Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics

Zhu, Li; Zhong, Yuan; Wu, Shuai; Meng, Yan; Cao, Yu; Mu, Nianlian; Wang, Guixue; Sun, Da; Wu, Wei

doi:10.1016/j.mtbio.2022.100228

Cited by 57 publications

(36 citation statements)

References 153 publications

(140 reference statements)

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“…These imagining techniques include magnetic resonance imaging (MRI), positron emission tomography, computerized tomography, photoacoustic tomography, and fluorescence imaging (which employs fluorescent probes capable of converting near‐infrared light excitation into visible light emission). [ 104,105 ] Among the materials investigated, β‐Na YF 4 :Er 3+ ,Yb 3+ UCNPs have captured attention because of their remarkable optical properties, low toxicity, high photostability, and good light penetration depth. However, the main drawbacks of these tumor imaging techniques arise from the lack of specific in vivo tumor‐targeting and localized delivery of contrast agents to tumors.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Cancer imaging is a noninvasive modality for the early detection of cancer, monitoring of tumor progression and detection of metastasis. [ 104,105 ] Different optical imaging techniques have been investigated for cancer diagnosis. These imagining techniques include magnetic resonance imaging (MRI), positron emission tomography, computerized tomography, photoacoustic tomography, and fluorescence imaging (which employs fluorescent probes capable of converting near‐infrared light excitation into visible light emission).…”

Section: Biomedical Applicationsmentioning

confidence: 99%

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Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

et al. 2022

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Biomimetic approaches utilize natural cell membrane-derived nanovesicles to camouflage nanoparticles to circumvent some limitations of nanoscale materials. This emergent cell membrane-coating technology is inspired by naturally occurring intercellular interactions, to efficiently guide nanostructures to the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, the intrinsic biocompatibility of cell membranes allows the crossing of biological barriers and avoids elimination by the immune system. This results in enhanced blood circulation time and lower toxicity in vivo. Macrophages are the major phagocytic cells of the innate immune system. They are equipped with a complex repertoire of surface receptors, enabling them to respond to biological signals, and to exhibit a natural tropism to inflammatory sites and tumorous tissues. Macrophage cell membranefunctionalized nanosystems are designed to combine the advantages of both macrophages and nanomaterials, improving the ability of those nanosystems to reach target sites. Recent studies have demonstrated the potential of these biomimetic nanosystems for targeted delivery of drugs and imaging agents to tumors, inflammatory, and infected sites. The present review covers the preparation and biomedical applications of macrophage cell membranecoated nanosystems. Challenges and future perspectives in the development of these membrane-coated nanosystems are addressed.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Biomedical Applicationsmentioning

confidence: 99%

Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

et al. 2022

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“…Finally, by analyzing the most recent literary sources, it was possible to list the main challenges that stand in the way of the development of BNM technology: (i) there remains much room for the improvement of BNMs in terms of their stability and biocompatibility since BNMs have been used only in animal studies, but they have not been widely used in clinical practice [ 22 ]; (ii) understanding the energetic contributions that rule interactions at the nano–bio interface (i.e., where NPs meet biological barriers, specifically cell membranes) is very complex due to the high compositional heterogeneity of biomembranes and the intrinsic variability of the biological environment [ 34 ]; (iii) the clinical application of BNMs encounters complex fabrication processes, unsuitable large-scale production, low yields, and difficult preservation [ 24 ]; (iv) the utilization of biosynthesis (e.g., engineered bacteria) requires scaled-up manufacturing, dose determination, and potential biosafety studies [ 23 ]; (v) the processing of biomaterials (e.g., bioprinting) that incorporate living cells is still very challenging, especially considering that the production of mechanically rigid and insoluble substrates usually requires nonbiocompatible processes, such as chemical cross-linking or sintering [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

“…The direct copying of a biological prototype may not be successful, even if it is feasible with modern technology [ 13 ]. Currently, biomimetic materials play an important role in medical science in the development of drug delivery systems and theranostics [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ], tissue engineering [ 27 , 28 , 29 ], and combined solutions to these problems [ 30 ]. Chronologically, the first attempts of delivery-system-mimicking were directed towards the development of “biologically inert” nanoparticles (NPs), demonstrating reduced interaction with immune cells.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Nanomaterials: Diversity, Technology, and Biomedical Applications

Гареев

Grouzdev²,

Koziaeva

et al. 2022

Nanomaterials

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Biomimetic nanomaterials (BNMs) are functional materials containing nanoscale components and having structural and technological similarities to natural (biogenic) prototypes. Despite the fact that biomimetic approaches in materials technology have been used since the second half of the 20th century, BNMs are still at the forefront of materials science. This review considered a general classification of such nanomaterials according to the characteristic features of natural analogues that are reproduced in the preparation of BNMs, including biomimetic structure, biomimetic synthesis, and the inclusion of biogenic components. BNMs containing magnetic, metal, or metal oxide organic and ceramic structural elements (including their various combinations) were considered separately. The BNMs under consideration were analyzed according to the declared areas of application, which included tooth and bone reconstruction, magnetic and infrared hyperthermia, chemo- and immunotherapy, the development of new drugs for targeted therapy, antibacterial and anti-inflammatory therapy, and bioimaging. In conclusion, the authors’ point of view is given about the prospects for the development of this scientific area associated with the use of native, genetically modified, or completely artificial phospholipid membranes, which allow combining the physicochemical and biological properties of biogenic prototypes with high biocompatibility, economic availability, and scalability of fully synthetic nanomaterials.

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“…Cell membrane camouflaged biomimetic nanoparticles as examples of theranostics are recently reviewed in ref [ 138 ]. Also theranostics applied for gastrointestinal cancers are fully described in ref [ 139 ].…”

Section: Advanced Strategies For Crc Drug Deliverymentioning

confidence: 99%

Recent advances in targeted drug delivery systems for resistant colorectal cancer

et al. 2022

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Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to the public health. It is known that multiple drug resistance (MDR) is one of the major obstacles in CRC treatment. Tumor microenvironment plus genomic instability, tumor derived exosomes (TDE), cancer stem cells (CSCs), circulating tumor cells (CTCs), cell-free DNA (cfDNA), as well as cellular signaling pathways are important issues regarding resistance. Since non-targeted therapy causes toxicity, diverse side effects, and undesired efficacy, targeted therapy with contribution of various carriers has been developed to address the mentioned shortcomings. In this paper the underlying causes of MDR and then various targeting strategies including exosomes, liposomes, hydrogels, cell-based carriers and theranostics which are utilized to overcome therapeutic resistance will be described. We also discuss implication of emerging approaches involving single cell approaches and computer-aided drug delivery with high potential for meeting CRC medical needs.

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Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics

Cited by 57 publications

References 153 publications

Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Biomimetic Nanomaterials: Diversity, Technology, and Biomedical Applications

Recent advances in targeted drug delivery systems for resistant colorectal cancer

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