Cell kinetics in the study and treatment of head and neck cancer

Molinari, Roberto; Costa, Aurora; Silvestrini, Rosella; Mattavelli, Franco; Cantù, Giulio; Chiesa, Fausto; Volterrani, F

doi:10.1007/978-1-4613-3816-1_10

Cited by 10 publications

(10 citation statements)

References 25 publications

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“…The same figures were reported by Molinari et al (1984), who noted a higher complete regression rate in patients whose tumour proliferative activity was reduced by 70% or more after 1OGy of radiotherapy. Another interesting finding was the correlation between LI reduction and long-term response.…”

supporting

confidence: 85%

“…(Fettig et al, 1973;Courdi et al, 1980;Molinari et al, 1984;Klintenberg et al, 1985), and DNA determination before, during, and after radiotherapy (Ganzer, 1974;Lin et al, 1984;Rutgers, 1985). Inherent characteristics of cells form an important basis for differences in radiosensitivity.…”

Section: Resultsmentioning

confidence: 99%

“…Tumour heterogeneity assumes the existence of subpopulations of cells with different geno-and phenotypes resulting in cell clones with characteristic radiosensitivity, and is considered a major problem in the search for clinically reliable cell kinetic criteria (Friedman, 1975). Molinari et al (1984) found that a decrease in thymidine labelling index (LI) by 70% or more after a 5-day course of radiotherapy (10 Gy) resulted in a higher rate of complete regression. This reduction in LI corresponded to an 82% 3-year disease-free survival, whereas all tumours recurred within 19 months in patients in whom no such LI reduction took place.…”

Section: Resultsmentioning

confidence: 99%

“…Cell doublets counted as a G2-phase or a tetraploid peak can, however, be ruled out as the measurements are performed under visual control, which is the strength of static cytofluorometry versus flow cytometry. According to Molinari et al (1984), the GO/Gl-phase is the period of the cell cycle that has the longest duration (from hours to months); this could be an alternative explanation for the lower responsiveness of the diploid tumours. An interesting finding was that of the 8 squamous cell carcinomas that were eradicated by preoperative radiotherapy, 5 were well differentiated (Figures 2, 4, 6) and 3 moderately well differentiated.…”

Section: Resultsmentioning

confidence: 99%

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DNA measurement – An objective predictor of response to irradiation? A review of 24 squamous cell carcinomas of the oral cavity

et al. 1986

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Summary DNA measurements on biopsy material from 24 squamous cell carcinomas of the oral cavity given preoperative radiotherapy indicate that DNA aneuploid tumours respond better to radiotherapy than do diploid and polyploid tumours. The mean S-phase value was higher (16.1%) for 8 tumours that were eradicated by preoperative radiotherapy than for 13 that did not respond (8.1%). These factors correlated better with the response than did histological and clinical (T) classifications.DNA-ploidy and S-phase estimation can complement the histological diagnosis, and may prove valuable when planning treatment.

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supporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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DNA measurement – An objective predictor of response to irradiation? A review of 24 squamous cell carcinomas of the oral cavity

et al. 1986

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“…For many years, the reliability of cell kinetics as a prognostic predictor for several tumor types has been widely investigated (11)(12)(13)(14)(15)(16)(17). Conversely, the potential usefulness of cell kinetics for predicting responses to different treatment modalities has rarely been studied, especially for head and neck cancer (18)(19)(20)(21)(22).…”

mentioning

confidence: 99%

Cell kinetics and response to primary intra–arterial chemotherapy in patients with advanced oral cavity tumors

Molinari

Costa²,

Veneroni³

et al. 1991

J Oral Pathology Medicine

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The relationship was analyzed between cell kinetics, defined as 3H-thymidine labeling index (3H-TdR LI), and clinical responses for 35 previously untreated patients with locally advanced oral cavity squamous cell carcinomas. Patients were treated with three cycles of vincristine and bleomycin (VB) or of VB plus methotrexate (VBM), given by intra-arterial infusion followed by surgery. The objective clinical response rate was higher after VBM treatment than after VB, whereas overall clinical response rates were similar for patients with slowly or rapidly proliferating tumors. The probability of relapse-free survival at 4 yr and overall survival was significantly higher for patients with high 3H-TdR LI tumors given VBM than for those given VB. For patients with slowly proliferating tumors, there were no differences in relapse-free survival and overall survival between the two treatments. These data suggest that patients with rapidly proliferating tumors benefit from primary intensive chemotherapy treatment including methotrexate and that cell kinetics can be used to formulate rational clinical protocols for oral cavity cancers.

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Labeling index in squamous cell carcinoma of the larynx

et al. 1991

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Two cell kinetic parameters, the 3H-thymidine labeling index (TLI) and the mitotic index (MI), were studied in vitro on fragments of squamous cell carcinoma tissue of the larynx. They were evaluated to identify those elements able to characterize the growth of these solid tumors. The values of these parameters were analyzed as a function of the clinical stage and the involvement of the regional lymph nodes. Results showed a statistically significant increase in the TLI from stage ll to T3. No statistically significant differences in the TLI values were observed between the patients with positive and negative lymph nodes. HEAD & NECK 1991;13:344-348 As yet, no reliable histomorphologic or biochemical parameters have been determined which, based on tumor growth and its correlation to clinical data, can be used safely in therapeutic planning to improve prognosis.The proliferative rate of tumors is subject to a marked variability due to intrinsic characteristics, such as cell cycle time, growth fraction, cell loss, and degree of differentiation. Tumor growth is further influenced by the microenvironment and by the immunologic response of the patient. Therefore, the evolution of a malignant neoplasia can show much variability depending on factors linked to the disease, to the patient, and to treatment and its effectiveness in controlling tumor growth.Even with these limitations, evaluation of the number of cells that are duplicating DNA at the time of surgical removal gives a direct indication of the growth capacity of the tumor. Several studies, performed on a large number of patients and with an adequate follow-up, demonstrate that the 3H-thymidine labeling index (TLI) value at the time of surgery is a valuable prognostic instrument for neoplasias of the breast, ovaries, head, and neck. '-6 The aim of the present study was to analyze the correlations between cell kinetic parameters and clinical stage, involvement of regional lymph nodes before treatment, rate of relapse, metastasis, and survival when long-term follow-up data are available. MATERIALS AND METHODSThirty one consecutive patients (27 men, 4 women), between 47 and 72 years of age (median 62 years), were examined in this study. All had tumors of the larynx, localized in the supraglottic region, and classified as squamous cell carcinomas.

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Cell kinetics in the study and treatment of head and neck cancer

Cited by 10 publications

References 25 publications

DNA measurement – An objective predictor of response to irradiation? A review of 24 squamous cell carcinomas of the oral cavity

DNA measurement – An objective predictor of response to irradiation? A review of 24 squamous cell carcinomas of the oral cavity

Cell kinetics and response to primary intra–arterial chemotherapy in patients with advanced oral cavity tumors

Labeling index in squamous cell carcinoma of the larynx

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