Cell membrane-camouflaged nanoparticles as drug carriers for cancer therapy

Xu, Cheng-Hui; Ye, Peng-Ju; Zhou, Yangchun; He, Dongxiu; Wei, Hua; Yu, Cui‐Yun

doi:10.1016/j.actbio.2020.01.036

Cited by 150 publications

(88 citation statements)

References 104 publications

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“…This approach falls inside the development of biomimetic nanotechnologies based on the "camouflaging" methods. The biomimetic NPs not only retain the physicochemical features of the synthetic vehicles but also inherit the cell membranes' intrinsic functionalities [21,22]. As examples, erythrocytes (red blood cell (RBC) membrane-camouflaged nanocarriers (RBC-MCNs)) are used in studies for tunable paclitaxel (PTX) release kinetics from biocompatible isotactic and atactic polylactide (PLA) polymeric vesicles [23] and 5-fluorouracil (5-FU) delivery from by chitosan-coated poly(lactide-co-glycolic acid) nanoparticles [24].…”

Section: Polymeric Lipid and Hybrid Nanostructuresmentioning

confidence: 99%

Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

Bochicchio¹,

Lamberti

Barba

2021

Pharmaceutics

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Some issues in pharmaceutical therapies such as instability, poor membrane permeability, and bioavailability of drugs can be solved by the design of suitable delivery systems based on the combination of two pillar classes of ingredients: polymers and lipids. At the same time, modern technologies are required to overcome production limitations (low productivity, high energy consumption, expensive setup, long process times) to pass at the industrial level. In this paper, a summary of applications of polymeric and lipid materials combined as nanostructures (hybrid nanocarriers) is reported. Then, recent techniques adopted in the production of hybrid nanoparticles are discussed, highlighting limitations still present that hold back the industrial implementation.

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Section: Polymeric Lipid and Hybrid Nanostructuresmentioning

confidence: 99%

Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

Bochicchio¹,

Lamberti

Barba

2021

Pharmaceutics

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“…Researchers intend to retain the unbelievable sensitivity and specificity in nature. Given the shortages of polymer materials, recently a novel biomimetic nanoplatform exploiting natural cell membrane as the cloaks of nanoparticles has emerged 2,6,21–23 . The membrane camouflaging technology was first proposed in 2011, in which researchers utilized erythrocytes as the source of membrane materials 22 .…”

Section: Introductionmentioning

confidence: 99%

Membrane engineering of cell membrane biomimetic nanoparticles for nanoscale therapeutics

Zhang

Cheng

Jin

et al. 2021

Clinical & Translational Med

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In recent years, cell membrane camouflaging technology has emerged as an important strategy of nanomedicine, and the modification on the membranes is also a promising approach to enhance the properties of the nanoparticles, such as cancer targeting, immune evasion, and phototherapy sensitivity. Indeed, diversified approaches have been exploited to re‐engineer the membranes of nanoparticles in several studies. In this review, first we discuss direct modification strategy of cell membrane camouflaged nanoparticles (CM‐NP) via noncovalent, covalent, and enzyme‐involved methods. Second, we explore how the membranes of CM‐NPs can be re‐engineered at the cellular level using strategies such as genetic engineering and membranes fusion. Due to the innate biological properties and excellent biocompatibility, the functionalized cell membrane‐camouflaged nanoparticles have been widely applied in the fields of drug delivery, imaging, detoxification, detection, and photoactivatable therapy.

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“…Although many of the methods described in the literature lead to effective functionalization of nanomaterials surface, the issues with unspecific interactions may prevent successful utilization in some applications [30][31][32][33]. Due to specific requirements in the utilization of bio-functionalized UCNPs in dot blot assays, we focused to develop protocols allowing to obtain functionalized nanoparticles that lack nonspecific interactions with nitrocellulose and immobilon membranes.…”

Section: Introductionmentioning

confidence: 99%

Novel UV-activated biofunctionalization of up-converting nanocrystals for detection of proteins

et al. 2021

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Lanthanide doped nanocrystals capable to emit higher energy photons under excitation with lower energy radiation are promising for a broad range of applications including biodetection, biosensing, and bioimaging. However, the adaptation of these nanoparticles to the biological environment that requires good water-solubility, stability and ease of further functionalization still remains a challenge. The application of nanoparticles for biodetection or in various assays encountered many difficulties arising mainly from the strong tendency of nanoparticles for aggregation or nonspecific binding. Here we present a new method to obtain soluble and stable in water-based buffers NaYF4:Yb3+Er3+ nanocrystals with modified surface ready for further conjugation with biomolecules. In the presented approach polyvinylpyrrolidone/vinyl alcohol copolymer (PVP/VA) with photo-activatable linker (N-5-Azido-2-nitrobenzoyl group—ANB-NOS) was used for initial coating due to its high non-covalent affinity to nanoparticles surface. Subsequent coating with aminated dextran by ultraviolet light activation of ANB-NOS was carried out. This step has a significant impact on nanocrystals stability in the physiological buffer as well as on protein conjugation. Conjugation of biomolecules was possible by employing another photo-linker—sulfosuccinimidyl 4,4′-azipentanoate (sulfo-SDA). Bacterial Protein G has been selected to create a universal immune-imaging agent due to its ability to bind Fc fragment of most mammalian immunoglobulins. Moreover, the direct attachment of antibodies to nanoparticles was also examined. The activity of biofunctionalized nanocrystals was tested in immunoblot test, that confirmed preserved activity of attached molecules and lack of undesired nonspecific binding or precipitation on the assay membrane. Graphic abstract

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Cell membrane-camouflaged nanoparticles as drug carriers for cancer therapy

Cited by 150 publications

References 104 publications

Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

Polymer–Lipid Pharmaceutical Nanocarriers: Innovations by New Formulations and Production Technologies

Membrane engineering of cell membrane biomimetic nanoparticles for nanoscale therapeutics

Novel UV-activated biofunctionalization of up-converting nanocrystals for detection of proteins

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