Cell-Mediated Hypersensitivity to Mite Antigens in Atopic Dermatitis

Elliston, W. Leon

doi:10.1001/archderm.1982.01650130030013

Cited by 19 publications

(3 citation statements)

References 13 publications

(1 reference statement)

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“…Among these, particular attention has been given to the appearance of type IV hypersensitivity responses resulting from contact with Dp and Df household mite antigens. The significance of these allergens has been shown in studies carried out in vitro ( 10, 15–17) and in vivo ( 18, 19), as well as by some histopathologic works ( 20–22).…”

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confidence: 99%

Immediate and Delayed Hypersensitivity to Mite Antigens in Atopic Dermatitis

Varela

Selores

Gomes

et al. 1999

Pediatric Dermatology

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Atopic dermatitis (AD) is a common disorder and appears to be on the increase, especially among children. It was thought at first to be a manifestation of immediate hypersensitivity, but it is now known that delayed hypersensitivity also plays an important role. Sensitivity to mite antigens is found in 20% to 60% of patients when immediate hypersensitivity is evaluated by the detection of specific IgE antibodies and prick tests, and in 30% to 50% of patients when delayed hypersensitivity is studied by patch testing. A prospective randomized study was carried out in the pediatric dermatology clinic on a sample of 51 children under 15 years of age. A prevalence of immediate and delayed hypersensitivity to mites, like that described for other populations, was found. It was further found that there was a positive association, not described in the literature, between the younger age groups and delayed hypersensitivity to mite antigens, while the opposite was true for immediate hypersensitivity. We believe that patch tests with airborne allergens, specifically mites, should be part of the protocol for assessing children with AD, particularly in the younger age groups.

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confidence: 99%

Immediate and Delayed Hypersensitivity to Mite Antigens in Atopic Dermatitis

Varela

Selores

Gomes

et al. 1999

Pediatric Dermatology

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“…17,18) The induced dermatitis is accompanied by elevated serum IgE levels, increased expression of Th2 cytokine mRNA, eosinophil accumulation in the lesions and frequent scratching behavior, which are characteristic features of atopic dermatitis. On the other hand, mite antigen has been suggested to play important roles in the onset and/or development of atopic dermatitis [19][20][21] and breakdown of the epidermal barrier system due to inflammation and scratching is an important worsening factor for dermatitis. In the present study therefore, we attempted to establish a severe atopic dermatitis model by repeated topical application of mite antigen coupled with tape-stripping in NC/Nga mice.…”

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confidence: 99%

Establishment of Allergic Dermatitis in NC/Nga Mice as a Model for Severe Atopic Dermatitis

Gao

Nakamura

Fuseda

et al. 2004

Biological & Pharmaceutical Bulletin

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Mite antigen has been suggested to play important roles in the onset and/or development of atopic dermatitis, and mite antigen-induced dermatitis models appear beneficial for the basic study of atopic dermatitis. In the present study therefore, we attempted to establish an allergic dermatitis model in mice using Dermatophagoides farinae crude extract as an antigen. Mite antigen solution at a concentration of 1 or 10 mg/ml was painted 5 times repeatedly at an interval of 7 d onto the ear of NC/Nga or BALB/c mice with or without simultaneous tape-stripping. Apparent biphasic ear swelling was observed after the 4th and 5th antigen applications in both strains of mice treated with 10 mg/ml of antigen solution. Thickening of the epidermis, fibrosis of the dermis, and the accumulation of inflammatory cells were also observed after the 5th application. The inflammatory changes were more evident in NC/Nga mice than in BALB/c mice and potentiated by tape-stripping. The ear swelling was accompanied by increased serum IgE, increased expression of interleukin-4 mRNA and decreased expression of interferon-g g mRNA in cervical lymph nodes and ears. These results indicate that ear swelling caused by repeated mite antigen application with simultaneous tape-stripping has a Th2-dominant background and that the inflammatory responses are expressed more potently in NC/Nga mice than in BALB/c mice. The dermatitis caused by mite antigen in NC/Nga mice appears to be a useful model for the basic study of atopic dermatitis.

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“…Hausstaubmilben, Pollen, Schimmelpilzbestandteile) eine AD auslösen, unterhalten und/oder verschlimmern können. Birken-und Gräserpollen sowie Hausstaubmilbenallergene [12] verursachen bei sensibilisierten Patienten mit AD, nicht jedoch bei Atopikern mit ausschließlich inhalativer Symptomatik (Rhinitis, Asthma) positive Reaktionen im Epikutantest. Vielfach läßt sich bereits anamnestisch eruieren, daß Aeroallergene Auslöser der AD sind.…”

Section: Inhalative Allergene Als Auslöser Der Atopischen Dermatitisunclassified

Th1-Zellen, Th2-Zellen und atopische Dermatitis

Böhm¹,

Bauer²

1997

Der Hautarzt

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The immunological hallmark of atopic dermatitis (AD) is a Th1/Th2 dysbalance. The reaction to high molecular weight environmental allergens (e.g. pollen, house dust mites), production of IgE and activation of eosinophil granulocytes result from Th2 dominance. The Th2-cytokine interleukin-4 (IL-4) is necessary for IgE synthesis. Additionally, IL-4 inhibits the generation of Th1-cells. The marker cytokine of Th1-cells, interferon gamma (IFN gamma), exhibits reciprocal effects. It inhibits IgE synthesis and Th2 expansion, but supports Th1-cell growth. Beside the well known mechanisms of IgE-mediated immediate type reactions, the relevance of IgE for the pathogenesis of AD seems to be likely since the discovery of IgE-receptors upon Langerhans cell surfaces. Langerhans cell-bound IgE may be possibly necessary for the presentation of high molecular weight aero-allergens. Analyses of Th subsets at different intervals after allergen challenge showed, that Th2-cells play an important role in the initial phase of inflammatory reactions whereas in later stages Th1-cells can be detected in greater numbers.

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Cell-Mediated Hypersensitivity to Mite Antigens in Atopic Dermatitis

Cited by 19 publications

References 13 publications

Immediate and Delayed Hypersensitivity to Mite Antigens in Atopic Dermatitis

Immediate and Delayed Hypersensitivity to Mite Antigens in Atopic Dermatitis

Establishment of Allergic Dermatitis in NC/Nga Mice as a Model for Severe Atopic Dermatitis

Th1-Zellen, Th2-Zellen und atopische Dermatitis

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