategy or an adjunct for the prevention and treatment of related diseases.

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“…8−10 By combining synthetic nanoparticle cores with naturally derived cell membrane layers, they inherit the highly complex functionalities of the source cells. 11 These biomimetic nanoparticles possess numerous favorable advantages, including high biocompatibility, 12 reduced toxicity, 13 and specific targeting ability. 5 Additionally, it is well acknowledged that more than 60% of drug-interacting receptors are located on the cell membrane.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, cell membrane-coated nanoparticles have been extensively investigated for biomedical applications, such as drug delivery, , immunotherapy, − biological neutralization , and phototherapy. − By combining synthetic nanoparticle cores with naturally derived cell membrane layers, they inherit the highly complex functionalities of the source cells . These biomimetic nanoparticles possess numerous favorable advantages, including high biocompatibility, reduced toxicity, and specific targeting ability . Additionally, it is well acknowledged that more than 60% of drug-interacting receptors are located on the cell membrane. , Therefore, cell membrane-coated nanoparticles can effectively leverage ligand–receptor interactions through their unique biomimetic design.…”

Section: Introductionmentioning

confidence: 99%

Genetically Engineered Cell Membrane-Coated Nanoparticles with High-Density Customized Membrane Receptor for High-Performance Drug Lead Discovery

Bu,

Wu,

Zhao

et al. 2023

ACS Appl. Mater. Interfaces

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Cell membrane coating strategies have been increasingly researched due to their unique capabilities of biomimicry and biointerfacing, which can mimic the functionality of the original source cells in vivo but fail to provide customized nanoparticle surfaces with new or enhanced capabilities beyond natural cells. However, the field of drug lead discovery necessitates the acquisition of sufficient surface density of specific target membrane receptors, presenting a heightened demand for this technology. In this study, we developed a novel approach to fabricate high density of fibroblast growth factor receptor 4 (FGFR4) cell membrane-coated nanoparticles through covalent site-specific immobilization between genetically engineered FGFR4 with HaloTag anchor on cell membrane and chloroalkane-functionalized magnetic nanoparticles. This technique enables efficient screening of tyrosine kinase inhibitors from natural products. And the enhanced density of FGFR4 on the surface of nanoparticles were successfully confirmed by Western blot assay and confocal laser scanning microscopy. Further, the customized nanoparticles demonstrated exceptional sensitivity (limit of detection = 0.3 × 10–3 μg mL–1). Overall, the proposed design of a high density of membrane receptors, achieved through covalent site-specific immobilization with a HaloTag anchor, demonstrates a promising strategy for the development of cell membrane surface engineering. This approach highlights the potential of cell membrane coating technology for facilitating the advanced extraction of small molecules for drug discovery.

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Cell membrane-coated nanomaterials for cancer therapy

Cited by 23 publications

References 262 publications

Cell membrane-coated biomimetic nanomedicines: productive cancer theranostic tools

Cell membrane-coated biomimetic nanomedicines: productive cancer theranostic tools

Nanozyme-Based Remodeling of Disease Microenvironments for Disease Prevention and Treatment: A Review

Genetically Engineered Cell Membrane-Coated Nanoparticles with High-Density Customized Membrane Receptor for High-Performance Drug Lead Discovery

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