Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy

Dash, Pratigyan; Piras, Anna Maria; Dash, Mamoni

doi:10.1016/j.jconrel.2020.09.012

Cited by 156 publications

(125 citation statements)

References 127 publications

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“…The membrane proteins are isolated from the desired cell (for targeting) and then coated with a synthetic nanomaterial (PLGA, chitosan, MSNs, liposomes, gold nanocages) by different approaches like sonication and extrusion. 166 Until now, various cells have been taken into consideration due to the unique properties of each cell type. RBCs evade the immune system, decreased uptake by macrophages, 167 WBCs and platelets home to injured and inflammation prone areas, 168 cancer cells for homotypic targeting to the desired cancer cell abiding by the principle of hemophilic adhesion between cell adhesion molecules in the cancer cell membrane.…”

Section: Existing Drug Delivery Systems For Bone Therapeuticsmentioning

confidence: 99%

Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma

Samal

Dash

2021

IJN

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The increasing incidence of bone-related disorders is causing a burden on the clinical scenario. Even though bone is one of the tissues that possess tremendous regenerative potential, certain bone anomalies need therapeutic intervention through appropriate delivery of a drug. Among several nanosystems and biologics that offer the potential to contribute towards bone healing, the exosomes from the class of extracellular vesicles are outstanding. Exosomes are extracellular nanovesicles that, apart from the various advantages, are standing out of the crowd for their ability to conduct cellular communication. The internal cargo of the exosomes is leading to its potential use in therapeutics. Exosomes are being unraveled in terms of the mechanism as well as application in targeting various diseases and tissues. Through this review, we have tried to understand and review all that is already established and the gap areas that still exist in utilizing them as drug delivery vehicles targeting the bone. The review highlights the potential of the exosomes towards their contribution to the drug delivery scenario in the bone microenvironment. A comparison of the pros and cons of exosomes with other prevalent drug delivery systems is also done. A section on the patents that have been generated so far from this field is included.

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Section: Existing Drug Delivery Systems For Bone Therapeuticsmentioning

confidence: 99%

Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma

Samal

Dash

2021

IJN

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“…Cell membrane components are a newly emerging class of biomaterials and delivery systems for therapeutic cargoes 18 , 19 , 20 . Red blood cells (RBCs) have long been studied as delivery systems capable of entrapping various cargoes, such as nucleic acids or chemical drugs 21 , 22 , 23 , but the range of cell types used as drug-delivery systems is rapidly expanding 24 , 25 .…”

Section: Introductionmentioning

confidence: 99%

“…Some published reviews have focused on cell membrane-derived vesicles 18 , 26 , 27 , but they mainly introduced new concepts using a few types of cell membranes. As this field has progressed rapidly, we herein comprehensively review various aspects of cell membrane-derived vesicles, including manufacturing methods and surface modification strategies.…”

Section: Introductionmentioning

confidence: 99%

Cell membrane-derived vesicles for delivery of therapeutic agents

Lee

et al. 2021

Acta Pharmaceutica Sinica B

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Cell membranes have recently emerged as a new source of materials for molecular delivery systems. Cell membranes have been extruded or sonicated to make nanoscale vesicles. Unlike synthetic lipid or polymeric nanoparticles, cell membrane-derived vesicles have a unique multicomponent feature, comprising lipids, proteins, and carbohydrates. Because cell membrane-derived vesicles contain the intrinsic functionalities and signaling networks of their parent cells, they can overcome various obstacles encountered in vivo . Moreover, the different natural combinations of membranes from various cell sources expand the range of cell membrane-derived vesicles, creating an entirely new category of drug-delivery systems. Cell membrane-derived vesicles can carry therapeutic agents within their interior or can coat the surfaces of drug-loaded core nanoparticles. Cell membranes typically come from single cell sources, including red blood cells, platelets, immune cells, stem cells, and cancer cells. However, recent studies have reported hybrid sources from two different types of cells. This review will summarize approaches for manufacturing cell membrane-derived vesicles and treatment applications of various types of cell membrane-derived drug-delivery systems, and discuss challenges and future directions.

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“…On the other hand, cancer cell membrane (CCM), an active targeting motif and effective biomimetic material, has been coated on the nanoparticle surface for anti-tumor drug delivery to enhance therapeutic efficiency and minimize adverse effects [ 8 , 9 ]. Owing to the adhesive proteins, homogenesis receptors and natural membrane structure, CCM-camouflaged nanoparticles possess the following specific properties: (1) homologous targeting [ 10 ]; (2) immune escape capability [ 11 ]; (3) improved colloidal stability; and (4) reduced leakage of anti-tumor agents [ 12 ]. Notably, hyperthermia at 43–45 °C was reported to accelerate the fluidity of CCM, resulting in elevated accumulation of anti-cancer agents [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

et al. 2021

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Background Multi-modal therapy has attracted increasing attention as it provides enhanced effectiveness and potential stimulation of the immune community. However, low accumulation at the tumor sites and quick immune clearance of the anti-tumor agents are still insurmountable challenges. Hypothetically, cancer cell membrane (CCM) can homologously target the tumor whereas multi-modal therapy can complement the disadvantages of singular therapies. Meanwhile, moderate hyperthermia induced by photothermal therapy can boost the cellular uptake of therapeutic agents by cancer cells. Results CCM-cloaked indocyanine green (ICG)-incorporated and abraxane (PTX-BSA)-loaded layered double hydroxide (LDH) nanosheets (LIPC NSs) were fabricated for target efficient photo-chemotherapy of colorectal carcinoma (CRC). The CCM-cloaked LDH delivery system showed efficient homologous targeting and cytotoxicity, which was further enhanced under laser irradiation to synergize CRC apoptosis. On the other hand, CCM-cloaking remarkably reduced the uptake of LDH NSs by HEK 293T cells and macrophages, implying mitigation of the side effects and the immune clearance, respectively. In vivo data further exhibited that LIPC NSs enhanced the drug accumulation in tumor tissues and significantly retarded tumor progression under laser irradiation at very low therapeutic doses (1.2 and 0.6 mg/kg of ICG and PTX-BSA), without observed side effects on other organs. Conclusions This research has demonstrated that targeting delivery efficiency and immune-escaping ability of LIPC NSs are tremendously enhanced by CCM cloaking for efficient tumor accumulation and in situ generated hyperthermia boosts the uptake of LIPC NSs by cancer cells, a potential effective way to improve the multi-modal cancer therapy. Graphical Abstract

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Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy

Cited by 156 publications

References 127 publications

Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma

Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma

Cell membrane-derived vesicles for delivery of therapeutic agents

Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

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